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Whole-body MRI (WB-MRI) versus axial skeleton MRI (AS-MRI) to detect and measure bone metastases in prostate cancer (PCa).

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Lecouvet, Frédéric [UCL] Simon, M. [UCL] Tombal, Bertrand [UCL] Jamart, Jacques [UCL] Vande Berg, Bruno [UCL] Simoni, Paolo [UCL]

OBJECTIVE: To compare whole-body MRI (WB-MRI) and axial skeleton MRI (AS-MRI) in detecting and measuring bone metastases in patients with prostate cancer (PCa). METHODS: WB-MRI and AS-MRI examinations were performed in 60 patients with PCa at high risk of metastases. Two radiologists separately categorised the AS-MRI and WB-MRI as negative or positive for metastases, and measured focal metastases using the "Response evaluation criteria in solid tumours" (RECIST) criteria transposed to bone. One radiologist reviewed all examinations 2 months later. Inter- and intraobserver agreements in establishing the presence/absence of metastases were calculated. Bland-Altman plots were used to assess measurement agreement between AS-MRI and WB-MRI. RESULTS: Strong to perfect inter- and intraobserver agreements were found between AS-MRI and WB-MRI in defining the presence/absence of bone metastases. There were no patients with isolated "peripheral" metastases at WB-MRI, missed at AS-MRI. There was no difference in lesion count between the two radiologists. AS-MRI and WB-MRI provided statistically equivalent RECIST values for one radiologist and slightly lower values at AS-MRI for the other. CONCLUSIONS: In our series of PCa patients, AS-MRI and WB-MRI were equivalent in determining the presence/absence of bone metastases and provided similar evaluation of the metastatic burden.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2010
Journal information "European Radiology : journal of the European Congress of Radiology" - Vol. 20, no. 12, p. 2973-2982 (2010)
Peer reviewed yes
Publisher Springer ((Germany) Heidelberg)
issn 0938-7994
e-issn 1432-1084
Publication status Publié
Affiliations UCL - SSS/IREC - Institut de recherche expérimentale et clinique
UCL - (SLuc) Département d'imagerie médicale
UCL - (SLuc) Service de radiologie
UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation
UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale
UCL - SSS/IREC/MONT - Pôle Mont Godinne
UCL - (SLuc) Service d'urologie
UCL - (MGD) Unité de support scientifique
MESH Subject Whole Body Imaging - methods ; Sensitivity and Specificity ; Reproducibility of Results ; Prostatic Neoplasms - diagnosis ; Middle Aged ; Male ; Magnetic Resonance Imaging - methods ; Humans ; Bone and Bones - pathology ; Bone Neoplasms - diagnosis - secondary ; Aged, 80 and over ; Aged
Keywords Prostate ; Cancer ; Bone ; MRI ; Metastases
Links
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Bibliographic reference Lecouvet, Frédéric ; Simon, M. ; Tombal, Bertrand ; Jamart, Jacques ; Vande Berg, Bruno ; et. al. Whole-body MRI (WB-MRI) versus axial skeleton MRI (AS-MRI) to detect and measure bone metastases in prostate cancer (PCa).. In: European Radiology : journal of the European Congress of Radiology, Vol. 20, no. 12, p. 2973-2982 (2010)
Permanent URL http://hdl.handle.net/2078.1/33129