User menu

Preclinical models for pulmonary drug delivery

  1. Anderson PJ, Respir Care, 50, 1139 (2005)
  2. Gagnadoux Frederic, Hureaux Jose, Vecellio Laurent, Urban Thierry, Le Pape Alain, Valo Isabelle, Montharu Jerome, Leblond Valerie, Boisdron-Celle Michele, Lerondel Stephanie, Majoral Caroline, Diot Patrice, Racineux Jean L., Lemarie Etienne, Aerosolized Chemotherapy, 10.1089/jamp.2007.0656
  3. Laube BL, Respir Care, 50, 1161 (2005)
  4. Durcan Niamh, Murphy Charlotte, Cryan Sally-Ann, Inhalable siRNA: Potential as a Therapeutic Agent in the Lungs, 10.1021/mp070048k
  5. Minne Antoine, Huaux François, Jaworska Joanna, Rha Ro-Dug, Hamelmann Eckard, Vanbever Rita, Safety evaluation of pulmonary influenza vaccination in healthy and “asthmatic” mice, 10.1016/j.vaccine.2008.02.062
  6. BIVASBENITA M, OTTENHOFF T, JUNGINGER H, BORCHARD G, Pulmonary DNA vaccination: Concepts, possibilities and perspectives, 10.1016/j.jconrel.2005.05.028
  7. Minne Antoine, Louahed Jamila, Mehauden Sybille, Baras Benoît, Renauld Jean-Christophe, Vanbever Rita, The delivery site of a monovalent influenza vaccine within the respiratory tract impacts on the immune response, 10.1111/j.1365-2567.2007.02641.x
  8. Patton John S., Byron Peter R., Inhaling medicines: delivering drugs to the body through the lungs, 10.1038/nrd2153
  9. Van Itallie Christina M., Anderson James M., CLAUDINS AND EPITHELIAL PARACELLULAR TRANSPORT, 10.1146/annurev.physiol.68.040104.131404
  10. Silin Dmytro S, Lyubomska Oksana V, Jirathitikal Vichai, Bourinbaiar Aldar S, Oral vaccination: where we are?, 10.1517/17425247.4.4.323
  11. Farr Stephen J., Otulana Babatunde A., Pulmonary delivery of opioids as pain therapeutics, 10.1016/j.addr.2006.07.013
  12. Armer T. A., Shrewsbury S. B., Newman S. P., Pitcairn G., Ramadan N., Aerosol delivery of ergotamine tartrate via a breath-synchronized plume-control inhaler in humans, 10.1185/030079907x242881
  13. Kling Jim, Inhaled insulin's last gasp?, 10.1038/nbt0508-479
  14. Bosquillon Cynthia, Préat Véronique, Vanbever Rita, Pulmonary delivery of growth hormone using dry powders and visualization of its local fate in rats, 10.1016/j.jconrel.2004.01.027
  15. Codrons Valérie, Vanderbist Francis, Ucakar Bernard, Préat Véronique, Vanbever Rita, Impact of formulation and methods of pulmonary delivery on absorption of parathyroid hormone (1–34) from rat lungs, 10.1002/jps.20053
  16. Dumont Jennifer A., Bitonti Alan J., Clark Darren, Evans Sean, Pickford Matthew, Newman Stephen P., Delivery of an Erythropoietin-Fc Fusion Protein by Inhalation in Humans through an Immunoglobulin Transport Pathway, 10.1089/jam.2005.18.294
  17. McWilliam Andrew S, Holt Patrick G, Immunobiology of dendritic cells in the respiratory tract: steady-state and inflammatory sentinels?, 10.1016/s0378-4274(98)00326-9
  18. Labiris N. R., Dolovich M. B., Pulmonary drug delivery. Part I: Physiological factors affecting therapeutic effectiveness of aerosolized medications : Physiological factors affecting the effectiveness of inhaled drugs, 10.1046/j.1365-2125.2003.01892.x
  19. Houtmeyers E., Gosselink R., Gayan-Ramirez G., Decramer M., Regulation of mucociliary clearance in health and disease, 10.1034/j.1399-3003.1999.13e39.x
