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A historical perspective and cellular regulation of megakaryocytopoiesis.

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Baatout, SARAH [UCL]

With the recent accumulation of information about megakaryocyte biochemistry and function, our understanding of the regulatory system controlling megakaryocytopoiesis is becoming more clear. The cloning and the expression of thrombopoietin, the regulator of megakaryocytopoiesis, has been a major breakthrough. This review will discuss megakaryocyte ontogeny, cell-cell interactions between megakaryocytes and the other stromal cells and the signal transduction in megakaryocytes.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't, Review
Publication date 1998
Journal information "Haematologia" - Vol. 29, no. 2, p. 67-79 (1998)
Peer reviewed yes
issn 0017-6559
Publication status Publié
Affiliation UCL - MD/ESP - Ecole de santé publique
MESH Subject Animals ; Cell Communication ; Hematopoietic Stem Cells - physiology ; Humans ; Leukopoiesis ; Megakaryocytes - physiology ; Signal Transduction ; Thrombopoietin - physiology
Links
Bibliographic reference Baatout, SARAH. A historical perspective and cellular regulation of megakaryocytopoiesis.. In: Haematologia, Vol. 29, no. 2, p. 67-79 (1998)
Permanent URL http://hdl.handle.net/2078.1/29572