User menu

Iron and the immune system

Bibliographic reference Ward, Roberta J. ; Crichton, Robert ; Taylor, Deanna L ; Corte, Laura Della ; Srai, Surjit K ; et. al. Iron and the immune system. In: Journal of Neural Transmission. General Section, Vol. 118, no. 3, p. 315-328 (2011)
Permanent URL
  1. Baranano D. E., Snyder S. H., Neural roles for heme oxygenase: Contrasts to nitric oxide synthase, 10.1073/pnas.191351298
  2. Bayele H. K., Peyssonnaux C., Giatromanolaki A., Arrais-Silva W. W., Mohamed H. S., Collins H., Giorgio S., Koukourakis M., Johnson R. S., Blackwell J. M., Nizet V., Srai S. K. S., HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite, 10.1182/blood-2006-12-063289
  3. Bullen J. J., Hemochromatosis, iron and septicemia caused by Vibrio vulnificus, 10.1001/archinte.151.8.1606
  4. Chan W.Y., Kohsaka S., Rezaie P., The origin and cell lineage of microglia—New concepts, 10.1016/j.brainresrev.2006.11.002
  5. Crichton RR, Dexter DT, Ward RJ (2010) Brain iron metabolism and its perturbation in neurological disease J Neural Trans (submitted)
  6. Cramer Thorsten, Yamanishi Yuji, Clausen Björn E., Förster Irmgard, Pawlinski Rafal, Mackman Nigel, Haase Volker H., Jaenisch Rudolf, Corr Maripat, Nizet Victor, Firestein Gary S., Gerber Hans-Peter, Ferrara Napoleone, Johnson Randall S., HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation, 10.1016/s0092-8674(03)00154-5
  7. Crichton RR (2009) Inorganic biochemistry of iron from molecular mechanisms to clinical consequences, 3rd edn. Wiley, Chichester, p 461
  8. Dissanayake DS, Kumarasiri PV, Nugegoda DB, Dissanayake DM (2009) The association of iron status with educational performance and intelligence among adolescents. Ceylon Med J 54:75–79
  9. Doherty CP (2007) Host–pathogen interactions: the role of iron. J Nutr 137:1341–1344
  10. Drakesmith H., Chen N., Ledermann H., Screaton G., Townsend A., Xu X.-N., HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis, 10.1073/pnas.0504823102
  11. Engelhart Marianne J., Geerlings Mirjam I., Meijer John, Kiliaan Amanda, Ruitenberg Annemieke, van Swieten John C., Stijnen Theo, Hofman Albert, Witteman Jacqueline C. M., Breteler Monique M. B., Inflammatory Proteins in Plasma and the Risk of Dementia : The Rotterdam Study, 10.1001/archneur.61.5.668
  12. Ferrucci L., Semba R. D., Guralnik J. M., Ershler W. B., Bandinelli S., Patel K. V., Sun K., Woodman R. C., Andrews N. C., Cotter R. J., Ganz T., Nemeth E., Longo D. L., Proinflammatory state, hepcidin, and anemia in older persons, 10.1182/blood-2009-02-201087
  13. Gerhard GS, Levin KA, Goldstien J, Wojnar MM, Chorney MJ, Belchis DA (2001) Vibrio vulnificus septicaemia in a patient with the haemochromatosis HFE C282Y mutation. Arch Pathol Lab Med 125:1107–1109
  14. Gimeno D., Kivimäki M., Brunner E. J., Elovainio M., De Vogli R., Steptoe A., Kumari M., Lowe G. D. O., Rumley A., Marmot M. G., Ferrie J. E., Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study, 10.1017/s0033291708003723
  15. Goetz David H, Holmes Margaret A, Borregaard Niels, Bluhm Martin E, Raymond Kenneth N, Strong Roland K, The Neutrophil Lipocalin NGAL Is a Bacteriostatic Agent that Interferes with Siderophore-Mediated Iron Acquisition, 10.1016/s1097-2765(02)00708-6
  16. Gordeuk VR, Ballou S, Lozanski G, Brittenham GM (1992) Decreased concentrations of tumor necrosis factor-alpha in supernatants of monocytes from homozygotes for hereditary hemochromatosis. Blood 79:1855–1860
  17. Graeber Manuel B., Streit Wolfgang J., Microglia: biology and pathology, 10.1007/s00401-009-0622-0
  18. Guerreiro Rita João, Santana Isabel, Brás José Miguel, Santiago Beatriz, Paiva Artur, Oliveira Catarina, Peripheral Inflammatory Cytokines as Biomarkers in Alzheimer’s Disease and Mild Cognitive Impairment, 10.1159/000107700
