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Insect cell bioreactors

Bibliographic reference Agathos, Spiros N.. Insect cell bioreactors. In: Cytotechnology : international journal of cell culture and biotechnology, Vol. 20, no. 1-3, p. 173-189 (1996)
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  1. AgathosSN (1993) The future of cell culture engineering. In: GoosenMFA, DaugulisAJ & FaulknerP (eds) Insect Cell Culture Engineering, pp. 221?240. Marcel Dekker, New York.
  2. AgathosSN (1994) Large scale insect cell production. In: MaramoroschK & McIntoshAH (eds) Insect Cell Biotechnology, pp. 89?103. CRC Press, Roca Raton.
  3. AgathosSN, JeongY-H & VenkatK (1990) Growth kinetics of free and immobilized insect cell cultures. Ann. N.Y. Acad. Sci. 589: 372?398.
  4. Al Rubeai M, Kioukia N & Emery AN (1994) Monitoring of insectbaculovirus culture processes by flow cytometry. Presented at Cell Culture Engineering IV, Engineering Foundation Conferences, San Diego, CA 7?12 March 1994 (Abstract WE3, Cell Culture Engineering IV Program and Abstracts, p. 86).
  5. ArchambaultJ, RobertJ & TomRL (1994) Culture of immobilized insect cells. Bioprocess Eng. 11: 189?197.
  6. BarkhemT, CarlssonB, DanielssonA, NorinderU, FriebergH & ÖhmanL (1992) Production in a 100 liter stirred tank reactor of functional full length human thyroid receptor b1 in Sf-9 insect cells using a recombinant baculovirus. In: VlakJM, SchlaegerE-J & BernardAR (eds) Baculovirus and Recombinant Protein Production Processes, pp. 235?246. Editiones Roche, Basel.
  7. BédartC, JolicoeurM, JardinB, TomR, SerretS & KamenA (1994a) Insect cell density in bioreactor cultures can be estimated from on-line measurements of optical density. Biotechnol. Techniques 8: 605?610.
  8. BédartC, KamenA, TomR & MassieB (1994b) Maximization of recombinant protein yield in the insect cell/baculovirus system by one-time addition of nutrients to high-density batch cultures. Cytotechnology 15: 129?138.
  9. BonariusHPJ, deGooijerCD, TramperJ & SchmidG (1995) Determination of the respiration quotient in mammalian cell culture in bicarbonate buffered media. Biotechnol. Bioeng. 45: 524?535.
  10. CaronAW, ArchambaultJ & MassieB (1990) High-level recombinant protein production in bioreactors using the baculovirus-insect cell expression system. Biotechnol. Bioeng. 36: 1133?1140.
  11. CaronAW, TomRL, KamenAA & MassieB (1994) Baculovirus expression system scaleup by perfusion of high-density Sf-9 cell cultures. Biotechnol. Bioeng. 43: 881?891.
  12. ChalmersJJ (1994) Cells and bubbles in sparged bioreactors. Cytotechnology 15: 311?320.
  13. ChungIS, TaticekRA & ShulerML (1993) Production of human alkaline phosphatase, a secreted glycosylated protein, from a baculovirus expression system and the attachment-dependent cell line Trichoplusia ni BTI-Tn 5B1?4 using a split-flow, airlift bioreactor. Biotechnol. Progress, 9: 675?678.
  14. deGooijerCD, vanLierFLJ, van denEndEJ, VlakJM & TramperJ (1989) A model for baculovirus production with continuous insect cell cultures. Appl. Microbiol. Biotechnol. 30: 497?501.
  15. Depinto W & Familetti PC (1994) Increased expression of recombinant proteins from baculovirus infected cultures using Tn-5B1-4 (High Five) insect cells. In Vitro 30: 722 (Presented at the 1994 Cell and Tissue Culture Congress, Research Triangle Park, NC, 4?7 June 1994).
  16. DeutschmannSM & JägerV (1994) Optimization of the growth conditions of Sf-21 insect cells for high-density perfusion culture in stirred-tank bioreactors. Enzyme Microb. Technol. 16: 1133?1140.
