User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Health related quality of life in prostate carcinoma patients - A systematic review of randomized controlled trials

Primary tabs

Efficace, Fabio Bottomley, Andrew van Andel, George

BACKGROUND. Health related quality of life (HRQOL) is increasingly reported as an important endpoint in cancer clinical trials. However, evidence suggests that HRQOL reporting is often inadequate. Given this, the authors undertook a systematic review to evaluate HRQOL assessment methodology and reported outcomes of randomized controlled clinical trials (RCTs) with prostate carcinoma patients. METHODS. A comprehensive search of the literature from 1980 to 2001, mainly on the following databases, was undertaken: MedLine, Cancerlit, and the Cochrane Controlled Trials Register. Studies were identified according to a predefined coding scheme, including HRQOL measure, cultural validity, compliance data reported and the clinical significance of the results, RESULTS. Twenty-five RCTs were identified, involving 8015 patients primarily with metastatic cancer. Bicalutamide was the medical treatment against which most treatment comparisons were made. Limitations identified included the fact that only 44% of the studies gave a rationale for selecting a specific HRQOL measure, 64% of the studies failed to report information about the administration of the HRQOL measure, and 56% failed to report compliance at baseline. The measure most often used was the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Care 30 (EORTC QLQ-C30), although some studies used non-validated HRQOL tools. CONCLUSIONS. The current study revealed a lack of a uniform approach to HRQOL assessment and several methodologic limitations. It is possible that such methodologic limitations have influenced trial findings for HRQOL outcomes.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2003
Language Anglais
Journal information "Cancer" - Vol. 97, no. 2, p. 377-388 (2003)
Peer reviewed yes
Publisher John Wiley & Sons Inc (Hoboken)
issn 0008-543X
e-issn 1097-0142
Publication status Publié
Affiliation UCL - Autre
Keywords prostate carcinoma ; quality of life ; randomized controlled trials ; systematic review
Links
  1. Kiebert, Eur Urol., 31, 56 (1997)
  2. Moinpour, Semin Oncol., 21, 48 (1994)
  3. Aaronson, J Natl Cancer Inst., 85, 365 (1993)
  4. Feld, Support Care Cancer., 3, 23 (1995)
  5. Kong, Ann Pharmacother., 31, 830 (1997)
  6. Velikova, Eur J Cancer., 35, 1571 (1999)
  7. Schumacher, Stat Med., 10, 1915 (1991)
  8. Sanders, BMJ., 317, 1191 (1998)
  9. Juni, BMJ., 323, 42 (2001)
  10. Landis, CA Cancer J Clin., 48, 6 (1998)
  11. Yarbro, Oncol Nurs Forum., 25, 685 (1998)
  12. Sommers, Pharmacoeconomics., 16, 127 (1999)
  13. Schellhammer, Urology., 49, 27 (1997)
  14. Slevin, Br J Cancer., 57, 109 (1998)
  15. Titzer, Proc Am Soc Clin Oncol., 20, 1532 (2001)
  16. Sprangers, J Clin Epidemiol., 45, 743 (1992)
  17. Quality of life. Assessment, analysis and interpretation. Chichester, UK: John Wiley & Sons, 2000.
  18. Stephens, Qual Life Res., 6, 225 (1997)
  19. Wilson, Qual Life Res., 9, 1041 (2000)
  20. Moher, JAMA., 285, 1992 (2001)
  21. Staquet, Qual Life Res., 5, 496 (1996)
