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The shared tumor-specific antigen encoded by mouse gene P1A is a target not only for cytolytic T lymphocytes but also for tumor rejection

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Brändle, Daniel [UCL] Bilsborough, Janine [UCL] Rülicke, Thomas [Biological Central Laboratory, University of Zürich, Zürich, Switzerland] Uyttenhove, Catherine [UCL] Boon, Thierry [UCL] Van den Eynde, Benoît [UCL]

A number of human tumor antigens have been characterized recently using cytolytic T lymphocytes (CTL) as screening tools. Some of them are encoded by MAGE-type genes, which are silent in normal tissues except in male germ cells, but are activated in a variety of tumors. These tumor-specific shared antigens appear to be promising targets for cancer immunotherapy. However, the choice of these antigens as targets has been questioned because of the lack of direct evidence that in vivo responses against such antigens can lead to tumor rejection. The antigen encoded by the mouse gene PIA represents the only available animal model system for MAGE-type tumor antigens. We show here that mice immunized by injection of L1210 leukemia cells expressing P1A and B7-1 (L1210.P1A.B7-1) are efficiently protected against a challenge with a lethal dose of mastocytoma P815 tumor cells, which express P1A. Mice immunized with L1210 cells expressing B7-1 but not PIA were not protected. Furthermore, we observed that PIA-transgenic mice, which are tolerant to P1A, were not protected after immunization with L1210.P1A.B7-1. These results demonstrate that the immune response to P1A is the major component of the tumor rejection response observed in normal mice, and support the use of tumor-specific shared antigens as targets for the immunotherapy of human cancer.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1998
Language Anglais
Journal information "European Journal of Immunology" - Vol. 28, no. 12, p. 4010-4019 (1998)
Peer reviewed yes
Publisher Wiley-v C H Verlag Gmbh (Berlin)
issn 0014-2980
e-issn 1521-4141
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
Keywords tumor antigen ; P815 ; cytotoxic T lymphocyte ; P1A ; rejection
Links
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Bibliographic reference Brändle, Daniel ; Bilsborough, Janine ; Rülicke, Thomas ; Uyttenhove, Catherine ; Boon, Thierry ; et. al. The shared tumor-specific antigen encoded by mouse gene P1A is a target not only for cytolytic T lymphocytes but also for tumor rejection. In: European Journal of Immunology, Vol. 28, no. 12, p. 4010-4019 (1998)
Permanent URL http://hdl.handle.net/2078.1/44929