User menu

Current advances in Phellinus sensu lato: medicinal species, functions, metabolites and mechanisms

Bibliographic reference Dai, Yu-Cheng ; Zhou, Li-Wei ; Cui, Bao-Kai ; Chen, Yan-Qiu ; Decock, Cony. Current advances in Phellinus sensu lato: medicinal species, functions, metabolites and mechanisms. In: Applied Microbiology and Biotechnology, Vol. 87, no. 5, p. 1587-1593 (2010)
Permanent URL
  1. Ajith TA, Janardhanan KK (2002) Antioxidant and antihepatotoxic activities of Phellinus rimosus (Berk) Pilat. J Ethnopharmacol 81:387–391
  2. Ajith TA, Janardhanan KK (2007) Indian medicinal mushrooms as a source of antioxidant and antitumor agents. J Clin Biochem Nutr 40:157–162
  3. Anonymous (1955) Shen Nong materia medica, 102–200 a.d (E. Han). Reprinted. People’s Hygiene Press, Beijing
  4. Bae JS, Jang KH, Yim H, Jin HK (2005a) Polysaccharides isolated from Phellinus gilvus inhibit melanoma growth in mice. Cancer Lett 218:43–52
  5. Bae Jae-Sung, Inhibitory effects of polysaccharides isolated fromPhellinus gilvuson benzo(a)pyrene-induced forestomach carcinogenesis in mice, 10.3748/wjg.v11.i4.577
  6. Baker JR, Kim JS, Park SY (2008) Composition and proposed structure of a water-soluble glycan from the Keumsa Sangwhang mushroom (Phellinus linteus). Fitoterapia 79:345–350
  7. Chang ZQ, Oh BC, Rhee MH, Kim JC, Lee SP, Park SC (2007) Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages. World J Microbiol Biotechnol 23:723–727
  8. Collins L, Zhu T, Guo J, Xiao ZJ, Chen CY (2006) Phellinus linteus sensitises apoptosis induced by doxorubicin in prostate cancer. Br J Cancer 95:282–288
  9. Dai YC (1999) Phellinus sensu lato (Aphyllophorales, Hymenochaetaceae) in East Asia. Acta Bot Fenn 166:1–115
  10. Dai YC (2003) New knowledge on the medicinal basidiomycetes Phellinus baumii Pilát. Zhōngcǎoyào 34:94–95
  11. Dai YC, Tolgor (2007) Illustrations of edible and medicinal fungi in Northeastern China. Science Press, Beijing
  12. Dai YC, Yang ZL (2008) A revised checklist of medicinal fungi in China. Mycosystema 27:801–824
  13. Dai YC, Yang ZL, Cui BK, Yu CJ, Zhou LW (2009) Species diversity and utilization of medicinal mushrooms and fungi in China (review). Int J Med Mushr 11:287–302
  14. Folkman J (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1:27–31
  15. Fukushima M (1989) The overdose of drugs in Japan. Nature 342:850–851
  16. Ge Q, Zhang AQ, Sun PL (2009) Structural investigation of a novel water-soluble heteropolysaccharide from the fruiting bodies of Phellinus baumii Pilát. Food Chem 114:391–395
  17. Hao RX, Zhou S, Yang Y, Xi JZ, Li WY, Tang QJ, Wang CG (2008) Flavone content and bioactivity of aqueous-ethanolic extracts of Phellinus fruit bodies. Aata Edulis Fungi 15:27–30
  18. Hwang HJ, Kim SW, Lim JM, Joo JH, Kim HO, Kim HM, Yun JW (2005) Hypoglycemic effect of crude exopolysaccharides produced by a medicinal mushroom Phellinus baumii in streptozotocin-induced diabetic rats. Life Sci 76:3069–3080
  19. Ikekawa T, Nakanishi M, Uehara N, Chihara G, Fukuoka F (1968) Antitumor action of some Basidiomycetes, especially Phllinus linteus. Gann 59:155–157
  20. Issemann I, Green S (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347:645–650
  21. Jang BS, Kim JC, Bae JS, Rhee MH, Jang KH, Song JC, Kwon OD, Park SC (2004) Extracts of Phellinus gilvus and Phellinus baumii inhibit pulmonary inflammation induced by lipopolysaccharide in rats. Biotechnol Lett 26:31–33
  22. Jung JY, Lee IK, Seok SJ, Lee HJ, Kim YH, Yun BS (2008) Antioxidant polyphenols from the mycelial culture of the medicinal fungi Inonotus xeranticus and Phellinus linteus. J Appl Microbiol 104:1824–1832
