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Ligand-independent Homomeric and Heteromeric Complexes between Interleukin-2 or-9 Receptor Subunits and the gamma Chain

Bibliographic reference Malka, Yaniv ; Knoops, Laurent ; Hornakova, Tekla ; Royer, Yohan ; Renauld, Jean-Christophe ; et. al. Ligand-independent Homomeric and Heteromeric Complexes between Interleukin-2 or-9 Receptor Subunits and the gamma Chain. In: Journal of Biological Chemistry, Vol. 283, no. 48, p. 33569-77 (2008)
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  1. Cytokines Cell. Mol. Ther., 4, 243 (1998)
  2. Leonard Warren J., Depper Joel M., Uchiyama Takashi, Smith Kendall A., Waldmann Thomas A., Greene Warner C., A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor, 10.1038/300267a0
  3. Sharon M, Klausner R., Cullen B., Chizzonite R, Leonard W., Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions, 10.1126/science.3095922
  4. Teshigawara K., Interleukin 2 high-affinity receptor expression requires two distinct binding proteins, 10.1084/jem.165.1.223
  5. Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, Munakata H, Nakamura M, Sugamura K, Cloning of the gamma chain of the human IL-2 receptor, 10.1126/science.1631559
  6. Wang X., Structure of the Quaternary Complex of Interleukin-2 with Its  ,  , and  c Receptors, 10.1126/science.1117893
  7. Stauber D. J., Debler E. W., Horton P. A., Smith K. A., Wilson I. A., Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor, 10.1073/pnas.0511161103
  8. Wang H. M., The interleukin 2 receptor. Functional consequences of its bimolecular structure, 10.1084/jem.166.4.1055
  9. Nelson Brad H., Lord James D., Greenberg Philip D., Cytoplasmic domains of the interleukin-2 receptor β and γ chains mediate the signal for T-cell proliferation, 10.1038/369333a0
  10. Nakamura Yoshlaki, Russell Sarah M., Mess Sarah A., Friedmann Michael, Erdos Michael, Francois Christine, Jacques Yannick, Adelstein Stephen, Leonard Warren J., Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signalling, 10.1038/369330a0
  11. Kimura Yutaka, Takeshita Toshikazu, Kondo Motonari, Ishii Naoto, Nakamura Masataka, Van Snick Jacques, Sugamura Kazuo, Sharing of the IL-2 receptor γ chain with the functional IL-9 receptor complex, 10.1093/intimm/7.1.115
  12. LEONARD WARREN J., SHORES ELIZABETH W., LOVE PAUL E., Role of the Common Cytokine Receptor gamma Chain in Cytokine Signaling and Lymphoid Development, 10.1111/j.1600-065x.1995.tb00095.x
  13. Moriggl Richard, Sexl Veronika, Piekorz Roland, Topham David, Ihle James N, Stat5 Activation Is Uniquely Associated with Cytokine Signaling in Peripheral T Cells, 10.1016/s1074-7613(00)80097-7
  14. Nelson Brad H., Willerford Dennis M., Biology of the Interleukin-2 Receptor, Advances in Immunology Volume 70 (1998) ISBN:9780120224708 p.1-81, 10.1016/s0065-2776(08)60386-7
  15. Hofmann S. R., Lam A. Q., Frank S., Zhou Y.-J., Ramos H. L., Kanno Y., Agnello D., Youle R. J., O'Shea J. J., Jak3-Independent Trafficking of the Common   Chain Receptor Subunit: Chaperone Function of Jaks Revisited, 10.1128/mcb.24.11.5039-5049.2004