  20. Rogers DF, Respir Care, 52, 1134 (2007)
  21. Lai Samuel K., Wang Ying-Ying, Hanes Justin, Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues, 10.1016/j.addr.2008.11.002
  22. Chilvers MA, Paediatr Respir Rev, 1, 27 (2000)
  23. Patton John S., Mechanisms of macromolecule absorption by the lungs, 10.1016/0169-409x(95)00113-l
  24. Pérez-Gil Jesús, Structure of pulmonary surfactant membranes and films: The role of proteins and lipid–protein interactions, 10.1016/j.bbamem.2008.05.003
  25. Wright Jo Rae, Immunoregulatory functions of surfactant proteins, 10.1038/nri1528
  26. Patton JS, Biotechnol Ther, 1, 213 (1990)
  27. Nag Kaushik, Hillier Ashley, Parsons Kyle, Garcia Mauricia Fritzen, Interactions of serum with lung surfactant extract in the bronchiolar and alveolar airway models, 10.1016/j.resp.2007.02.001
  28. Gordon S B, Read R C, Macrophage defences against respiratory tract infections, 10.1093/bmb/61.1.45
  29. Lombry C., Alveolar macrophages are a primary barrier to pulmonary absorption of macromolecules, 10.1152/ajplung.00260.2003
  30. Ducreux J, Respir Drug Deliv Eur, 1, 31 (2007)
  31. Ross HH, Romrell LJ, Kaye GI. Respiratory system, Histology - A text and atlas; Williams & Wilkins, Baltimore 1995. p. 530-57
  32. Kim CS, Folinsbee LJ. Physiological and biomechanical factors relevant to inhaled drug delivery, Inhalation delivery of therapeutic peptides and protein; M. Dekker, New York1997. p. 3-22
  33. Elbert Katharina J., Schäfer Ulrich F., Schäfers Hans‐Joachim, Kim Kwang‐Jin, Lee Vincent H. L., Lehr Claus‐Michael, 10.1023/a:1018887501927
  34. Matsukawa Yasuhisa, Lee Vincent H.L., Crandall Edward D., Kim Kwang-Jin, Size-Dependent Dextran Transport across Rat Alveolar Epithelial Cell Monolayers, 10.1021/js960352x
  35. Newman Stephen P., Chan Hak-Kim, In Vitro/In VivoComparisons in Pulmonary Drug Delivery, 10.1089/jamp.2007.0643
  36. Newman Stephen P, Wilding Ian R, Hirst Peter H, Human lung deposition data: the bridge between in vitro and clinical evaluations for inhaled drug products?, 10.1016/s0378-5173(00)00538-x
  37. Phalen Robert F., Oldham Michael J., Wolff Ronald K., The Relevance of Animal Models for Aerosol Studies, 10.1089/jamp.2007.0673
  38. Steimer Anne, Franke Helmut, Haltner-Ukomado Eleonore, Laue Michael, Ehrhardt Carsten, Lehr Claus-Michael, Monolayers of porcine alveolar epithelial cells in primary culture as an in vitro model for drug absorption studies, 10.1016/j.ejpb.2006.11.006
  39. Grainger C.I., Greenwell L.L., Martin G.P., Forbes B., The permeability of large molecular weight solutes following particle delivery to air-interfaced cells that model the respiratory mucosa, 10.1016/j.ejpb.2008.09.006
  40. Manford Fergus, Tronde Ann, Jeppsson Ann-Britt, Patel Nilesh, Johansson Fredrik, Forbes Ben, Drug permeability in 16HBE14o- airway cell layers correlates with absorption from the isolated perfused rat lung, 10.1016/j.ejps.2005.07.010
  41. Tronde Ann, Nordén B.o., Marchner Hans, Wendel Anna‐Karin, Lennernäs Hans, Bengtsson Ursula Hultkvist, Pulmonary Absorption Rate and Bioavailability of Drugs in Vivo in Rats: Structure–Absorption Relationships and Physicochemical Profiling of Inhaled Drugs, 10.1002/jps.10386
