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Quantitation of hepatitis B virus DNA by Abbott's liquid hybridization and by Chiron's branched DNA in interferon treated children

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Goubau, Patrick [UCL] Sokal, Etienne [UCL] Croonen, L

We quantified hepatitis B viral DNA with two methods, the liquid hybridization method developed by Abbott and the branched DNA method of Chiron, in serial samples from 24 children treated with interferon-alpha. and in 70 other selected samples. Correlation of the two methods was good after logarithmic transformation (r(2) = 0.93). Both methods gave comparable evolutions of the the viral load, but the branched DNA method was more sensitive. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1999
Language Anglais
Journal information "Hepatology Research" - Vol. 14, no. 2, p. 171-175 (1999)
Peer reviewed yes
Publisher Elsevier Sci Ireland Ltd (Clare)
issn 1386-6346
e-issn 1872-034X
Publication status Publié
Affiliations UCL - Cliniques universitaires Saint-Luc
UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
UCL - MD/GYPE - Département de gynécologie, d'obstétrique et de pédiatrie
Keywords chronic hepatitis ; pediatrics ; quantitative DNA assay
Links
Bibliographic reference Goubau, Patrick ; Sokal, Etienne ; Croonen, L. Quantitation of hepatitis B virus DNA by Abbott's liquid hybridization and by Chiron's branched DNA in interferon treated children. In: Hepatology Research, Vol. 14, no. 2, p. 171-175 (1999)
Permanent URL http://hdl.handle.net/2078.1/44505