  16. Damjanovich S., Bene L., Matko J., Alileche A., Goldman C. K., Sharrow S., Waldmann T. A., Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: A fluorescence resonance energy transfer study, 10.1073/pnas.94.24.13134
  17. Constantinescu Stefan N., Keren Tzvia, Russ William P., Ubarretxena-Belandia Iban, Malka Yaniv, Kubatzky Katharina F., Engelman Donald M., Lodish Harvey F., Henis Yoav I., The Erythropoietin Receptor Transmembrane Domain Mediates Complex Formation with Viral Anemic and Polycythemic gp55 Proteins, 10.1074/jbc.m302974200
  18. Lachmanovich E., Shvartsman D. E., Malka Y., Botvin C., Henis Y. I., Weiss A. M., Co-localization analysis of complex formation among membrane proteins by computerized fluorescence microscopy: application to immunofluorescence co-patching studies, 10.1046/j.1365-2818.2003.01239.x
  19. Flex Elisabetta, Petrangeli Valentina, Stella Lorenzo, Chiaretti Sabina, Hornakova Tekla, Knoops Laurent, Ariola Cristina, Fodale Valentina, Clappier Emmanuelle, Paoloni Francesca, Martinelli Simone, Fragale Alessandra, Sanchez Massimo, Tavolaro Simona, Messina Monica, Cazzaniga Giovanni, Camera Andrea, Pizzolo Giovanni, Tornesello Assunta, Vignetti Marco, Battistini Angela, Cavé Hélène, Gelb Bruce D., Renauld Jean-Christophe, Biondi Andrea, Constantinescu Stefan N., Foà Robin, Tartaglia Marco, Somatically acquiredJAK1mutations in adult acute lymphoblastic leukemia, 10.1084/jem.20072182
  20. Walters Denise K., Mercher Thomas, Gu Ting-Lei, O'Hare Thomas, Tyner Jeffrey W., Loriaux Marc, Goss Valerie L., Lee Kimberly A., Eide Christopher A., Wong Matthew J., Stoffregen Eric P., McGreevey Laura, Nardone Julie, Moore Sandra A., Crispino John, Boggon Titus J., Heinrich Michael C., Deininger Michael W., Polakiewicz Roberto D., Gilliland D. Gary, Druker Brian J., Activating alleles of JAK3 in acute megakaryoblastic leukemia, 10.1016/j.ccr.2006.06.002
  21. Pear W. S., Nolan G. P., Scott M. L., Baltimore D., Production of high-titer helper-free retroviruses by transient transfection., 10.1073/pnas.90.18.8392
  22. J. Biol. Chem., 276, 26356 (2001)
  23. Schorle Hubert, Holtschke Thomas, Hünig Thomas, Schimpl Anneliese, Horak Ivan, Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting, 10.1038/352621a0
  24. Constantinescu S. N., Keren T., Socolovsky M., Nam H.-s., Henis Y. I., Lodish H. F., Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain, 10.1073/pnas.081069198
  25. Seubert Nadine, Royer Yohan, Staerk Judith, Kubatzky Katharina F, Moucadel Virginie, Krishnakumar Shyam, Smith Steven O, Constantinescu Stefan N, Active and Inactive Orientations of the Transmembrane and Cytosolic Domains of the Erythropoietin Receptor Dimer, 10.1016/s1097-2765(03)00389-7
  26. Liu Xuedong, Constantinescu Stefan N., Sun Yin, Bogan Jonathan S., Hirsch David, Weinberg Robert A., Lodish Harvey F., Generation of Mammalian Cells Stably Expressing Multiple Genes at Predetermined Levels, 10.1006/abio.2000.4478
  27. Constantinescu S. N., Activation of the erythropoietin receptor by the gp55-P viral envelope protein is determined by a single amino acid in its transmembrane domain, 10.1093/emboj/18.12.3334
  28. Royer Yohan, Staerk Judith, Costuleanu Marcel, Courtoy Pierre J., Constantinescu Stefan N., Janus Kinases Affect Thrombopoietin Receptor Cell Surface Localization and Stability, 10.1074/jbc.m501376200
