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Electron spin resonance studies of some irradiated pharmaceuticals

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Gibella, M. Crucq, AS. Tilquin, Bernard [UCL] Stocker, P Lesgards, G Raffi, J

Five antibiotics belonging to the cephalosporins and penicillins groups have been irradiated: anhydrous ampicilline acid, amoxicilline acid trihydrate, cefuroxime sodium salt, cloxacilline sodium salt monohydrate and ceftazidime pentahydrate. ESR studies have been carried out, showing the influence of irradiation and storage parameters on the nature and concentration of the free radicals trapped. These results may be used to detect an irradiation treatment on such pharmaceuticals. (C) 2000 Elsevier Science Ltd. All rights reserved.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2000
Language Anglais
Journal information "Radiation Physics and Chemistry" - Vol. 58, no. 1, p. 69-76 (2000)
Peer reviewed yes
Publisher Pergamon-elsevier Science Ltd (Oxford)
issn 0969-806X
e-issn 1879-0895
Publication status Publié
Affiliation UCL - MD/FARM - Ecole de pharmacie
Keywords gamma irradiation ; pharmaceuticals ; cephalosporin ; electron spin resonance
Links
Bibliographic reference Gibella, M. ; Crucq, AS. ; Tilquin, Bernard ; Stocker, P ; Lesgards, G ; et. al. Electron spin resonance studies of some irradiated pharmaceuticals. In: Radiation Physics and Chemistry, Vol. 58, no. 1, p. 69-76 (2000)
Permanent URL http://hdl.handle.net/2078.1/43582