  22. Chassany Olivier, Sagnier Pierre, Marquis Patrick, Fullerton Steve, Aaronson Neil, , Patient-Reported Outcomes: The Example of Health-Related Quality of Life—A European Guidance Document for the Improved Integration of Health-Related Quality of Life Assessment in the Drug Regulatory Process, 10.1177/009286150203600127
  23. Bottomley, Lancet Oncol., 3, 145 (2002)
  24. Efficace, Eur J Cancer., 38, 1824 (2002)
  25. Porter A.T., McEwan A.J.B., Powe J.E., Reid R., McGowan D.G., Lukka H., Sathyanarayana J.R., Yakemchuk V.N., Thomas G.M., Erlich L.E., Crook J., Gulenchyn K.Y., Hong K.E., Wesolowski C., Yardley J., Results of a randomized phase-III trial to evaluate the efficacy of strontium-89 adjuvant to local field external beam irradiation in the management of endocrine resistant metastatic prostate cancer, 10.1016/0360-3016(93)90309-j
  26. Chodak, Urology., 46, 849 (1995)
  27. Schellhammer, Urology., 45, 745 (1995)
  28. Tannock, J Clin Oncol., 14, 1756 (1996)
  29. Moinpour, J Natl Cancer Inst., 90, 1537 (1998)
  30. Kantoff, J Clin Oncol., 17, 2506 (1999)
  31. Duncan, Eur J Cancer., 36, 759 (2000)
  32. Small, J Clin Oncol., 18, 1440 (2000)
  33. Dawson, Cancer., 88, 825 (2000)
  34. Thrasher, Mol Urol., 4, 259 (2000)
  35. Kaisary, Eur Urol., 28, 215 (1995)
  36. Iversen, Scand J Urol Nephrol., 30, 93 (1996)
  37. da Silva, Eur J Cancer., 32, 72 (1996)
  38. Pummer, Eur Urol., 32, 81 (1997)
  39. Boccardo, J Clin Oncol., 17, 2027 (1999)
  40. Fossa, Eur Urol., 37, 541 (2000)
  41. Johansson, Scand J Urol Nephrol., 35, 288 (2001)
  42. Fransson, Cancer., 92, 3111 (2001)
  43. Fossa, J Clin Oncol., 19, 62 (2001)
  44. Tyrrell, Eur Urol., 33, 447 (1998)
  45. Debruyne, Urology., 52, 72 (1998)
  46. Iversen, Urology., 51, 389 (1998)
  47. Akakura, Urology., 54, 313 (1999)
  48. Homma, Int J Urol., 6, 229 (1999)
  49. Kuriyama, Jpn J Clin Oncol., 31, 18 (2001)
  50. Design and analysis of quality of life studies in clinical trials. New York: Chapman & Hall/CRC, 2002.
  51. Cleary, Qual Life Res., 4, 207 (1995)
  52. Osoba, J Clin Oncol., 17, 1654 (1999)
  53. HUTH EDWARD J., Irresponsible Authorship and Wasteful Publication, 10.7326/0003-4819-104-2-257
  54. Huston, Lancet., 347, 1024 (1996)
  55. Tramer M. R, Reynolds D J. M, Moore R A., McQuay H. J, Impact of covert duplicate publication on meta-analysis: a case study, 10.1136/bmj.315.7109.635
  56. Pummer, Semin Oncol., 18, 26 (1991)
  57. Soloway, Eur Urol., 29, 105 (1996)
  58. Denis, Urology., 42, 119 (1993)
  59. Eisenberger, N Engl J Med., 339, 1036 (1998)
  60. Porter, Semin Oncol., 20, 38 (1993)
  61. Bales, Urology., 47, 38 (1996)
  62. Tyrrell, Eur Urol., 26, 15 (1994)
  63. Schellhammer, Cancer., 78, 2164 (1996)
  64. Schellhammer, Urology., 47, 54 (1996)
  65. Rosendahl, Prostate., 38, 100 (1999)
  66. Bloomfield, J Clin Oncol., 16, 2272 (1998)
  67. Pickles, Int J Radiat Oncol Biol Phys., 43, 47 (1999)
  68. de Reijke, J Urol., 162, 1658 (1999)
Bibliographic reference Efficace, Fabio ; Bottomley, Andrew ; van Andel, George. Health related quality of life in prostate carcinoma patients - A systematic review of randomized controlled trials. In: Cancer, Vol. 97, no. 2, p. 377-388 (2003)
Permanent URL http://hdl.handle.net/2078.1/41286