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A comprehensive study on the inclusion mechanism of benzophenone into supramolecular nanoassemblies prepared using two water-soluble associative polymers

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Bouchemal, Kawthar Couvreur, Patrick [UCL] Daoud-Mahammed, Samia Poupaert, Jacques [UCL] Gref, Ruxandra

In this study, the entrapment of benzophenone (BZ) into supramolecular nanoassemblies prepared by mixing two water-soluble associative polymers (i.e. polymerized beta-CD (p beta-CD) and dextran grafted with lauryl-side chains (MD)) has been investigated by using isothermal titration microcalorimetry (ITC) and molecular modeling. ITC experiments have been performed at various temperatures (4 degrees C (277 K), 25 degrees C (298 K), and 37 degrees C (310 K)) to evaluate the interaction of BZ with p beta-CD in comparison with beta-CD. The inclusion complexation for both beta-CD/BZ and p beta-CD/BZ interactions was entropy-driven (vertical bar Delta H vertical barvertical bar T Delta S vertical bar) when the temperature of the experiment was low (4 degrees C) and enthalpy-driven (vertical bar Delta H vertical bar>vertical bar T Delta S vertical bar) with minor entropic contribution when the temperature was increased (25 and 37 degrees C). Using all the thermodynamic data obtained for beta-CD/BZ and beta b-CD/BZ interactions when the temperature of the experiment was varied, the Delta H = f (T Delta S) plot was perfectly linear, which reflected an enthalpy-entropy compensation process. Finally, the combination of ITC data with molecular modeling provided consistent information in regard to the location of MD side chains and BZ inside the cyclodextrin cavity, as well as concerning the stability of the nanoassemblies loaded with BZ.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2009
Language Anglais
Journal information "Journal of Thermal Analysis and Calorimetry : an international forum for thermal studies" - Vol. 98, no. 1, p. 57-64 (2009)
Peer reviewed yes
Publisher Springer (Dordrecht)
issn 1388-6150
e-issn 1572-8943
Publication status Publié
Affiliation UCL - MD/FARM - Ecole de pharmacie
Keywords Isothermal titration microcalorimetry ; Benzophenone ; Cyclodextrins ; Inclusion complexes ; Heat capacity
Links
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Bibliographic reference Bouchemal, Kawthar ; Couvreur, Patrick ; Daoud-Mahammed, Samia ; Poupaert, Jacques ; Gref, Ruxandra. A comprehensive study on the inclusion mechanism of benzophenone into supramolecular nanoassemblies prepared using two water-soluble associative polymers. In: Journal of Thermal Analysis and Calorimetry : an international forum for thermal studies, Vol. 98, no. 1, p. 57-64 (2009)
Permanent URL http://hdl.handle.net/2078.1/35199