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Identification of the nuclear transcription factor NF kappa B in rat brain after in vivo ethanol administration

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Ward, Roberta J. [UCL] Zhang, Y. Crichton, Robert [UCL] Piret, B Piette, J De Witte, Philippe [UCL]

NF kappa B, a nuclear transcription factor, was induced in the brain nuclear fraction of naive rats after an acute injection of ethanol, 2 g/kg. In contrast, rats which had been chronically alcoholised showed the constitutively active NF kappa B-like complex only after a further acute dose of ethanol. Hepatic nuclear fractions did not exhibit the specific NF kappa B-like complex during the first 45 min after acute ethanol injection, beyond that which was normally constitutively present, Such activation of NF kappa B-like complex in the brains of the naive rats may play an important role in the cellular protective response.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1996
Language Anglais
Journal information "FEBS Letters" - Vol. 389, no. 2, p. 119-122 (1996)
Peer reviewed yes
Publisher Elsevier Science Bv (Amsterdam)
issn 0014-5793
e-issn 1873-3468
Publication status Publié
Affiliation UCL
Keywords nuclear transcription factor ; NF kappa B ; ethanol
Links
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Bibliographic reference Ward, Roberta J. ; Zhang, Y. ; Crichton, Robert ; Piret, B ; Piette, J ; et. al. Identification of the nuclear transcription factor NF kappa B in rat brain after in vivo ethanol administration. In: FEBS Letters, Vol. 389, no. 2, p. 119-122 (1996)
Permanent URL http://hdl.handle.net/2078.1/47062