  19. Halterman J. S., Kaczorowski J. M., Aligne C. A., Auinger P., Szilagyi P. G., Iron Deficiency and Cognitive Achievement Among School-Aged Children and Adolescents in the United States, 10.1542/peds.107.6.1381
  20. Kaltschmidt B., Kaltschmidt C., Constitutive NF-κB activity is modulated via neuron-astroglia interaction, 10.1007/s002210050011
  21. Krause Alexander, Neitz Susanne, Mägert Hans-Jürgen, Schulz Axel, Forssmann Wolf-Georg, Schulz-Knappe Peter, Adermann Knut, LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity, 10.1016/s0014-5793(00)01920-7
  22. Kreutzberg Georg W, Microglia: a sensor for pathological events in the CNS, 10.1016/0166-2236(96)10049-7
  23. Lee P., Peng H., Gelbart T., Beutler E., The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and  2-microglobulin-deficient hepatocytes, 10.1073/pnas.0403108101
  24. Lee P., Peng H., Gelbart T., Wang L., Beutler E., Regulation of hepcidin transcription by interleukin-1 and interleukin-6, 10.1073/pnas.0409808102
  25. Legrand Dominique, Mazurier Joël, A critical review of the roles of host lactoferrin in immunity, 10.1007/s10534-010-9297-1
  26. Liu Xiao-Bing, Nguyen Ngoc-Bich H., Marquess Kimberly D., Yang Funmei, Haile David J., Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages, 10.1016/j.bcmd.2005.04.006
  27. Loiarro M, Ruggiero V, Sette C (2010) Targeting TLR/IL-1R signalling in human disease. Mediators Inflamm. doi: 10.1155/2010/674363
  28. Magaki Shino, Yellon Steven M., Mueller Claudius, Kirsch Wolff M., Immunophenotypes in the circulation of patients with mild cognitive impairment, 10.1016/j.jpsychires.2007.01.004
  29. McDonald CJ, Jones MK, Wallace DF, Summerville L, Nawaratna S, Subramaniam VN (2010) Increased iron stores correlates with worse disease outcomes in a mouse model of Schistosomiasis infection. PloS ONE 5(3):e9594 doi: 10.1371/journal.pone.0009594
  30. Moura E, Noordermeer MA, Verhoeven N, Verheul AF, Marx JJ (1998) Iron release from human monocytes after erythrophagocytosis in vitro: an investigation in normal subjects and hereditary hemochromatosis patients. Blood 92:2511–2519
  31. Muckenthaler Martina U., Fine Tuning of Hepcidin Expression by Positive and Negative Regulators, 10.1016/j.cmet.2008.06.009
  32. Nairz Manfred, Theurl Igor, Ludwiczek Susanne, Theurl Milan, Mair Sabine M., Fritsche Gernot, Weiss Günter, The co-ordinated regulation of iron homeostasis in murine macrophages limits the availability of iron for intracellularSalmonella typhimurium, 10.1111/j.1462-5822.2007.00942.x
  33. Nairz Manfred, Fritsche Gernot, Brunner Peter, Talasz Heribert, Hantke Klaus, Weiss Günter, Interferon‐γ limits the availability of iron for intramacrophageSalmonella typhimurium, 10.1002/eji.200738056
  34. Nairz M., Theurl I., Schroll A., Theurl M., Fritsche G., Lindner E., Seifert M., Crouch M.-L. V., Hantke K., Akira S., Fang F. C., Weiss G., Absence of functional Hfe protects mice from invasive Salmonella enterica Serovar Typhimurium infection via induction of lipocalin-2, 10.1182/blood-2009-05-223354
  35. Nemeth Elizabeta, Rivera Seth, Gabayan Victoria, Keller Charlotte, Taudorf Sarah, Pedersen Bente K., Ganz Tomas, IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin, 10.1172/jci200420945
  36. Niederkofler V., Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload, 10.1172/jci25683
  37. Olakanmi Oyebode, Schlesinger Larry S., Ahmed Ambar, Britigan Bradley E., IntraphagosomalMycobacterium tuberculosisAcquires Iron from Both Extracellular Transferrin and Intracellular Iron Pools : IMPACT OF INTERFERON-γ AND HEMOCHROMATOSIS, 10.1074/jbc.m209768200
  38. Olakanmi O., Schlesinger L. S., Britigan B. E., Hereditary hemochromatosis results in decreased iron acquisition and growth by Mycobacterium tuberculosis within human macrophages, 10.1189/jlb.0606405
  39. Oppenheimer SJ (2001) Iron and its relation to immunity and infectious disease. J Nutr 131:616S–633S