  42. Rawat Amit, Majumder Quamrul H., Ahsan Fakhrul, Inhalable large porous microspheres of low molecular weight heparin: In vitro and in vivo evaluation, 10.1016/j.jconrel.2008.03.013
  43. Lin Hongxia, Li Hong, Cho Hyun-Jong, Bian Shengjie, Roh Hwan-Jung, Lee Min-Ki, Kim Jung Sun, Chung Suk-Jae, Shim Chang-Koo, Kim Dae-Duk, Air-Liquid Interface (ALI) Culture of Human Bronchial Epithelial Cell Monolayers as an in vitro Model for Airway Drug Transport Studies, 10.1002/jps.20803
  44. Blank Fabian, Rothen-Rutishauser Barbara M., Schurch Samuel, Gehr Peter, An OptimizedIn VitroModel of the Respiratory Tract Wall to Study Particle Cell Interactions, 10.1089/jam.2006.19.392
  45. GEYS J, COENEGRACHTS L, VERCAMMEN J, ENGELBORGHS Y, NEMMAR A, NEMERY B, HOET P, In vitro study of the pulmonary translocation of nanoparticlesA preliminary study, 10.1016/j.toxlet.2005.07.005
  46. Fiegel Jennifer, 10.1023/a:1023441804464
  47. Madlova Michaela, Bosquillon Cynthia, Asker Dan, Dolezal Pavel, Forbes Ben, In-vitro respiratory drug absorption models possess nominal functional P-glycoprotein activity, 10.1211/jpp.61.03.0003
  48. Ehrhardt Carsten, Kneuer Carsten, Fiegel Jennifer, Hanes Justin, Schaefer Ulrich, Kim Kwang-Jin, Lehr Claus-Michael, Influence of apical fluid volume on the development of functional intercellular junctions in the human epithelial cell line 16HBE14o- : implications for the use of this cell line as an in vitro model for bronchial drug absorption studies, 10.1007/s00441-002-0548-5
  49. Fuchs Sabine, Hollins Andrew, Laue Michael, Schaefer Ulrich, Roemer Klaus, Gumbleton Mark, Lehr Claus-Michael, Differentiation of human alveolar epithelial cells in primary culture: morphological characterization and synthesis of caveolin-1 and surfactant protein-C, 10.1007/s00441-002-0653-5
  50. Saha Pratik, Kim Kwang-Jin, Yamahara Hiroshi, Crandall Edward D., Lee Vincent H.L., Influence of lipophilicity on β-blocker permeation across rat alveolar epithelial cell monolayers, 10.1016/0168-3659(94)90057-4
  51. Matsukawa Yasuhisa, Yamahara Hiroshi, Lee Vincent H. L., Crandall Edward D., Kim Kwang‐Jin, 10.1023/a:1016013731237
  52. Matsukawa Yasuhisa, Yamahara Hiroshi, Yamashita Fumiyoshi, Lee Vincent H.L., Crandall Edward D., Kim Kwang-Jin, Rates of Protein Transport Across Rat Alveolar Epithelial Cell Monolayers, 10.3109/10611869909085516
  53. Kim K.-J., Net absorption of IgG via FcRn-mediated transcytosis across rat alveolar epithelial cell monolayers, 10.1152/ajplung.00121.2004
  54. Dodoo Alexander N.O., Bansal Sukhrinder S., Barlow David J., Bennet Fiona, Hider Robert C., Lansley Alison B., Lawrence M.Jayne, Marriott Christopher, Use of Alveolar Cell Monolayers of Varying Electrical Resistance to Measure Pulmonary Peptide Transport, 10.1002/(sici)1520-6017(200002)89:2<223::aid-jps9>;2-r
  55. Rogers C. S., Abraham W. M., Brogden K. A., Engelhardt J. F., Fisher J. T., McCray P. B., McLennan G., Meyerholz D. K., Namati E., Ostedgaard L. S., Prather R. S., Sabater J. R., Stoltz D. A., Zabner J., Welsh M. J., The porcine lung as a potential model for cystic fibrosis, 10.1152/ajplung.90203.2008
