Cavalier, JF
Burton, M
De Tollenaere, C
Dussart, F
Marchand, Chantal
[UCL]
Rees, Jean-François
[UCL]
Marchand-Brynaert, Jacqueline
[UCL]
The coupling of arylboronic acids with 2,6-diamino-3,5-dibromo-1,4-pyrazine (6) gave 2,6-diamino-3,5-diaryl-1,4-pyrazines (7). The reaction of 7 with methyl glyoxal in aqueous EtOH-HCl led to the N,N'-disubstituted products 8, instead of the expected bicyclic imidazolopyrazinones 1. The 2,6-bis[1-(ethoxycarbonyl)ethylamino]-3,5-diaryl-1,4-pyrazines 8 are powerful inhibitors of the AAPH-induced linoleate peroxidation.
| Bibliographic reference |
Cavalier, JF ; Burton, M ; De Tollenaere, C ; Dussart, F ; Marchand, Chantal ; et. al. 2,6-diamino-3,5-diaryl-1,4-pyrazine derivatives as novel antioxidants. In: Synthesis : journal of synthetic organic chemistry, , no. 5, p. 768-772 (2001) |
| Permanent URL |
http://hdl.handle.net/2078.1/42778 |