  23. Kim GY, Kim SH, Hwang SY, Kim HY, Park YM, Park SK, Lee MK, Lee SH, Lee TH, Lee JD (2003a) Oral administration of proteoglycan isolated from Phellinus linteus in the prevention and treatment of collagen-induced arthritis in mice. Biol Pharm Bull 26:823–831
  24. Kim GY, Park HS, Nam BH, Lee SJ, Lee JD (2003b) Purification and characterization of acidic proteo-heteroglycan from the fruiting body of Phellinus linteus (Berk. & M.A. Curtis) Teng. Bioresour Technol 89:81–87
  25. Kim GY, Park SK, Lee MK, Lee SH, Oh YH, Kwak JY, Yoon S, Lee JD, Park YM (2003c) Proteoglycan isolated from Phellinus linteus activates murine B lymphocytes via protein kinase C and protein tyrosine kinase. Int Immunopharmacol 3:1281–1292
  26. Kim GY, Roh SI, Park SK, Ahn SC, Oh YH, Lee JD, Park YM (2003d) Alleviation of experimental septic shock in mice by acidic polysaccharide isolated from the medicinal mushroom Phellinus linteus. Biol Pharm Bull 26:1418–1423
  27. Kim GY, Choi GS, Lee SH, Park YM (2004) Acidic polysaccharide isolated from Phellinus linteus enhances through the up-regulation of nitric oxide and tumor necrosis factor-alpha from peritoneal macrophages. J Ethnopharmacol 95:69–76
  28. Larsen MJ, Cobb-Poulle LA (1990) Phellinus (Hymenochaetaceae). A survey of the world taxa. Synop Fungorum 3:1–206
  29. Larsson K-H, Parmasto E, Fischer M, Langer E, Nakasone KK, Redhead SA (2006) Hymenochaetales: a molecular phylogeny for the hymenochaetoid clade. Mycologia 98:926–936
  30. Lee KH (2004) Current developments in the discovery and design of new drug candidates from plant natural product leads. J Nat Prod 67:273–283
  31. Lee IK, Yun BS (2007) Highly oxygenated and unsaturated metabolites providing a diversity of hispidin class antioxidants in the medicinal mushrooms Inonotus and Phellinus. Bioorg Med Chem 15:3309–3314
  32. Lee IK, Seok SJ, Kim WK, Yun BS (2006) Hispidin derivatives from the mushroom Inonotus xeranticus and their antioxidant activity. J Nat Prod 69:299–301
  33. Lee IK, Lee JH, Yun BS (2008a) Polychlorinated compounds with PPAR-gamma agonistic effect from the medicinal fungus Phellinus ribis. Bioorg Med Chem Lett 18:4566–4568
  34. Lee YS, Kang YH, Jung JY, Kang IJ, Han SN, Chung JS, Shin HK, Lim SS (2008b) Inhibitory constituents of aldose reductase in the fruiting body of Phellinus linteus. Biol Pharm Bull 31:765–768
  35. Li SZ (1957) Compendium materia medica, 1578. Commercial Press, Beijing (reprinted)
  36. Li X, Jiao L, Zhang X, Tian W, Chen S, Zhang L (2008) Structure of polysaccharides from mycelium and culture medium of Phellinus nigricans using submerged fermentation. Sci China C Life Sci 51:513–519
  37. Liu B (1984) The Chinese medical fungi. Shanxi People’s Press, Taiyuan
  38. Liu JK (2004) Mycochemistry. China Science and Technology Press, Beijing
  39. Mao XL (1989) The edible and medicinal macrofungi in China. Microbiology 16:290–297
  40. Mao XL (1998) Economic fungi of China. Science Press, Beijing
  41. Mo SY, Yang YC, Shi JG (2003) Studies on chemical constitutes of Phellinus igniarius. China J Chin Mater Med 28:339–341
  42. Mo S, Wang S, Zhou G, Yang Y, Li Y, Chen X, Shi J (2004) Phelligridins C-F: cytotoxic pyrano[4, 3-c][2]benzopyran-1, 6-dione and furo[3, 2-c]pyran-4-one derivatives from the fungus Phellinus igniarius. J Nat Prod 67:823–828
  43. Murphy GJ, Holder JC (2000) PPAR-gamma agonists: therapeutic role in diabetes, inflammation and cancer. Trends Pharmacol Sci 21:469–474
  44. Pan XR, Zou L, Hu YY, Yu HL, Zhang WY (2008) Discussion on the species of Sanghuang in East Asia. Edible Fungi China 27:63–67