  56. Steimer Anne, Laue Michael, Franke Helmut, Haltner-Ukomado Eleonore, Lehr Claus-Michael, Porcine Alveolar Epithelial Cells in Primary Culture: Morphological, Bioelectrical and Immunocytochemical Characterization, 10.1007/s11095-006-9057-7
  57. Grainger Christopher I., Greenwell Leona L., Lockley David J., Martin Gary P., Forbes Ben, Culture of Calu-3 Cells at the Air Interface Provides a Representative Model of the Airway Epithelial Barrier, 10.1007/s11095-006-0255-0
  58. Mathias Neil R., Timoszyk Julita, Stetsko Paul I., Megill John R., Smith Ronald L., Wall Doris A., Permeability Characteristics of Calu-3 Human Bronchial Epithelial Cells: In Vitro - In Vivo Correlation to Predict Lung Absorption in Rats, 10.1080/10611860290007504
  59. Sakagami Masahiro, In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery, 10.1016/j.addr.2006.07.012
  60. Widera Adam, Kim Kwang‐Jin J., Crandall Edward D., Shen Wei‐Chiang, 10.1023/a:1025005232421
  61. Kim Kwang-Jin, Matsukawa Yasuhisa, Yamahara Hiroshi, Kalra Vijay K., Lee Vincent H. L., Crandall Edward D., Absorption of intact albumin across rat alveolar epithelial cell monolayers, 10.1152/ajplung.00237.2002
  62. Sivadas Neeraj, O’Rourke Desmond, Tobin Aoife, Buckley Vivienne, Ramtoola Zeibun, Kelly John G., Hickey Anthony J., Cryan Sally-Ann, A comparative study of a range of polymeric microspheres as potential carriers for the inhalation of proteins, 10.1016/j.ijpharm.2008.03.024
  63. Matilainen Laura, Toropainen Tarja, Vihola Henna, Hirvonen Jouni, Järvinen Tomi, Jarho Pekka, Järvinen Kristiina, In vitro toxicity and permeation of cyclodextrins in Calu-3 cells, 10.1016/j.jconrel.2007.11.003
  64. Blank Fabian, Rothen-Rutishauser Barbara, Gehr Peter, Dendritic Cells and Macrophages Form a Transepithelial Network against Foreign Particulate Antigens, 10.1165/rcmb.2006-0234oc
  65. Sakagami Masahiro, Byron Peter R., Venitz Jurgen, Rypacek Frantisek, Solute disposition in the rat lung in vivo and in vitro: Determining regional absorption kinetics in the presence of mucociliary escalator, 10.1002/jps.10069
  66. Niven Ralph W., Byron Peter R., 10.1023/a:1015942013413
  67. Tronde Ann, Krondahl Eva, von Euler-Chelpin Hans, Brunmark Per, Hultkvist Bengtsson Ursula, Ekström Gunilla, Lennernäs Hans, High airway-to-blood transport of an opioid tetrapeptide in the isolated rat lung after aerosol delivery, 10.1016/s0196-9781(01)00624-6
  68. Niemeier R W, The isolated perfused lung, 10.1289/ehp.845635
  69. Uhlig Stefan, Heiny Ottmar, Measuring the weight of the isolated perfused rat lung during negative pressure ventilation, 10.1016/1056-8719(94)00069-g
  70. Jesús Valle María José de, González López Francisco, Sánchez Navarro Amparo, Pulmonary versus systemic delivery of levofloxacin, 10.1016/j.pupt.2007.07.003
  71. Saumon G, Am J Physiol, 269, L185 (1995)
  72. Ewing Per, Eirefelt Stefan J., Andersson Paul, Blomgren Anders, Ryrfeldt Åke, Gerde Per, Short Inhalation Exposures of the Isolated and Perfused Rat Lung to Respirable Dry Particle Aerosols; the Detailed Pharmacokinetics of Budesonide, Formoterol, and Terbutaline, 10.1089/jamp.2007.0654