  17. EberhardU & SchügerlK (1987) Investigations of reactors for insect cell culture. Develop. Biol. Standard. 66: 325?330.
  18. FleischakerRJ & SinskeyAJ (1981) Oxygen demand and supply in cell culture. Eur. J. Appl. Microbiol. Biotechnol. 12: 193?197.
  19. GoldblumS, BaeY-K, HinkWF & ChalmersJ (1990) Protective effect of methylcellulose and other polymers on insect cells subjected to laminar shear stress. Biotechnol. Progress 6: 383?390.
  20. GrafH & SchügerlK (1991) Influence of the reciprocating movement on the performance of a membrane aeration system in insect cell cultures. Biotechnol. Techniques 5: 91?94.
  21. GuillameJM, SoriaHM, CouteaultN, HurwitzDR, MultonMC & CrespoA (1992) Insect cell fermentation scale-up for recombinant protein production. In: VlakJM, SchlaegerE-J & BernardAR (eds) Baculovirus and Recombinant Protein Production Processes, pp. 255?261. Editiones Roche, Basel.
  22. HenslerWT & AgathosSN (1994) Evaluation of monitoring approaches and effects of culture conditions on recombinant protein production in baculovirus-infected insect cells. Cytotechnology 15: 177?186.
  23. HenslerW, SinghV & AgathosSN (1994) Sf9 insect cell growth and ?-galactosidase production in serum and serum-free media. Ann. N.Y. Acad. Sci. 745: 149?166.
  24. HinkWF (1982) Production of Autographa californica nuclear polyhedrosis virus in cells from large-scale suspension cultures. In: KurstakE (ed.) Microbial and Viral Pesticides, pp. 493?506. Marcel Dekker, New York.
  25. HinkWF & StraussEM (1976) Growth of Trichoplusia ni (TN-368) cells in suspension culture. In: KurstakE & MaramoroschK (eds) Invertebrate Tissue Culture, pp. 297?300. Academic Press, New York.
  26. HinkWF & StraussEM (1980) Semi-continuous culture of the TN-368 cell line in fermenters with virus production in harvested cells. In: KurstakE, MaramoroschK & DübendorferA (eds) Invertebrate Systems In Vitro, pp 27?33. Elsevier-North Holland Biomedical Press, Amsterdam.
  27. Jäger V (1996) Perfusion culture of insect cells. This volume.
  28. JainD, RamasubramanyanK, GouldS, LennyA, CandeloreM, TotaM, StraderC, AlvesK, CucaG, TungJS HuntG, JunkerB, BucklandBC & SilberklangM (1991) Large-scale recombinant protein production using the insect cell-baculovirus expression vector system: antistasin and ?-adrenergic receptor. In: SpierRE, GriffithsJB & MeignierB (eds.) Production of Biologicals from Animal Cells in Culture, pp. 345?350. Butterworth-Heinemann, Oxford.
  29. JunkerBH, HuntG, BurgessB, AuninsJ & BucklandBC (1994) Modified microbial fermenter performance in animal cell culture and its implications for flexible fermenter design. Bioprocess Eng. 11: 57?63.
  30. KamenAA, TomRL, CaronAW, ChavarieC, MassieB & ArchambaultJ (1991) Culture of insect cells in a helical ribbon impeller bioreactor. Biotechnol. Bioeng. 38: 619?628.
  31. KamenAA & TomR (1994) Mass spectroscopy determination of insect cell respiration rates in culture and production processes. In: SpierRE, GriffithsJB & BertholdW (eds) Animal Cell Technology. Products of Today, Prospects for Tomorrow (12th Meeting of the European Society for Animal Cell Culture Technology) pp. 345?350. Butterworth-Heinemann, Oxford.
  32. Kim K & Familetti PC (1994) Optimal culture conditions for the production of recombinant proteins from baculovirus infected cells. In Vitro 30: 722 (Presented at the 1994 Cell and Tissue Culture Congress, Research Triangle Park, NC, 4?7 June 1994).