  29. Blood, 94, 365 (1999)
  30. Henis Y. I., The types II and III transforming growth factor-beta receptors form homo-oligomers, 10.1083/jcb.126.1.139
  31. Gilboa L., Nohe A., Geissendorfer T., Sebald W., Henis Y. I., Knaus P., Bone Morphogenetic Protein Receptor Complexes on the Surface of Live Cells: A New Oligomerization Mode for Serine/Threonine Kinase Receptors, 10.1091/mbc.11.3.1023
  32. Renauld J, Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40, 10.1016/1043-4666(90)90037-t
  33. Gerland Katia, Bataillé-Simoneau Nelly, Baslé Michel, Fourcin Maryvonne, Gascan Hugues, Mercier Louis, Activation of the Jak/Stat signal transduction pathway in GH-treated rat osteoblast-like cells in culture, 10.1016/s0303-7207(00)00314-2
  34. Peelman Frank, Iserentant Hannes, De Smet Anne-Sophie, Vandekerckhove Joël, Zabeau Lennart, Tavernier Jan, Mapping of Binding Site III in the Leptin Receptor and Modeling of a Hexameric Leptin·Leptin Receptor Complex, 10.1074/jbc.m512622200
  35. Willerford Dennis M., Chen Jianzhu, Ferry Judith A., Davidson Laurie, Ma Averil, Alt Frederick W., Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment, 10.1016/1074-7613(95)90180-9
  36. Gilboa Lilach, Wells Rebecca G., Lodish Harvey F., Henis Yoav I., Oligomeric Structure of Type I and Type II Transforming Growth Factor β Receptors: Homodimers Form in the ER and Persist at the Plasma Membrane, 10.1083/jcb.140.4.767
  37. Palacios Ronald, Steinmetz Michael, IL3-dependent mouse clones that express B-220 surface antigen, contain ig genes in germ-line configuration, and generate B lymphocytes in vivo, 10.1016/s0092-8674(85)80053-2
  38. Watowich Stephanie S., Wu Hong, Socolovsky Merav, Klingmuller Ursula, Constantinescu Stefan N., Lodish Harvey F., CYTOKINE RECEPTOR SIGNAL TRANSDUCTION AND THE CONTROL OF HEMATOPOIETIC CELL DEVELOPMENT, 10.1146/annurev.cellbio.12.1.91
  39. Darnell J., Kerr I., Stark G., Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins, 10.1126/science.8197455
  40. Ihle James N, The Stat family in cytokine signaling, 10.1016/s0955-0674(00)00199-x
  41. Brown Richard J, Adams Julian J, Pelekanos Rebecca A, Wan Yu, McKinstry William J, Palethorpe Kathryn, Seeber Ruth M, Monks Thea A, Eidne Karin A, Parker Michael W, Waters Michael J, Model for growth hormone receptor activation based on subunit rotation within a receptor dimer, 10.1038/nsmb977
  42. Remy I., Wilson I. A., Michnick S. W., Erythropoietin Receptor Activation by a Ligand-Induced Conformation Change, 10.1126/science.283.5404.990
  43. Schlessinger Joseph, Cell Signaling by Receptor Tyrosine Kinases, 10.1016/s0092-8674(00)00114-8
  44. Livnah O., Stura E. A., Middleton S. A., Johnson D. L., Jolliffe L. K., Wilson I. A., Crystallographic Evidence for Preformed Dimers of Erythropoietin Receptor Before Ligand Activation, 10.1126/science.283.5404.987
  45. Lu Xiaohui, Huang Lily Jun-Shen, Lodish Harvey F., Dimerization by a Cytokine Receptor Is Necessary for Constitutive Activation of JAK2V617F, 10.1074/jbc.m707125200
  46. Suzuki H, Kundig T., Furlonger C, Wakeham A, Timms E, Matsuyama T, Schmits R, Simard J., Ohashi P., Griesser H, et al., Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta, 10.1126/science.7770771
