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No PDGF receptor signal in pericytes without endosialin?

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Demoulin, Jean-Baptiste [UCL]

Solid tumors contain non-transformed cells of critical importance for disease progression. These cells form the tumor stroma, including blood vessel and fibroblasts. Being more genetically stable than cancer cells, stromal cells have drawn much interest as potential therapeutic targets, leading to the concepts of anti-angiogenic and anti-stromal drugs. In this context, researchers have been seeking new stromal cell markers. Endosialin (CD248, TEM-1) and PDGF Receptor beta are two of them.

Document type Article de périodique (Journal article) – Journal Article
Access type Accès restreint
Publication date 2010
Language Anglais
Journal information "Cancer biology & therapy" - Vol. 9, no. 11, p. 916-8 (2010)
Peer reviewed yes
issn 1538-4047
e-issn 1555-8576
Publication status Publié
Affiliation UCL - SSS/DDUV - Institut de Duve
MESH Subject Signal Transduction ; Receptors, Platelet-Derived Growth Factor - genetics - metabolism ; RNA Interference ; Platelet-Derived Growth Factor - pharmacology ; Phosphorylation - drug effects ; Pericytes - cytology - drug effects - metabolism ; Models, Biological ; Mitogen-Activated Protein Kinase 3 - metabolism ; Mitogen-Activated Protein Kinase 1 - metabolism ; Humans ; Cell Proliferation ; Cell Line ; Antigens, Neoplasm - genetics - metabolism ; Antigens, CD - genetics - metabolism
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Bibliographic reference Demoulin, Jean-Baptiste. No PDGF receptor signal in pericytes without endosialin?. In: Cancer biology & therapy, Vol. 9, no. 11, p. 916-8 (2010)
Permanent URL http://hdl.handle.net/2078.1/32247