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Treatment with calcitonin suppresses the responses of bone, cartilage, and synovium in the early stages of canine experimental osteoarthritis and significantly reduces the severity of the cartilage lesions.

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Manicourt, Daniel Altman, Roy D [Department of Veterans Affairs Medical Center, and University of Miami School of Medicine, Miami, Florida] Williams, James M [Rush Medical College at Rush–Presbyterian–St. Luke's Medical Center, Chicago, Illinois] Devogelaer, Jean-Pierre [UCL] Druetz-Van Egerena, A Thonar, Eugen J. [Rush Medical College at Rush–Presbyterian–St. Luke's Medical Center, Chicago, Illinois]

OBJECTIVE: To relate the rate of bone resorption to serum levels of both hyaluronan (HA) and antigenic keratan sulfate (KS) in canine experimental osteoarthritis (OA) and to evaluate the effects of calcitonin on these parameters and the OA lesions of the unstable knee. METHODS: Twenty-two dogs underwent anterior cruciate ligament transection (ACLT) and 6 dogs underwent sham operation. Urinary pyridinium crosslinks were quantified by high-performance liquid chromatography. Immunoassays quantified hyaluronan (HA) and antigenic KS. Macroscopic and histologic OA lesions were scored. Calcitonin treatment was started on day 14 postsurgery and stopped on either day 49 or day 104 postsurgery. Control dogs and all treated dogs were killed on day 105. RESULTS: All ACLT joints developed OA. In contrast to sham-operated animals, all operated dogs exhibited an early and sustained rise in the levels of their urinary and serum markers. Calcitonin markedly reduced the levels of these markers and the severity of OA lesions. Furthermore, the longer the period of calcitonin therapy, the lower the score of the OA lesions. CONCLUSION: Bone, synovium, and articular cartilage all appear to be involved in the state of hypermetabolism that develops in unstable joints. Furthermore, the rate of bone resorption increases markedly in the early stages of this OA model and is likely to contribute to cartilage breakdown. Since calcitonin reduced the severity of OA changes, this form of therapy may have benefits for humans who have recently experienced a traumatic knee injury.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
Publication date 1999
Journal information "Arthritis and rheumatism" - Vol. 42, no. 6, p. 1159-67 (1999)
Peer reviewed yes
issn 0004-3591
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Amino Acids - urine ; Animals ; Anterior Cruciate Ligament - surgery ; Biological Markers - urine ; Bone Resorption - drug therapy ; Bone and Bones - drug effects ; Calcitonin - therapeutic use ; Cartilage, Articular - drug effects ; Chromatography, High Pressure Liquid ; Disease Models, Animal ; Dogs ; Hyaluronic Acid - blood ; Keratan Sulfate - blood ; Osteoarthritis - blood - drug therapy - pathology - urine ; Synovial Membrane - drug effects - pathology
Links
  1. McDevitt, J Bone Joint Surg Br, 59B, 24 (1977)
  2. Manicourt Daniel H., Thonar Eugene J-M, Pita Julio C., Howell David S., Changes in the Sedimentation Profile of Proteoglycan Aggregates in Early Experimental Canine Osteoarthritis, 10.3109/03008208909103902
  3. Akizuki Shaw, Mow Van C., Müller Francisco, Pita Julio C., Howell David S., Manicourt Daniel H., Tensile properties of human knee joint cartilage: I. Influence of ionic conditions, weight bearing, and fibrillation on the tensile modulus : TENSILE MODULUS OF HUMAN KNEE CARTILAGE, 10.1002/jor.1100040401
  4. Akizuki Shaw, Mow Van C., Muller Francisco, Pita Julio C., Howell David S., Tensile properties of human knee joint cartilage. II. Correlations between weight bearing and tissue pathology and the kinetics of swelling, 10.1002/jor.1100050204
  5. Müller Francisco J., Setton Lori A., Manicourt Daniel H., Mow Van C., Howell David S., Pita Julio C., Centrifugal and biochemical comparison of proteoglycan aggregates from articular cartilage in experimental joint disuse and joint instability : CARTILAGE PROTEOGLYCAN CHANGES AFTER ALTERED JOINT LOADING, 10.1002/jor.1100120406
  6. Setton L. A., Mow V. C., Müller F. J., Pita J. C., Howell D. S., Mechanical Properties of Canine Articular Cartilage Are Significantly Altered Following Transection of the Anterior Cruciate Ligament : CARTILAGE CHANGES AFTER TRANSECTION OF THE ANTERIOR CRUCIATE LIGAMENT, 10.1002/jor.1100120402
  7. Structure-function relationship of articular cartilage and the effects of joint instability and trauma on cartilage function. In: editor. Cartilage changes in osteoarthritis. Indianapolis: Indiana University School of Medicine; 1990. p. 22-43.