  47. Kubatzky Katharina F., Ruan Weiming, Gurezka Rolf, Cohen Jacob, Ketteler Robin, Watowich Stephanie S., Neumann Drorit, Langosch Dieter, Klingmüller Ursula, Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor, 10.1016/s0960-9822(01)00018-5
  48. James Chloé, Ugo Valérie, Le Couédic Jean-Pierre, Staerk Judith, Delhommeau François, Lacout Catherine, Garçon Loïc, Raslova Hana, Berger Roland, Bennaceur-Griscelli Annelise, Villeval Jean Luc, Constantinescu Stefan N., Casadevall Nicole, Vainchenker William, A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera, 10.1038/nature03546
  49. BAXTER E, SCOTT L, CAMPBELL P, EAST C, FOUROUCLAS N, SWANTON S, VASSILIOU G, BENCH A, BOYD E, CURTIN N, Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders, 10.1016/s0140-6736(05)74230-6
  50. Levine Ross L., Wadleigh Martha, Cools Jan, Ebert Benjamin L., Wernig Gerlinde, Huntly Brian J.P., Boggon Titus J., Wlodarska Iwona, Clark Jennifer J., Moore Sandra, Adelsperger Jennifer, Koo Sumin, Lee Jeffrey C., Gabriel Stacey, Mercher Thomas, D’Andrea Alan, Fröhling Stefan, Döhner Konstanze, Marynen Peter, Vandenberghe Peter, Mesa Ruben A., Tefferi Ayalew, Griffin James D., Eck Michael J., Sellers William R., Meyerson Matthew, Golub Todd R., Lee Stephanie J., Gilliland D. Gary, Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis, 10.1016/j.ccr.2005.03.023
  51. Kralovics Robert, Passamonti Francesco, Buser Andreas S., Teo Soon-Siong, Tiedt Ralph, Passweg Jakob R., Tichelli Andre, Cazzola Mario, Skoda Radek C., A Gain-of-Function Mutation ofJAK2in Myeloproliferative Disorders, 10.1056/nejmoa051113
  52. Scott Linda M., Tong Wei, Levine Ross L., Scott Mike A., Beer Philip A., Stratton Michael R., Futreal P. Andrew, Erber Wendy N., McMullin Mary Frances, Harrison Claire N., Warren Alan J., Gilliland D. Gary, Lodish Harvey F., Green Anthony R., JAK2Exon 12 Mutations in Polycythemia Vera and Idiopathic Erythrocytosis, 10.1056/nejmoa065202
  53. Staerk Judith, Kallin Anders, Demoulin Jean-Baptiste, Vainchenker William, Constantinescu Stefan N., JAK1 and Tyk2 Activation by the Homologous Polycythemia Vera JAK2 V617F Mutation : CROSS-TALK WITH IGF1 RECEPTOR, 10.1074/jbc.c500358200
  54. Disanto James P., Certain Stéphanie, Wilson Anne, MacDonald H. Robson, Avner Phillip, Fischer Alain, de Saint Basile Geneviève, The murine interleukin-2 receptor γ chain gene: Organization, chromosomal localization and expression in the adult thymus, 10.1002/eji.1830241214
  55. Moriggl Richard, Topham David J, Teglund Stephan, Sexl Veronika, McKay Catriona, Wang Demin, Hoffmeyer Angelika, van Deursen Jan, Sangster Mark Y, Bunting Kevin D, Grosveld Gerard C, Ihle James N, Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells, 10.1016/s1074-7613(00)80025-4
  56. Knoops Laurent, Renauld Jean-Christophe, IL-9 and its Receptor: From Signal Transduction to Tumorigenesis, 10.1080/08977190410001720879
  57. Steenwinckel V., Louahed J., Orabona C., Huaux F., Warnier G., McKenzie A., Lison D., Levitt R., Renauld J.-C., IL-13 Mediates In Vivo IL-9 Activities on Lung Epithelial Cells but Not on Hematopoietic Cells, 10.4049/jimmunol.178.5.3244