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Identification of the new allele B*3556 and extension of the sequences of B*4420 and B*4427

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Voorter, C. E. M. Latinne, Dominique [UCL] Gervais, T. Mulkers, E. M. T. van den Berg-Loonen, E. M.

A new B*35 allele, B*3556, was identified in a Caucasian individual. Direct sequencing of exons 2 and 3 revealed that B*3556 was identical to B*3503, except for a nucleotide substitution from G to A at position 302, which causes a change from AGC to AAC at codon 101. This results in an amino acid change from Ser to Asn at position 77 of the mature protein. Two B*44 alleles, B*4420 and B*4427, were detected in a liver recipient and in an unrelated bone marrow donor, respectively, and their sequences were confirmed. The sequences of exons 1,4 and 5 were also elucidated; for B*4420, these exons proved to be identical to those of B*440201. The sequence of exon 5 of B*4427 showed three mismatches with that of B*440201, implicating that it probably arose from B*440201 by allele conversion with an allele of the B*15, 45, 46, 49 or 50 allele group. Elucidation of the sequence of introns 3 and 4 indicated that the breakpoint for allele conversion has to be located in intron 3 or exon 4.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2006
Language Anglais
Journal information "Tissue Antigens : immune response genetics" - Vol. 68, no. 3, p. 253-256 (2006)
Peer reviewed yes
Publisher Blackwell Publishing (Oxford)
issn 0001-2815
e-issn 1399-0039
Publication status Publié
Affiliations UCL - Cliniques universitaires Saint-Luc
UCL
Keywords B*4420 ; B*4427 ; HLA-B*3556 ; new allele ; sequence-based typing
Links
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Bibliographic reference Voorter, C. E. M. ; Latinne, Dominique ; Gervais, T. ; Mulkers, E. M. T. ; van den Berg-Loonen, E. M.. Identification of the new allele B*3556 and extension of the sequences of B*4420 and B*4427. In: Tissue Antigens : immune response genetics, Vol. 68, no. 3, p. 253-256 (2006)
Permanent URL http://hdl.handle.net/2078.1/38270