  73. Pang Yinuo, Sakagami Masahiro, Byron Peter R., The pharmacokinetics of pulmonary insulin in the in vitro isolated perfused rat lung: Implications of metabolism and regional deposition, 10.1016/j.ejps.2005.03.010
  74. Tronde Ann, Nordén Bo, Jeppsson Ann-Britt, Brunmark Per, Nilsson† Elisabeth, Lennernäs Hans, Bengtsson Ursula Hultkvist, Drug Absorption from the Isolated Perfused Rat Lung–Correlations with Drug Physicochemical Properties and Epithelial Permeability, 10.1080/1061186031000086117
  75. Koshkina NV, Clin Cancer Res, 7, 3258 (2001)
  76. Myrdal P.B., Karlage K., Kuehl P.J., Angersbach B.S., Merrill B.A., Wightman P.D., Effects of novel 5-lipoxygenase inhibitors on the incidence of pulmonary adenomas in the A/J murine model when administered via nose-only inhalation, 10.1093/carcin/bgl216
  77. Tam Jasmine M., McConville Jason T., Williams Robert O., Johnston Keith P., Amorphous cyclosporin nanodispersions for enhanced pulmonary deposition and dissolution, 10.1002/jps.21367
  78. SINSWAT P, OVERHOFF K, MCCONVILLE J, JOHNSTON K, WILLIAMSIII R, Nebulization of nanoparticulate amorphous or crystalline tacrolimus – Single-dose pharmacokinetics study in mice, 10.1016/j.ejpb.2008.01.037
  79. Muttil Pavan, Kaur Jatinder, Kumar Kaushlendra, Yadav Awadh Bihari, Sharma Rolee, Misra Amit, Inhalable microparticles containing large payload of anti-tuberculosis drugs, 10.1016/j.ejps.2007.06.006
  80. Onischuk AA, J Aerosol Med Pulm Drug Deliv (2009)
  81. Onischuk Andrei A., Tolstikova Tatjana G., Sorokina Irina V., Zhukova Natalja A., Baklanov Anatoly M., Karasev Vladimir V., Dultseva Galina G., Boldyrev Vladimir V., Fomin Vasilii M., Anti-inflammatory Effect from Indomethacin Nanoparticles Inhaled by Male Mice, 10.1089/jamp.2007.0672
  82. Manford Fergus, Riffo-Vasquez Yanira, Spina Domenico, Page Clive P., Hutt Andrew J., Moore Vanessa, Johansson Fredrik, Forbes Ben, Lack of difference in pulmonary absorption of digoxin, a P-glycoprotein substrate, inmdr1a-deficient andmdr1a-competent mice, 10.1211/jpp.60.10.0006
  83. Choi W. S., Murthy G. G. K., Edwards D. A., Langer R., Klibanov A. M., Inhalation delivery of proteins from ethanol suspensions, 10.1073/pnas.201413798
  84. Bartus R. T., A Pulmonary Formulation of L-Dopa Enhances Its Effectiveness in a Rat Model of Parkinson's Disease, 10.1124/jpet.103.064121
  85. Jalalipour Monireh, Najafabadi Abdolhossien Rouholamini, Gilani Kambiz, Esmaily Hadi, Tajerzadeh Hosnieh, Effect of dimethyl‐β‐cyclodextrin concentrations on the pulmonary delivery of recombinant human growth hormone dry powder in rats, 10.1002/jps.21353
  86. Ricciardolo Fabio, Nijkamp Frans, Rose Virginia, Folkerts Gert, The Guinea Pig as an Animal Model for Asthma, 10.2174/138945008784533534
  87. Padilla-Carlin DJ, Comp Med, 58, 324 (2008)
  88. Garcia-Contreras L., Fiegel J., Telko M. J., Elbert K., Hawi A., Thomas M., VerBerkmoes J., Germishuizen W. A., Fourie P. B., Hickey A. J., Edwards D., Inhaled Large Porous Particles of Capreomycin for Treatment of Tuberculosis in a Guinea Pig Model, 10.1128/aac.01164-06
  89. Jansen Mendel, Darby Ian, Abribat Thierry, Dubreuil Pascal, Ferdinandi Eckhardt S, Hardy John G, Pulmonary delivery of TH9507, a growth hormone releasing factor analogue, in the dog, 10.1016/j.ijpharm.2004.02.012