  33. KingGA, DaugulisAJ, FaulknerP, BaylyD & GoosenMFA (1988) Growth of baculovirus-infected insect cells in microcapsules to a high cell and virus density. Biotechnol. Lett. 10: 683?688.
  34. KingG, KuzioJ, DaugulisA, FaulknerP, AllenB, WuJ & GoosenMFA (1991) Assessment of virus production and chloramphenicol acetyl transferase expression by insect cells in serum-free and seru-supplemented media using a temperature-sensitive baculovirus. Biotechnol. Bioeng. 38: 1091?1099.
  35. KingGA, DaugulisAJ, FaulknerP & GoosenMFA (1992) Recombinant ?-galactosidase production in serum-free medium in a 14-L airlift bioreactor. Biotechnol. Progr. 8: 567?571.
  36. KioukiaN, NienowAW, EmeryAN & Al-RubeaiM (1995) Physiological and environmental factors affecting the growth of insect cells and infection with baculovirus. J. Biotechnol. 38: 243?251.
  37. KlöppingerM, FertigG, FrauneE & MiltenburgerHG (1990) Multistage production of Autographa california nuclear polyhedrosis virus in insect cell cultures. Cytotechnology 4: 271?278.
  38. KlöppingerM, FertigG, FrauneE & MiltenburgerHG (1991) High cell density perfusion culture of insect cells for production of baculovirus and recombinant protein. In: SpierRE, GriffithsJB & MeignierB (eds) Production of Biologicals from Animal Cells in Culture (10th Meeting of the European Society for Animal Cell Culture Technology) pp. 470?476. Butterworth-Heinemann, Oxford.
  39. KompierR, TramperJ & VlakJM (1988) A continuous process for production of baculovirus using insect-cell cultures. Biotechnol. Lett. 10: 849?854.
  40. KompierR, KislevN, SegalI & KadouriA (1991) Use of a stationary bed reactor and serum-free medium for the production of recombinant protein in insect cells. Enzyme Microb. Technol. 13: 822?827.
  41. KonstantinovKB, PambayunR, MatanguihanR, YoshidaT, PerusichCM & HuW-S (1992) On-line monitoring of hybridoma cell growth using a laser turbidity sensor. Biotechnol. Bioeng. 40: 1337?1342.
  42. KoolM, VondkenJW, vanLierFLJ, TramperJ & VlakJM (1991) Detection and analysis of Autographa californica nuclear polyhedrosis virus mutants with defective interfering properties. Virology 183: 739?746.
  43. LazarteEJ, TossinP-F & NicolauC (1992) Optimization of the production of full-length rCD4 in baculovirus-infected Sf9 cells. Biotechnol. Bioeng. 40: 214?217.
  44. LicariP & BaileyJE (1991) Factors influencing recombinant protein yields in an insect cell ? baculovirus system: multiplicity of infection and intracellular protein degradation. Biotechnol. Bioeng. 37: 238?246.
  45. LicariP, & BaileyJE (1992) Modeling the population dynamics of baculovirus-infected insect cells: optimizing infection stategies for enhanced recombinant protein yields. Biotechnol. Bioeng. 39: 432?441.
  46. LindsayDA & BetenbaughMJ (1992) Quantification of cell culture factors affecting recombinant protein yields in baculovirus-infected insect cells. Biotechnol. Bioeng. 39: 614?618.
  47. MaiorellaB, InlowD, ShaugerA & HaranoD (1988) Large-scale insect cell culture for recombinant protein production. Bio/Technol. 6: 1406?1410.
  48. MiltenburgerHG & DavidP (1980) Mass production of insect cells in suspension. Devel. Biol. Standard. 46: 183?186.
  49. MurhammerDW & GoocheeCF (1988) Scaleup of insect cell cultures: protective effects of Pluronic F-68. Bio/Technol. 6: 1411?1418.
  50. NeutraR, LeviB-Z & ShohamY (1992) Optimization of protein production by the baculovirus expression vector system in shake flasks. Appl. Microbiol. Biotechnol. 37: 74?78.
  51. OgonahO, ShulerML & GranadosRR (1991) Protein production (?-galactosidase) from a baculovirus vector in Spodoptera frugiperda and Trichoplusia ni cells in suspension culture. Biotechnol. Lett. 13: 265?270.
