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Cytogenetic observations following thallium poisoning

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Hantson, Philippe [UCL] Desoir, Ria Léonard, Eliane D. Crutzen-Fayt, Marie-Christine Léonard, Alain [UCL] Mahieu, Paul

Observations have been performed on peripheral blood lymphocytes from a patient having ingested 200 mg thallium sulfate, in order to evaluate the ability of the compound to produce cytogenetic damage in vivo in humans. Our results demonstrate that neither the yield of structural chromosome aberrations nor sister chromatid exchanges were significantly modified. The drastic increase of binucleated cells with micronuclei indicates that thallium sulfate has in common with many metallic compounds the ability to interfere with chromosome distribution.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1997
Journal information "Journal of Toxicology and Environmental Health" - Vol. 50, no. 2, p. 97-100 (1997)
Peer reviewed yes
Publisher Taylor & Francis Inc.
issn 0098-4108
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service de soins intensifs
UCL - (SLuc) Centre de toxicologie clinique
MESH Subject Cell Nucleus - drug effects ; Cells, Cultured ; Chromosome Aberrations - genetics ; Humans ; Leukocytes - cytology - drug effects ; Male ; Micronuclei, Chromosome-Defective - drug effects ; Micronucleus Tests ; Middle Aged ; Rodenticides - poisoning ; Sister Chromatid Exchange - drug effects ; Thallium - poisoning
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Bibliographic reference Hantson, Philippe ; Desoir, Ria ; Léonard, Eliane D. ; Crutzen-Fayt, Marie-Christine ; Léonard, Alain ; et. al. Cytogenetic observations following thallium poisoning. In: Journal of Toxicology and Environmental Health, Vol. 50, no. 2, p. 97-100 (1997)
Permanent URL http://hdl.handle.net/2078.1/29589