User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

1-aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors

Primary tabs

Beadle, CD Boot, J Camp, NP Dezutter, N Findlay, J Walter, MW

A novel series of 1-aryl-3,4-dihydro-1H-quinolin-2-ones have been discovered as potent and selective norepinephrine reuptake inhibitors. Efficient synthetic routes have been developed which allow for the multi-gram preparation of both final targets and advanced intermediates for SAR expansion. (c) 2005 Elsevier Ltd. All rights reserved.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2005
Language Anglais
Journal information "Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology" - Vol. 15, no. 20, p. 4432-4437 (2005)
Peer reviewed yes
Publisher Pergamon-elsevier Science Ltd (Oxford)
issn 0960-894X
e-issn 1464-3405
Publication status Publié
Affiliation UCL
Keywords monoamine reuptake inhibitors ; selective norepinephrine reuptake inhibitor ; SAR ; norepinephrine ; quinolin-2-one ; pharmacophore
Links
Bibliographic reference Beadle, CD ; Boot, J ; Camp, NP ; Dezutter, N ; Findlay, J ; et. al. 1-aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors. In: Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology, Vol. 15, no. 20, p. 4432-4437 (2005)
Permanent URL http://hdl.handle.net/2078.1/39125