  52. PapoutsakisET (1991) Media additives for protecting freely suspended animal cells against agitation and aeration damage. Trends Biotechnol. 9: 316?324.
  53. ReuvenyS, KempCW, EppsteinL & ShiloachJ (1992) Carbohydrate metabolism in insect cell cultures during cell growth and recombinant protein production. Ann. N.Y. Acad. Sci. 665: 220?237.
  54. ReuvenyS, KimYJ, KempCW & ShiloachJ (1993a) Production of recombinant proteins in high-density insect cell cultures. Biotechnol. Bioeng. 42: 235?239.
  55. ReuvenyS, KimYJ, KempCW & ShiloachJ (1993b) Effect of temperature and oxygen on cell growth and recombinant protein production in insect cell cultures. Appl. Microbiol. Biotechnol. 38: 619?623.
  56. RhodesM, GardinerS & BroadD (1991) Scaleup of animal cell suspension culture. In: HoCS and WangDIC (eds.) Animal Cell Bioreactors, pp. 253?268. Butterworth-Heinemann, Boston.
  57. SchlaegerE-J, FoggettaM, VonachJM & ChristensenK (1993) SF-1, a low cost culture medium for the production of recombinant proteins in baculovirus infected insect cells. Biotechnol. Techniques 7: 183?188.
  58. Schlaeger E-J, Wippler J & Foggetta M (1994) Scale-up of baculovirus expressed recombinant proteins using the High Five insect cell line. Presented at Cell Culture Engineering IV, Engineering Foundation Conferences, San Diego, CA 7?12 March 1994 (Abstract WE2, Cell Culture Engineering IV Program and Abstracts, p. 85).
  59. SchopfB, HowaldtMW & BaileyJE (1990) DNA distribution and respiratory activity of Spodoptera frugiperda populations infected with wild-type and recombinant Autographa california nuclear polyhedrosis virus. J. Biotechnol. 15: 169?186.
  60. ScottRI, BlanchardJH & FergusonCHR (1992) Effects of oxygen on recombinant protein production by suspension cultures of Sf9 insect cells. Enzyme Microb. Technol. 14: 798?804.
  61. ShulerML, ChoT, WickhamT, OgonahO, KoolM, HammerDA, GranadosRR & WoodHA (1990) Bioreactor development for production of viral pesticides or heterologous proteins in insect cell cultures. Ann. N.Y. Acad. Sci. 589: 399?422.
  62. StreettDA & HinkWF (1978) Oxygen consumption of TN 368 cell line infected with AcNPV. J. Invertebr. Pathol. 31: 112?122.
  63. TramperJ, WilliamsJB, JoustraD & VlakJM (1986) Shear sensitivity of insect cells in suspension. Enzyme Microb. Technol. 8: 33?36.
  64. TramperJ, deGooijerKD & VlakJM (1993) Scale-up considerations and bioreactor development for animal cell cultivation. In: GoosenMFA, DaugulisAJ & FaulknerP (eds) Insect Cell Culture Engineering, pp. 139?177. Marcel Dekker, New York.
  65. vanLierFLJ, van denEndEJ, deGooijerCD, VlakJM & TramperJ (1990) Continuous production of baculovirus in a cascade of insect-cell reactors. Appl. Microbiol. Biotechnol. 33: 43?47.
  66. vanLierFLJ, van derMeijsWCJ, GrobbenNA, OlieRA, VlakJM & TramperJ (1992) Continuous ?-galactosidase production with a recombinant baculovirus insect-cell system in bioreactors. J. Biotechnol. 22: 291?298.
  67. VaughnJL (1976) The production of nuclear polyhedrosis virus in large-volume cell cultures. J. Invertebr. Pathol. 28: 233?237.
  68. WangM-Y, KwongS & BentleyWE (1993a) Effects of oxygen/glucose/glutamine feeding in insect cell baculovirus protein expression: a study on epoxide hydrolase production. Biotechnol. Progr. 9: 355?371.
