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Substitution of pseudokinase domain residue Val-617 by large non-polar amino acids causes activation of JAK2

Bibliographic reference Dusa, Alexandra ; Staerk, Judith ; Elliott, Joanne ; Pecquet, Christian ; Poirel, Hélène ; et. al. Substitution of pseudokinase domain residue Val-617 by large non-polar amino acids causes activation of JAK2. In: Journal of Biological Chemistry, Vol. 283, no. 19, p. 12941-8 (2008)
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  1. Ihle James N., Kerr Ian M., Jaks and Stats in signaling by the cytokine receptor superfamily, 10.1016/s0168-9525(00)89000-9
  2. Levine Ross L., Wadleigh Martha, Cools Jan, Ebert Benjamin L., Wernig Gerlinde, Huntly Brian J.P., Boggon Titus J., Wlodarska Iwona, Clark Jennifer J., Moore Sandra, Adelsperger Jennifer, Koo Sumin, Lee Jeffrey C., Gabriel Stacey, Mercher Thomas, D’Andrea Alan, Fröhling Stefan, Döhner Konstanze, Marynen Peter, Vandenberghe Peter, Mesa Ruben A., Tefferi Ayalew, Griffin James D., Eck Michael J., Sellers William R., Meyerson Matthew, Golub Todd R., Lee Stephanie J., Gilliland D. Gary, Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis, 10.1016/j.ccr.2005.03.023
  3. BAXTER E, SCOTT L, CAMPBELL P, EAST C, FOUROUCLAS N, SWANTON S, VASSILIOU G, BENCH A, BOYD E, CURTIN N, Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders, 10.1016/s0140-6736(05)74230-6
  4. Kralovics Robert, Passamonti Francesco, Buser Andreas S., Teo Soon-Siong, Tiedt Ralph, Passweg Jakob R., Tichelli Andre, Cazzola Mario, Skoda Radek C., A Gain-of-Function Mutation ofJAK2in Myeloproliferative Disorders, 10.1056/nejmoa051113
  5. Zhao Runxiang, Xing Shu, Li Zhe, Fu Xueqi, Li Qingshan, Krantz Sanford B., Zhao Zhizhuang Joe, Identification of an Acquired JAK2 Mutation in Polycythemia Vera, 10.1074/jbc.c500138200
  6. Saharinen Pipsa, Silvennoinen Olli, The Pseudokinase Domain Is Required for Suppression of Basal Activity of Jak2 and Jak3 Tyrosine Kinases and for Cytokine-inducible Activation of Signal Transduction, 10.1074/jbc.m205156200
  7. Lindauer Klaus, Loerting Thomas, Liedl Klaus R., Kroemer Romano T., Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation, 10.1093/protein/14.1.27
  8. Staerk Judith, Kallin Anders, Demoulin Jean-Baptiste, Vainchenker William, Constantinescu Stefan N., JAK1 and Tyk2 Activation by the Homologous Polycythemia Vera JAK2 V617F Mutation : CROSS-TALK WITH IGF1 RECEPTOR, 10.1074/jbc.c500358200
  9. Yoshimura Akihiko, Nishinakamura Hitomi, Matsumura Yumiko, Hanada Toshikatsu, 10.1186/ar1741
  10. Hookham M. B., Elliott J., Suessmuth Y., Staerk J., Ward A. C., Vainchenker W., Percy M. J., McMullin M. F., Constantinescu S. N., Johnston J. A., The myeloproliferative disorder associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3, 10.1182/blood-2006-08-039735
  11. Müller Mathias, Briscoe James, Laxton Carl, Guschin Dmitry, Ziemiecki Andrew, Silvennoinen Olli, Harpur Ailsa G., Barbieri Giovanna, Witthuhn Bruce A., Schindler Chris, Pellegrini Sandra, Wilks Andrew F., Ihle James N., Stark George R., Kerr lan M., The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction, 10.1038/366129a0
  12. Seubert Nadine, Royer Yohan, Staerk Judith, Kubatzky Katharina F, Moucadel Virginie, Krishnakumar Shyam, Smith Steven O, Constantinescu Stefan N, Active and Inactive Orientations of the Transmembrane and Cytosolic Domains of the Erythropoietin Receptor Dimer, 10.1016/s1097-2765(03)00389-7
  13. Oncogene, 7, 1347 (1992)
