Muscatelli, F.
Walker, AP.
De Plaen, Etienne
[UCL]
Stafford, AN.
Monaco, AP.
A human gene with strong homology to the MAGE gene family located in XqZ7-qter has been isolated by using exon-trapping of cosmids in the Xp21.3 region. We have mapped and sequenced cDNA and genomic clones corresponding to this gene, MAGE-Xp, and shown that the last exon contains the open reading frame and is present in a minimum of five copies in a 30-kb interval, MAGE-Xp, is expressed only in testis and, unlike the Xq27-qter MAGE genes, it is not expressed in any of 12 different tumor tissues tested. However, the gene and predicted protein structure are conserved, suggesting a similar function, MAGE-Xp is located in the 160-kb critical interval defined for the locus involved in sex determination within Xp21 and is 50 kb distal to the DAX-1 gene, which is responsible for X-chromosome-linked adrenal hypoplasia congenita.
| Bibliographic reference |
Muscatelli, F. ; Walker, AP. ; De Plaen, Etienne ; Stafford, AN. ; Monaco, AP.. Isolation and Characterization of a Mage Gene Family in the Xp21.3 Region. In: National Academy of Sciences. Proceedings, Vol. 92, no. 11, p. 4987-4991 (1995) |
| Permanent URL |
http://hdl.handle.net/2078.1/48059 |