  45. Park HG, Shim YY, Choi SO, Park WM (2009) New method development for nanoparticle extraction of water-soluble beta-(1→3)-d-glucan from edible mushrooms, Sparassis crispa and Phellinus linteus. J Agric Food Chem 57:2147–2154
  46. Peng YC, Zheng WF, Chen CF, Gao XW, Tian GF, Zong ZM, Wei XY (2006) Preliminary investigation of antitumor effect of a macrofungus, Phellinus chrysoloma (Fr.) Donk. China Sci Technol Inf 5:101–102
  47. Price JT, Bonovich MT, Kohn EC (1997) The biochemistry of cancer dissemination. Crit Rev Biochem Mol Biol 32:175–253
  48. Shon MY, Kim TH, Sung NJ (2003) Antioxidants and free radical scavenging activity of Phellinus baumii (Phellinus of Hymenochaetaceae) extracts. Food Chem 82:593–597
  49. Sliva D, Jedinak A, Kawasaki J, Harvey K, Slivova V (2008) Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling. Br J Cancer 98:1348–1356
  50. Sun PL, Xu SY, Yang K, Zhang J, Song L (2006) Advance of researches on Phellinus spp. A rare and precious medicinal fungus. Microbiology 33:119–123
  51. Tao MH, Zhang WM, Zhong H, Li HH (2005) Review on the research of medicinal fungi in the genus Phellinus. Acta Edulis Fungi 12:65–72
  52. Wang Y, Wang SJ, Mo SY, Li S, Yang YC, Shi JG (2005) Phelligridimer A, a highly oxygenated and unsaturated 26-membered macrocyclic metabolite with antioxidant activity from the fungus Phellinus igniarius. Org Lett 7:4733–4736
  53. Wang Y, Shang XY, Wang SJ, Mo SY, Li S, Yang YC, Ye F, Shi JG, He L (2007) Structures, biogenesis, and biological activities of pyrano[4, 3-c]isochromen-4-one derivatives from the fungus Phellinus igniarius. J Nat Prod 70:296–299
  54. Wasser SP (2002) Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol 60:258–274
  55. Wu MJ, Jiang DZ, Liu TM, Zhang LP (2006) Structural analysis of water-soluble polysaccharide PIP1 extracted from the cultured mycelium of Phellinus igniarius. Chem Res Chin Univ 22:708–711
  56. Yang Y, Zhang J, Liu Y, Tang Q, Zhao Z, Xia W (2007) Structural elucidation of a 3-O-methyl-d-galactose-containing neutral polysaccharide from the fruiting bodies of Phellinus igniarius. Carbohydr Res 342:1063–1070
  57. Yang Y, Ye L, Zhang J, Liu Y, Tang Q (2009) Structural analysis of a bioactive polysaccharide, PISP1, from the medicinal mushroom Phellinus igniarius. Biosci Biotechnol Biochem 73:134–139
  58. Ying J, Mao X, Ma Q (1987) Icons of medicinal fungi from China. Science Press, Beijing
  59. Zaidman BZ, Yassin M, Mahajna J, Wasser SP (2005) Medicinal mushroom modulators of molecular targets as cancer therapeutics. Appl Microbiol Biotechnol 67:453–468
  60. Zhang WG, Hu JH, Cai Z, Ji YP, Huang J (2002) Anti-hepatic fibrosis and anti-lipid peroxidation effects of Phellinus igniarius on rat liver. Chin Trad Pat Med 24:281–283
  61. Zhang M, Ji XG, Bei ZC, Zheng CG, Wang JY (2006) Studies on the anti-tumor activity of Phellinus linteus. Pharmacol Clin Chin Mater Med 22:56–58
  62. Zhao JZ (1996) The resources and application of medicinal fungi from forests. For Sci Technol 5:40–41
  63. Zhu T, Guo J, Collins L, Kelly J, Xiao ZJ, Kim SH, Chen CY (2007) Phellinus linteus activates different pathways to induce apoptosis in prostate cancer cells. Br J Cancer 96:583–590
  64. Zou X, Sun M, Guo X (2006) Quantitative response of cell growth and polysaccharide biosynthesis by the medicinal mushroom Phellinus linteus to NaCl in the medium. World J Microbiol Biotechnol 22:1129–1133
  65. Zou X, Guo X, Sun M (2009) pH control strategy in a shaken minibioreactor for polysaccharide production by medicinal mushroom Phellinus linteus and its anti-hyperlipemia activity. Bioprocess Biosyst Eng 32:277–281