User menu

IL-9 induces differentiation of T(H)17 cells and enhances function of FoxP3(+) natural regulatory T cells

Bibliographic reference Elyaman, Wassim ; Bradshaw, Elizabeth M. ; Uyttenhove, Catherine ; Dardalhon, Valerie ; Awasthi, Amit ; et. al. IL-9 induces differentiation of T(H)17 cells and enhances function of FoxP3(+) natural regulatory T cells. In: National Academy of Sciences. Proceedings, Vol. 106, no. 31, p. 12885-12890 (2009)
Permanent URL
  1. Ivanov Ivaylo I., McKenzie Brent S., Zhou Liang, Tadokoro Carlos E., Lepelley Alice, Lafaille Juan J., Cua Daniel J., Littman Dan R., The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells, 10.1016/j.cell.2006.07.035
  2. Bettelli Estelle, Oukka Mohamed, Kuchroo Vijay K, TH-17 cells in the circle of immunity and autoimmunity, 10.1038/ni0407-345
  3. Fontenot Jason D., Gavin Marc A., Rudensky Alexander Y., Foxp3 programs the development and function of CD4+CD25+ regulatory T cells, 10.1038/ni904
  4. Hori S., Control of Regulatory T Cell Development by the Transcription Factor Foxp3, 10.1126/science.1079490
  5. Chen WanJun, Jin Wenwen, Hardegen Neil, Lei Ke-jian, Li Li, Marinos Nancy, McGrady George, Wahl Sharon M., Conversion of Peripheral CD4+CD25−Naive T Cells to CD4+CD25+Regulatory T Cells by TGF-β Induction of Transcription FactorFoxp3, 10.1084/jem.20030152
  6. 24, 179 (2006)
  7. Bettelli Estelle, Carrier Yijun, Gao Wenda, Korn Thomas, Strom Terry B., Oukka Mohamed, Weiner Howard L., Kuchroo Vijay K., Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells, 10.1038/nature04753
  8. Korn Thomas, Bettelli Estelle, Gao Wenda, Awasthi Amit, Jäger Anneli, Strom Terry B., Oukka Mohamed, Kuchroo Vijay K., IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells, 10.1038/nature05970
  9. Knoops Laurent, Renauld Jean-Christophe, IL-9 and its Receptor: From Signal Transduction to Tumorigenesis, 10.1080/08977190410001720879
  10. Lu Li-Fan, Lind Evan F., Gondek David C., Bennett Kathy A., Gleeson Michael W., Pino-Lagos Karina, Scott Zachary A., Coyle Anthony J., Reed Jennifer L., Van Snick Jacques, Strom Terry B., Zheng Xin Xiao, Noelle Randolph J., Mast cells are essential intermediaries in regulatory T-cell tolerance, 10.1038/nature05010
  11. Veldhoen Marc, Uyttenhove Catherine, van Snick Jacques, Helmby Helena, Westendorf Astrid, Buer Jan, Martin Bruno, Wilhelm Christoph, Stockinger Brigitta, Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset, 10.1038/ni.1659
  12. Demoulin, Cancer Research, 60, 3971 (2000)
  13. Demoulin J B, Uyttenhove C, Van Roost E, DeLestré B, Donckers D, Van Snick J, Renauld J C, A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9., 10.1128/mcb.16.9.4710
  14. Dardalhon Valérie, Awasthi Amit, Kwon Hyoung, Galileos George, Gao Wenda, Sobel Raymond A, Mitsdoerffer Meike, Strom Terry B, Elyaman Wassim, Ho I-Cheng, Khoury Samia, Oukka Mohamed, Kuchroo Vijay K, IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells, 10.1038/ni.1677
  15. Yang Xuexian O., Panopoulos Athanasia D., Nurieva Roza, Chang Seon Hee, Wang Demin, Watowich Stephanie S., Dong Chen, STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells, 10.1074/jbc.c600321200
  16. Demoulin Jean-Baptiste, Van Roost Emiel, Stevens Monique, Groner Bernd, Renauld Jean-Christophe, Distinct Roles for STAT1, STAT3, and STAT5 in Differentiation Gene Induction and Apoptosis Inhibition by Interleukin-9, 10.1074/jbc.274.36.25855