  14. Dumoutier L., Van Roost E., Colau D., Renauld J.-C., Human interleukin-10-related T cell-derived inducible factor: Molecular cloning and functional characterization as an hepatocyte-stimulating factor, 10.1073/pnas.170291697
  15. Zapata Juan M., Takahashi Ryosuke, Salvesen Guy S., Reed John C., Granzyme Release and Caspase Activation in Activated Human T-Lymphocytes, 10.1074/jbc.273.12.6916
  16. Tannahill G. M., Elliott J., Barry A. C., Hibbert L., Cacalano N. A., Johnston J. A., SOCS2 Can Enhance Interleukin-2 (IL-2) and IL-3 Signaling by Accelerating SOCS3 Degradation, 10.1128/mcb.25.20.9115-9126.2005
  17. Sotiropoulos A., Differential activation of Stat3 and Stat5 by distinct regions of the growth hormone receptor, 10.1210/me.10.8.998
  18. Eur. Cytokine Netw., 10, 549 (1999)
  19. Lacout C., JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis, 10.1182/blood-2006-02-002030
  20. Wernig G., Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model, 10.1182/blood-2005-12-4824
  21. Lu Xiaohui, Huang Lily Jun-Shen, Lodish Harvey F., Dimerization by a Cytokine Receptor Is Necessary for Constitutive Activation of JAK2V617F, 10.1074/jbc.m707125200
  22. Scott Linda M., Tong Wei, Levine Ross L., Scott Mike A., Beer Philip A., Stratton Michael R., Futreal P. Andrew, Erber Wendy N., McMullin Mary Frances, Harrison Claire N., Warren Alan J., Gilliland D. Gary, Lodish Harvey F., Green Anthony R., JAK2Exon 12 Mutations in Polycythemia Vera and Idiopathic Erythrocytosis, 10.1056/nejmoa065202
  23. Huang Lily Jun-shen, Constantinescu Stefan N., Lodish Harvey F., The N-Terminal Domain of Janus Kinase 2 Is Required for Golgi Processing and Cell Surface Expression of Erythropoietin Receptor, 10.1016/s1097-2765(01)00401-4
  24. Haan Serge, Ferguson Paul, Sommer Ulrike, Hiremath Meena, McVicar Daniel W., Heinrich Peter C., Johnston James A., Cacalano Nicholas A., Tyrosine Phosphorylation Disrupts Elongin Interaction and Accelerates SOCS3 Degradation, 10.1074/jbc.m303170200
  25. J. Leukocyte Biol., 75, 743 (2004)
  26. Am. J. Pathol., 12, 545 (1936)
  27. Radtke Simone, Hermanns Heike M., Haan Claude, Schmitz-Van de Leur Hildegard, Gascan Hugues, Heinrich Peter C., Behrmann Iris, Novel Role of Janus Kinase 1 in the Regulation of Oncostatin M Receptor Surface Expression, 10.1074/jbc.m100822200
  28. Royer Yohan, Staerk Judith, Costuleanu Marcel, Courtoy Pierre J., Constantinescu Stefan N., Janus Kinases Affect Thrombopoietin Receptor Cell Surface Localization and Stability, 10.1074/jbc.m501376200
  29. Radtke Simone, Haan Serge, Jörissen Angela, Hermanns Heike M., Diefenbach Sandra, Smyczek Tanya, Schmitz-VandeLeur Hildegard, Heinrich Peter C., Behrmann Iris, Haan Claude, The Jak1 SH2 Domain Does Not Fulfill a Classical SH2 Function in Jak/STAT Signaling but Plays a Structural Role for Receptor Interaction and Up-regulation of Receptor Surface Expression, 10.1074/jbc.m500822200
  30. Feng J, Witthuhn B A, Matsuda T, Kohlhuber F, Kerr I M, Ihle J N, Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop., 10.1128/mcb.17.5.2497
  31. Wilks A F, Harpur A G, Kurban R R, Ralph S J, Zürcher G, Ziemiecki A, Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase., 10.1128/mcb.11.4.2057
  32. James Chloé, Ugo Valérie, Le Couédic Jean-Pierre, Staerk Judith, Delhommeau François, Lacout Catherine, Garçon Loïc, Raslova Hana, Berger Roland, Bennaceur-Griscelli Annelise, Villeval Jean Luc, Constantinescu Stefan N., Casadevall Nicole, Vainchenker William, A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera, 10.1038/nature03546