Dupont, L.
De Tullio, P
Tinant, Bernard
[UCL]
Pirotte, B.
The crystal structure of the title compound, C11H16N4O2S .H2O, a pancreatic B-cell selective K-ATP channel opener, reveals that that the N-alkylsulfonylguanidine moiety of the drug containing the two guanidine NH groups in the same spatial orientation (in parallel) is closely related to the N-alkylcyanoguanidine moiety of pinacidil in the solid state. The results confirm that the title drug may be considered as a hybrid compound between pinacidil and diazoxide. The crystal packing involves four hydrogen bonds which link the drug and water molecules.
Bibliographic reference |
Dupont, L. ; De Tullio, P ; Tinant, Bernard ; Pirotte, B.. (R/S)-3-(3-Methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide monohydrate. In: Acta Crystallographica Section E-structure Reports Online, Vol. 57, p. O1050-O1051 (2001) |
Permanent URL |
http://hdl.handle.net/2078.1/42451 |