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Liver development update: new embryo models, cell lineage control, and morphogenesis

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Lemaigre, Frédéric [UCL] Zaret, KS

The three phases of liver development that are the focus of this review are: the specification of hepatoblasts within the endoderm, the lineage split of hepatoblasts into hepatocytes and biliary cells, and the interaction of these cells with different mesodermal cell derivatives during liver morphogenesis. Advances in these areas include new genes and experimental models for studying liver development, the role of HNF6 and HNF1beta transcription factors and notch signaling in the hepatocyte-biliary cell lineage decision, the identification of genomic targets for HNF4, and HNF4's role in controlling hepatic epithelial structure and the sinusoidal organization of the liver.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2004
Language Anglais
Journal information "Current Opinion in Genetics & Development" - Vol. 14, no. 5, p. 582-90 (2004)
Peer reviewed yes
Publisher Current Biology Ltd (London)
issn 0959-437X
e-issn 1879-0380
Publication status Publié
Affiliation UCL - MD/BICL - Département de biochimie et de biologie cellulaire
MESH Subject Morphogenesis ; Models, Biological ; Liver - blood supply - embryology - metabolism ; Humans ; Gene Expression Regulation, Developmental ; Endoderm - metabolism ; Cell Lineage ; Animals
Links
Bibliographic reference Lemaigre, Frédéric ; Zaret, KS. Liver development update: new embryo models, cell lineage control, and morphogenesis. In: Current Opinion in Genetics & Development, Vol. 14, no. 5, p. 582-90 (2004)
Permanent URL http://hdl.handle.net/2078.1/39942