  17. Langrish Claire L., Chen Yi, Blumenschein Wendy M., Mattson Jeanine, Basham Beth, Sedgwick Jonathan D., McClanahan Terrill, Kastelein Robert A., Cua Daniel J., IL-23 drives a pathogenic T cell population that induces autoimmune inflammation, 10.1084/jem.20041257
  18. Yao Z., Kanno Y., Kerenyi M., Stephens G., Durant L., Watford W. T., Laurence A., Robinson G. W., Shevach E. M., Moriggl R., Hennighausen L., Wu C., O'Shea J. J., Nonredundant roles for Stat5a/b in directly regulating Foxp3, 10.1182/blood-2006-11-055756
  19. Ding Yi, Shen Shiqian, Lino Andreia C, Curotto de Lafaille Maria A, Lafaille Juan J, Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells, 10.1038/nm1707
  20. Steenwinckel V., Louahed J., Orabona C., Huaux F., Warnier G., McKenzie A., Lison D., Levitt R., Renauld J.-C., IL-13 Mediates In Vivo IL-9 Activities on Lung Epithelial Cells but Not on Hematopoietic Cells, 10.4049/jimmunol.178.5.3244
  21. Van Snick J., Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40), 10.1084/jem.169.1.363
  22. Uyttenhove C., Simpson R. J., Van Snick J., Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity., 10.1073/pnas.85.18.6934
  23. Komiyama Y., Nakae S., Matsuki T., Nambu A., Ishigame H., Kakuta S., Sudo K., Iwakura Y., IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis, 10.4049/jimmunol.177.1.566
  24. Yen David, Cheung Jeanne, Scheerens Heleen, Poulet Frédérique, McClanahan Terrill, Mckenzie Brent, Kleinschek Melanie A., Owyang Alex, Mattson Jeanine, Blumenschein Wendy, Murphy Erin, Sathe Manjiri, Cua Daniel J., Kastelein Robert A., Rennick Donna, IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6, 10.1172/jci21404
  25. Bettelli Estelle, Sullivan Brandon, Szabo Susanne J., Sobel Raymond A., Glimcher Laurie H., Kuchroo Vijay K., Loss of T-bet, But Not STAT1, Prevents the Development of Experimental Autoimmune Encephalomyelitis, 10.1084/jem.20031819
  26. Chitnis Tanuja, Najafian Nader, Benou Christina, Salama Alan D., Grusby Michael J., Sayegh Mohamed H., Khoury Samia J., Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis, 10.1172/jci200112563
  27. Kaplan Mark H., Sun Ya-Lin, Hoey Timothy, Grusby Michael J., Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice, 10.1038/382174a0
  28. Szabo Susanne J, Kim Sean T, Costa Gina L, Zhang Xiankui, Fathman C.Garrison, Glimcher Laurie H, A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment, 10.1016/s0092-8674(00)80702-3
  29. McGeachy Mandy J, Bak-Jensen Kristian S, Chen Yi, Tato Cristina M, Blumenschein Wendy, McClanahan Terrill, Cua Daniel J, TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology, 10.1038/ni1539
  30. 13, 715 (2000)
  31. 26, 371 (2007)
  32. Xiao S., Jin H., Korn T., Liu S. M., Oukka M., Lim B., Kuchroo V. K., Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF- -Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression, 10.4049/jimmunol.181.4.2277
  33. LEJEUNE Diane, DEMOULIN Jean-Baptiste, RENAULD Jean-Christophe, Interleukin 9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin 9 signalling, 10.1042/bj3530109
  34. 28, 112 (2008)
  35. Battle T., Frank D., The Role of STATs in Apoptosis, 10.2174/1566524023362456
  36. Bettelli Estelle, Pagany Maria, Weiner Howard L., Linington Christopher, Sobel Raymond A., Kuchroo Vijay K., Myelin Oligodendrocyte Glycoprotein–specific T Cell Receptor Transgenic Mice Develop Spontaneous Autoimmune Optic Neuritis, 10.1084/jem.20021603