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Interactions Between the Lipophilic Opioid Sufentanil and Clonidine in Rats After Spinal Application

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Meert, TF. De Kock, Marc [UCL]

Background. Alpha(2)-adrenoceptor agonists, such as clonidine. can potentiate the analgesic properties of spinal opioids. In order to further extend this observation to highly lipophilic and potent spinally acting opioids, we tested the interactions between clonidine and sufentanil after both epidural and intrathecal administration in rats. Methods. The rats were equipped with spinal catheters. Antinociceptive testing was performed with the Tail Withdrawal Reaction test. Dose-response functions of sufentanil, clonidine and combinations of clonidine plus sufentanil were determined. Results. These indicated that 1) sufentanil, but not clonidine alone, results in a dose-related antinociception after both the epidural and the intrathecal route of administration; 2) In combination with normally inactive doses of sufentanil, the addition of clonidine results in activity; 3) In a particular dose-range of sufentanil, there is a direct relationship between the doses of sufentanil and clonidine needed to produce antinociception; 4) Even at very high doses of clonidine, a minimal amount of sufentanil is needed to produce antinociception and 5) At the conditions tested here, the contribution of clonidine is minimal at high, intrinsic active doses of sufentanil.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 1995
Language Anglais
Journal information "Acta Anaesthesiologica Scandinavica : an international journal of anaesthesiology and intensive care, pain and emergency medicine" - Vol. 39, no. 4, p. 527-534 (1995)
Peer reviewed yes
Publisher Munksgaard Int Publ Ltd (Copenhagen)
issn 0001-5172
e-issn 1399-6576
Publication status Publié
Affiliations UCL - Cliniques universitaires Saint-Luc
UCL - MD/CHIR - Département de chirurgie
Keywords CLONIDINE ; EPIDURAL ADMINISTRATION ; INTERACTION ANALYSIS ; INTRATHECAL ADMINISTRATION ; SPINAL ACTIVITY, SUFENTANIL
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Bibliographic reference Meert, TF. ; De Kock, Marc. Interactions Between the Lipophilic Opioid Sufentanil and Clonidine in Rats After Spinal Application. In: Acta Anaesthesiologica Scandinavica : an international journal of anaesthesiology and intensive care, pain and emergency medicine, Vol. 39, no. 4, p. 527-534 (1995)
Permanent URL http://hdl.handle.net/2078.1/47961