  40. Pan X, Tamilselvam B, Hansen EJ, Daefler S (2010) Modulation of iron homeostasis in macrophages by bacterial intracellular pathogens. BMC Microbiol 10:64
  41. Park Christina H., Valore Erika V., Waring Alan J., Ganz Tomas, Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver, 10.1074/jbc.m008922200
  42. Peyssonnaux Carole, Datta Vivekanand, Cramer Thorsten, Doedens Andrew, Theodorakis Emmanuel A., Gallo Richard L., Hurtado-Ziola Nancy, Nizet Victor, Johnson Randall S., HIF-1α expression regulates the bactericidal capacity of phagocytes, 10.1172/jci23865
  43. Peyssonnaux C., TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens, 10.1182/blood-2005-06-2259
  44. Porto Graça, Iron overload and immunity, 10.3748/wjg.v13.i35.4707
  45. Ray Sandip, Britschgi Markus, Herbert Charles, Takeda-Uchimura Yoshiko, Boxer Adam, Blennow Kaj, Friedman Leah F, Galasko Douglas R, Jutel Marek, Karydas Anna, Kaye Jeffrey A, Leszek Jerzy, Miller Bruce L, Minthon Lennart, Quinn Joseph F, Rabinovici Gil D, Robinson William H, Sabbagh Marwan N, So Yuen T, Sparks D Larry, Tabaton Massimo, Tinklenberg Jared, Yesavage Jerome A, Tibshirani Robert, Wyss-Coray Tony, Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins, 10.1038/nm1653
  46. Rioux France M., LeBlanc Caroline P., Iron supplementation during pregnancy: what are the risks and benefits of current practices?, 10.1139/h07-012
  47. Roy Cindy N, Custodio Ángel O, de Graaf Jos, Schneider Susanne, Akpan Imo, Montross Lynne K, Sanchez Mayka, Gaudino Alessandro, Hentze Matthias W, Andrews Nancy C, Muckenthaler Martina U, An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice, 10.1038/ng1350
  48. Silvestri L., Pagani A., Camaschella C., Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis, 10.1182/blood-2007-07-100677
  49. Sow F. B., Florence W. C., Satoskar A. R., Schlesinger L. S., Zwilling B. S., Lafuse W. P., Expression and localization of hepcidin in macrophages: a role in host defense against tuberculosis, 10.1189/jlb.0407216
  50. Stolzfus R, Dreyfuss M (1988) International Nutritional Anaemia Consultative Group. ILSI Press, Washington, DC
  51. Tacchini Lorenza, Gammella Elena, De Ponti Cristina, Recalcati Stefania, Cairo Gaetano, Role of HIF-1 and NF-κB Transcription Factors in the Modulation of Transferrin Receptor by Inflammatory and Anti-inflammatory Signals, 10.1074/jbc.m800365200
  52. Theurl Igor, Finkenstedt Armin, Schroll Andrea, Nairz Manfred, Sonnweber Thomas, Bellmann-Weiler Rosa, Theurl Milan, Seifert Markus, Wroblewski Victor J., Murphy Anthony T., Witcher Derrick, Zoller Heinz, Weiss Günter, Growth differentiation factor 15 in anaemia of chronic disease, iron deficiency anaemia and mixed type anaemia, 10.1111/j.1365-2141.2009.07961.x
  53. Wang Lijian, Cherayil Bobby J., Ironing Out the Wrinkles in Host Defense: Interactions between Iron Homeostasis and Innate Immunity, 10.1159/000210016
  54. Wang L., Johnson E. E., Shi H. N., Walker W. A., Wessling-Resnick M., Cherayil B. J., Attenuated Inflammatory Responses in Hemochromatosis Reveal a Role for Iron in the Regulation of Macrophage Cytokine Translation, 10.4049/jimmunol.181.4.2723
  55. Wang L, Harrington L, Trebicka E, Shi HN, Kagan JC, Hong CC, Lin HY, Babitt JL, Cherayil BJ (2009) Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. J Clin Invest 119:3322–3328
  56. Ward Roberta J., Wilmet Stephanie, Legssyer Rachida, Leroy Daniel, Toussaint Louise, Crichton Robert R., Pierreux Christophe, Hue Louis, Piette Jacques, Srai Surjit Kaila, Solanky Nita, Klein Dominique, Summer Karl, Effects of marginal iron overload on iron homeostasis and immune function in alveolar macrophages isolated from pregnant and normal rats, 10.1007/s10534-008-9155-6
  57. Wessling-Resnick Marianne, Iron Homeostasis and the Inflammatory Response, 10.1146/annurev.nutr.012809.104804