  8. Radin Eric L., Paul Jgor L., Importance of Bone in Sparing Articular Cartilage from Impact : , 10.1097/00003086-197107000-00031
  9. Radin, Clin Orthop, 213, 34 (1986)
  10. Burr David B., Schaffler Mitchell B., The involvement of subchondral mineralized tissues in osteoarthrosis: Quantitative microscopic evidence, 10.1002/(sici)1097-0029(19970515)37:4<343::aid-jemt9>3.0.co;2-l
  11. Manicourt, J Rheumatol, 18, 1872 (1991)
  12. Manicourt, J Rheumatol, 22, 262 (1995)
  13. Uebelhart Daniel, Gineyts Evelyne, Chapuy Marie-Claire, Delmas Pierre D., Urinary excretion of pyridinium crosslinks: a new marker of bone resorption in metabolic bone disease, 10.1016/0169-6009(91)90143-n
  14. Kusuzaki Katsuyuki, Kageyama Naoto, Shinjo Hironari, Murata Hiroaki, Takeshita Hideyuki, Ashihara Tsukasa, Hirasawa Yasusuke, A staining method for bone canaliculi, 10.3109/17453679508995514
  15. MANKIN HENRY J., DORFMAN HOWARD, LIPPIELLO LOUIS, ZARINS ANTRA, Biochemical and Metabolic Abnormalities in Articular Cartilage from Osteo-Arthritic Human Hips : II. CORRELATION OF MORPHOLOGY WITH BIOCHEMICAL AND METABOLIC DATA, 10.2106/00004623-197153030-00009
  16. Schlemmer, J Clin Endocrinol Metab, 74, 476 (1992)
  17. Black Darcey, Duncan Alexander, Robins Simon P., Quantitative analysis of the pyridinium crosslinks of collagen in urine using ion-paired reversed-phase high-performance liquid chromatography, 10.1016/0003-2697(88)90274-6
  18. Thonar Eugene J- M. A., Lenz Mary Ellen, Klintworth Gordon K., Caterson Bruce, Pachman Lauren M., Glickman Paul, Katz Robert, Huff John, Kuettner Klaus E., Quantification of keratan sulfate in blood as a marker of cartilage catabolism, 10.1002/art.1780281209
  19. Li Xiao-Qiang, Thonar Eugene J-M.A., Knudson Warren, Accumlation of Hyaluronate in Human Lung Carcinoma As Measured by A new Hyaluronate Elisa, 10.3109/03008208909043899
  20. UEBELHART D, THONAR E, PIETRYLA D, WILLIAMS J, Elevation in urinary levels of pyridinium cross-links of collagen following chymopapain-induced degradation of articular cartilage in the rabbit knee provides evidence of metabolic changes in bone, 10.1016/s1063-4584(05)80090-1
  21. Dedrick D. K., Goldstein S. A., Brandt K. D., O'Connor B. L., Goulet R. W., Albrecht M., A longitudinal study of subchondral plate and trabecular bone in cruciate-deficient dogs with osteoarthritis followed up for 54 months, 10.1002/art.1780361019
  22. Myers Stephen L., Brandt Kenneth D., O'Connor Brian L., Visco Denise M., Albrecht Marjorie E., Synovitis and osteoarthritic changes in canine articular cartilage after anterior cruciate ligament transection. Effect of surgical hemostasis, 10.1002/art.1780330913
  23. Brandt Kenneth D., Myers Stephen L., Burr David, Albrecht Marjorie, Osteoarthritic changes in canine articular cartilage, subchondral bone, and synovium fifty-four months after transection of the anterior cruciate ligament, 10.1002/art.1780341214
