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Isolation and mass spectrometric identification of two metabolites of FK 506 from rat liver microsomal incubation media.

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Lhoëst, G Maton, Nicole [UCL] Verbeeck, Roger-K. [UCL]

A transient epoxide in equilibrium with its possible isomeric forms, most probably induced easily by neighboring-group assistance of a hydroxy group, and a dihydrodiol formed under the influence of the hydrase enzymic activity and/or by simple hydrolysis were isolated by HPLC and identified by FAB/MS from rat liver microsomal incubation media.

Document type Article de périodique (Journal article) – In Vitro, Journal Article
Publication date 1992
Journal information "Pharmaceutica acta Helvetiae" - Vol. 67, no. 9-10, p. 270-4 (1992)
Peer reviewed yes
issn 0031-6865
Publication status Publié
Affiliation UCL
MESH Subject Animals ; Male ; Microsomes, Liver - chemistry - enzymology - metabolism ; Rats ; Rats, Wistar ; Spectrometry, Mass, Fast Atom Bombardment ; Tacrolimus - analysis - metabolism
Links
Bibliographic reference Lhoëst, G ; Maton, Nicole ; Verbeeck, Roger-K.. Isolation and mass spectrometric identification of two metabolites of FK 506 from rat liver microsomal incubation media.. In: Pharmaceutica acta Helvetiae, Vol. 67, no. 9-10, p. 270-4 (1992)
Permanent URL http://hdl.handle.net/2078.1/29628