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Deep brain stimulation for intractable chronic cluster headache: proposals for patient selection

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Leone, M May, A Franzini, A Broggi, G Dodick, D Bussone, G

Cluster headache is the most severe of the primary headaches. Positron emission tomography and functional MRI studies have shown that the ipsilateral posterior hypothalamus is activated during cluster headache attacks and is structurally asymmetric in these patients. These changes are highly specific for the condition and suggest that the cluster headache generator may be located in that brain area; they further suggest that electrical stimulation of that region might produce clinical improvement in chronic cluster headache sufferers refractory to medical therapy. In five patients with severe intractable chronic cluster headache, hypothalamic electrical stimulation produced complete and long-term pain relief with no relevant side-effects. We therefore consider it essential to propose criteria for selecting chronic cluster headache patients for hypothalamic deep brain stimulation before this procedure is undertaken at other academic medical centres.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2004
Language Anglais
Journal information "Cephalalgia : an international journal of headache" - Vol. 24, no. 11, p. 934-937 (2004)
Peer reviewed yes
Publisher Blackwell Publishing Ltd (Oxford)
issn 0333-1024
e-issn 1468-2982
Affiliation UCL
Keywords cluster headache ; deep brain stimulation ; therapy ; surgery ; hypothalamus
Links
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Bibliographic reference Leone, M ; May, A ; Franzini, A ; Broggi, G ; Dodick, D ; et. al. Deep brain stimulation for intractable chronic cluster headache: proposals for patient selection. In: Cephalalgia : an international journal of headache, Vol. 24, no. 11, p. 934-937 (2004)
Permanent URL http://hdl.handle.net/2078.1/39948