  24. O'connor Brian L., Visco Denise M., Heck David A., Myers Stephen L., Brandt Kenneth D., Gait alterations in dogs after transection of the anterior cruciate ligament, 10.1002/anr.1780320913
  25. Venn G., Nietfeld J. J., Duits A. J., Brennan F. M., Arner E., Covington M., Billingham M. E. J., Hardingham T. E., Elevated synovial fluid levels of interleukin-6 and tumor necrosis factor associated with early experimental canine osteoarthritis, 10.1002/art.1780360613
  26. Roodman G. David, Role of cytokines in the regulation of bone resorption, 10.1007/bf01673412
  27. Brown Thomas D., Radin Eric L., Martin R.Bruce, Burr David B., Finite element studies of some juxtarticular stress changes due to localized subchondral stiffening, 10.1016/0021-9290(84)90075-7
  28. Chrisman, Yale J Biol Med, 37, 409 (1965)
  29. FRANCHIMONT P., BASSLEER C., HENROTIN Y., GYSEN P., BASSLEER R., Effects of Human and Salmon Calcitonin on Human Articular Chondrocytes Cultivated in Clusters*, 10.1210/jcem-69-2-259
  30. Westacott Carole I., Webb Ginette R., Warnock Mark G., Sims Jane V., Elson Christopher J., Alteration of cartilage metabolism by cells from osteoarthritic bone, 10.1002/1529-0131(199707)40:7<1282::aid-art13>3.0.co;2-e
  31. Sharif Mohammed, George Emmanuel, Shepstone Lee, Knudson Warren, Thonar EUGENE J.-M. A., Cushnaghan Janet, Dieppe Paul, Serum hyaluronic acid level as a predictor of disease progression in osteoarthritis of the knee, 10.1002/art.1780380608
  32. HILLARBY M. C., CLARKSON R., GRENNAN D. M., BATE A. S., OLLIER W., SANDERS P. A., CHATTOPHADHYAY C., DAVIS M., O'SULLIVAN M. M., WILLIAMS B., IMMUNOGENETIC HETEROGENEITY IN RHEUMATOID DISEASE AS ILLUSTRATED BY DIFFERENT MHC ASSOCIATIONS (DQ, DW AND C4) IN ARTICULAR AND EXTRA-ARTICULAR SUBSETS, 10.1093/rheumatology/30.1.5
  33. Laurent Torvard C., Dahl Inger Marie S., Dahl Lauritz B., Engström-Laurent Anna, Eriksson Sigbritt, Fraser J. Robert E., Granath Kirsti A., Laurent Claude, Laurent Ulla B. G., Lilja Karin, Pertoft HÅKan, Smedsrød BÅRd, Tengblad Anders, Wik Ove, The Catabolic Fate of Hyaluronic Acid, 10.3109/03008208609001971
  34. Ludolph T, Paschke E, Glössl J, Kresse H, Degradation of keratan sulphate byβ-N-acetylhexosaminidases A and B, 10.1042/bj1930811
  35. Sinigaglia L, Varenna M, Binelli L, Bartucci F, Arrigoni M, Ferrara R, Abbiati G, Urinary and synovial pyridinium crosslink concentrations in patients with rheumatoid arthritis and osteoarthritis., 10.1136/ard.54.2.144
Bibliographic reference Manicourt, Daniel ; Altman, Roy D ; Williams, James M ; Devogelaer, Jean-Pierre ; Druetz-Van Egerena, A ; et. al. Treatment with calcitonin suppresses the responses of bone, cartilage, and synovium in the early stages of canine experimental osteoarthritis and significantly reduces the severity of the cartilage lesions.. In: Arthritis and rheumatism, Vol. 42, no. 6, p. 1159-67 (1999)
Permanent URL http://hdl.handle.net/2078.1/29359