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A simplified approach to N- and N,N '-linked 1,2,4-triazoles by transamination

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Naik, Anil Damadar [UCL] Marchand-Brynaert, Jacqueline [UCL] Garcia, Yann [UCL]

A facile one-step procedure for the preparation of 4,4'-bis-1,2,4-triazole is reported. Direct transamination of N,N-dimethylformamide azine dihydrochloride by heating with 4-amino-1,2,4-triazole in refluxing benzene readily yields the target molecule in short duration of time with significant yield (73%). This catalyst-free method was extended to synthesise a series of 4-substituted 1,2,4-triazoles of potential interest in coordination chemistry.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2008
Language Anglais
Journal information "Synthesis : journal of synthetic organic chemistry" - no. 1, p. 149-154 (2008)
Peer reviewed yes
Publisher Georg Thieme Verlag Kg (Stuttgart)
issn 0039-7881
Publication status Publié
Affiliation UCL - SC/CHIM - Département de chimie
Keywords amines
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Bibliographic reference Naik, Anil Damadar ; Marchand-Brynaert, Jacqueline ; Garcia, Yann. A simplified approach to N- and N,N '-linked 1,2,4-triazoles by transamination. In: Synthesis : journal of synthetic organic chemistry, no. 1, p. 149-154 (2008)
Permanent URL http://hdl.handle.net/2078.1/36850