  69. WangM-Y, VakhariaV & BentleyWE (1993b) Expression of epoxide hydrolase in insect cells: a focus on the infected cell. Biotechnol. Bioeng. 42: 240?246.
  70. Wang MY, Valler M, Pulliam TR & Bentley WE (1995) Elicitation of protease activity in Spodoptera frugiperda cell cultures. Presented at the 209th American Chemical Society National Meeting, Anaheim, CA 2?6 April 1995 (Abstract BIOT 120).
  71. WeissSA & VaughnJL (1986) Cell culture methods for large-scale propagation of baculoviruses. In GranadosRR and FredericiBA (eds) The Biology of Baculoviruses, Vol. 2 Practical Applications for Insect Control, pp. 64?87. CRC Press, Boca Raton.
  72. WeissSA, SmithGC, KalterSS & VaughnJL (1981) Improved method for the production of insect cell cultures in large volume. In Vitro 17: 495?502.
  73. WeissSA, OrrT, SmithGC, KalterSS, VaughnJL & DoughertyEM (1982) Quantitative measurement of oxygen consumption in insect cell culture infected with polyhedrosis virus. Biotechnol. Bioeng. 24: 1145?1154.
  74. WeissSA, DeGiovanniA, GodwinG & KohlerJ (1988) Large scale cultivation of insect cells. In: RobertsDW and GranadosRR (eds) Conference on Biotechnology Biological Pesticides and Novel Plant-Pest Resistance for Insect Pest Management, Boyce Thompson Institute for Plant Research, Cornell University, July 18?20, 1988, pp. 22?30 Cornell University Press, Ithaca, NY.
  75. WeissSA, BelisleBW, DeGiovanniA, GodwinG, KohlerJ & SummersMD (1989) Continuous cell lines as substrates for biologicals. Devel. Biol. Standard. 70: 272?279.
  76. WickhamTJ, DavisT, GranadosRR, HammerDA. ShulerML & WoodHA (1991) Baculovirus defective interfering particles are responsible for variations in recombinant protein production as a function of multiplicity of infection. Biotechnol. Lett 13: 483?488.
  77. WickhamTJ, DavisT, GranadosRR, ShulerML & WoodHA (1992) Screening of insect cell lines for the production of recombinant proteins and infectious virus in the baculovirus expression system. Biotechnol. Progress 8: 391?396.
  78. WickhamTJ & NemerowGR (1993) Optimization of growth methods and recombinant protein production in BTI-TN-5B1?4 insect cells using the baculovirus expression vector. Biotechnol. Progress 9: 25?30.
  79. WongTKK, NielsenLK, GreenfieldPF & ReidS (1994) Relationship between oxygen uptake rate and time of infection of Sf9 insect cells infected with a recombinant baculovirus. Cytotechnology 15: 157?167.
  80. WoodHA, JohnstonLB & BurandJP (1982) Inhibition of Autographa californica nuclear polyhedrosis virus replication in high-density Trichoplusia ni cell cultures. Virology 119: 245?254.
  81. WuJ, KingG, DaugulisAJ, FaulknerP, BoneDH & GoosenMFA (1989) Engineering aspects of insect cell suspension culture: a review. Appl. Microbiol. Biotechnol. 32: 249?255.
  82. Wu JY & Goosen MFA (1996) Insect cell immobilization. This volume.
  83. ZhangJ, KalogerakisN, BehieLA & IatrouK (1993) A two-stage bioreactor system for the production of recombinant proteins using a genetically engineered baculovirus/insect cell system. Biotechnol. Bioeng. 42: 357?366.
  84. ZhangJ, KalogerakisN & BehieLA (1994a) Optimization of the physicochemical parameters for the culture of Bombyx mori insect cells used in recombinant protein production. J. Biotechnol. 33: 249?258.
  85. ZhangJ, KalogerakisN, BehieLA & IatrouK (1994b) Optimum infection conditions for recombinant protein production in insect cell (Bm5) suspension culture. Biotechnol. Progr. 10: 636?643.
  86. ZhouW & HuW-S (1994) On-line characterization of a hybridoma cell culture, Biotechnol. Bioeng. 44: 170?177.