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Expression of Mage Genes in Primary and Metastatic Cutaneous Melanoma

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Brasseur, Francis [UCL] Vanwijck, Romain [UCL] Humblet, Yves [UCL] Bourlond, André [UCL] Suciu, Stefan [UCL] Lachapelle, Jean-Marie [UCL] Boon, Thierry [UCL]

Human genes MAGE-1 and MAGE-3 code for antigens that are recognized on melanoma cells by autologous cytolytic T lymphocytes. These antigens may constitute useful targets for specific anti-tumor immunization of cancer patients, since genes MAGE-1 and MAGE-3 are expressed in a number of tumors of different histological types, but are not expressed in normal adult tissues other than testis. This also applies to genes MAGE-2 and MAGE-4, which are closely related to MAGE-1 and MAGE-3. We have analyzed the expression of these 4 MAGE genes in cutaneous melanoma. Sixteen of 100 primary tumors vs. 69 (48%) of 145 metastases from individual patients expressed MAGE-1. Similar differences in the frequency of gene expression between primary and metastatic tumor samples were observed for MAGE-2, MAGE-3, and MAGE-4. MAGE expression in primary tumors was correlated with tumor thickness: there was a significantly increased frequency in the expression of MAGE-1, -2 and -3 in tumors of greater thickness. Benign and dysplastic nevi, as well as in site melanomas, did not express any of the 4 MAGE genes. (C) 1995 Wiley-Liss, Inc.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2004
Language Anglais
Journal information "International Journal of Cancer" - Vol. 63, no. 3, p. 375-380 (2004)
Peer reviewed yes
Publisher Wiley-liss (Hoboken)
issn 0020-7136
e-issn 1097-0215
Publication status Publié
Affiliations UCL - Cliniques universitaires Saint-Luc
UCL - MD/MINT - Département de médecine interne
Links
  1. AJCC (American Joint Committee on Cancer), Manual for staging of cancer, pp. 143–148. J. B. Lippincott, Philadelphia (1992).
  2. Albino Anthony P., Fountain Jane W., Molecular genetics of human malignant melanoma, Cancer Treatment and Research (1993) ISBN:9781461363453 p.201-255, 10.1007/978-1-4615-3080-0_8
  3. and 15 others A comparison of prognostic factors worldwide. In: , , and (eds.), Cutaneous melanoma, pp. 188–199, J. B. Lippincott, Philadelphia (1992).
  4. and , Histopathology of malignant melanoma and its precursor lesions. In: , , and (eds.), Cutaneous melanoma, pp. 234–263, J. B. Lippincott, Philadelphia (1992).
  5. Becker, Int. J. Cancer, 58, 346 (1994)
  6. Brasseur, Int. J. Cancer, 52, 839 (1992)
  7. Breslow, Ann. Sure., 172, 902 (1970)
  8. Celis, Mol. Immunol, 31, 1423 (1994a)
  9. Celis, Proc. nat. Acad. Sci. (Wash.), 91, 2105 (1994b)
  10. Clark, Cancer Res., 29, 705 (1969)
  11. Coulie, J. exp. Med., 180, 35 (1994)
  12. Davis Leonard G., Dibner Mark D., Battey James F., Guanidine Isothiocyanate Preparation of Total RNA, Basic Methods in Molecular Biology (1986) ISBN:9780444010827 p.130-135, 10.1016/b978-0-444-01082-7.50040-0
  13. De Plaen, Immunogenetics, 40, 360 (1994)
  14. Gaugler, J. Exp. Med., 179, 921 (1994)
  15. Inoue, Int. J. Cancer, 64, 76 (1995)
  16. Kwon, Proc. nat. Acad. Sci. (Wash.), 88, 9228 (1991)
  17. Kwon, Proc. nat. Acad. Sci. (Wash.), 84, 7473 (1987)
  18. Patard, Int. J. Cancer, 64, 60 (1995)
  19. Traversari, J. exp. Med., 176, 1453 (1992)
  20. Van der Bruggen, Europ. J. Immunol., 24, 3038 (1994a)
  21. Van der Bruggen, Europ. J. Immunol., 24, 2134 (1994b)
  22. Van der Bruggen, Science, 254, 1643 (1991)
  23. Weber, Cancer Res., 54, 1766 (1994)
  24. Weynants, Int. J. Cancer, 56, 826 (1994)
Bibliographic reference Brasseur, Francis ; Vanwijck, Romain ; Humblet, Yves ; Bourlond, André ; Suciu, Stefan ; et. al. Expression of Mage Genes in Primary and Metastatic Cutaneous Melanoma. In: International Journal of Cancer, Vol. 63, no. 3, p. 375-380 (2004)
Permanent URL http://hdl.handle.net/2078.1/48370