  90. Rabinowitz Joshua D., Lloyd Peter M., Munzar Patrik, Myers Daniel J., Cross Steve, Damani Ramesh, Quintana Reynaldo, Spyker Daniel A., Soni Pravin, Cassella James V., Ultra-Fast Absorption of Amorphous Pure Drug Aerosols via Deep Lung Inhalation, 10.1002/jps.20694
  91. Vick Andrew, Wolff Ronald, Koester Alan, Reams Rachel, Deaver Daniel R., Heidel Shawn, A 6-Month Inhalation Study to Characterize the Toxicity, Pharmacokinetics, and Pharmacodynamics of Human Insulin Inhalation Powder (HIIP) in Beagle Dogs, 10.1089/jam.2007.0586
  92. Bjertnaes Lars J., McGuire Roy, Jodoin Jeffery, Salzman Andrew L., Traber Lillian D., Passerini Daniel J., Smith Daniel J., Szabo Csaba, Traber Daniel L., Nebulized nitric oxide/nucleophile adduct reduces pulmonary vascular resistance in mechanically ventilated septicemic sheep* : , 10.1097/01.ccm.0000156282.22495.a1
  93. Sandifer Brett L., Brigham Kenneth L., Lawrence E.Clinton, Parker Richard E., Effects of Aerosol vs IV UT-15 on Prostaglandin H2 Analog-Induced Pulmonary Hypertension in Sheep, 10.1378/chest.128.6_suppl.616s-a
  94. Harkema Jack R., Carey Stephan A., Wagner James G., The Nose Revisited: A Brief Review of the Comparative Structure, Function, and Toxicologic Pathology of the Nasal Epithelium, 10.1080/01926230600713475
  95. Hofmann W., The Effect of Lung Structure on Mucociliary Clearance and Particle Retention in Human and Rat Lungs, 10.1093/toxsci/kfg075
  96. Stone Kimberly C., Mercer Robert R., Gehr Peter, Stockstill Barbara, Crapo James D., Allometric Relationships of Cell Numbers and Size in the Mammalian Lung, 10.1165/ajrcmb/6.2.235
  97. Alvarez Carlos A., Wiederhold Nathan P., McConville Jason T., Peters Jay I., Najvar Laura K., Graybill John R., Coalson Jacqueline J., Talbert Robert L., Burgess David S., Bocanegra Rosie, Johnston Keith P., Williams Robert O., Aerosolized nanostructured itraconazole as prophylaxis against invasive pulmonary aspergillosis, 10.1016/j.jinf.2007.01.014
  98. Sharma Rolee, Saxena Deepali, Dwivedi Anil K., Misra Amit, 10.1023/a:1012296604685
  99. Zijlstra G.S., Brandsma C.A., Harpe M.F.H., Van Dam G.M., Slebos D.J., Kerstjens H.A.M., De Boer A.H., Frijlink H.W., Dry powder inhalation of hemin to induce heme oxygenase expression in the lung, 10.1016/j.ejpb.2007.03.021
  100. Nadithe Venkatareddy, Rahamatalla Muhib, Finlay Warren H., Mercer John R., Samuel John, Evaluation of nose-only aerosol inhalation chamber and comparison of experimental results with mathematical simulation of aerosol deposition in mouse lungs, 10.1002/jps.10379
  101. Martin Andrew R., Thompson Richard B., Finlay Warren H., MRI Measurement of Regional Lung Deposition in Mice Exposed Nose-Only to Nebulized Superparamagnetic Iron Oxide Nanoparticles, 10.1089/jamp.2008.0698
  102. Tseng Ching-Li, Wu Steven Yueh-Hsiu, Wang Wen-Hsi, Peng Cheng-Liang, Lin Feng-Huei, Lin Chien-Cheng, Young Tai-Horng, Shieh Ming-Jium, Targeting efficiency and biodistribution of biotinylated-EGF-conjugated gelatin nanoparticles administered via aerosol delivery in nude mice with lung cancer, 10.1016/j.biomaterials.2008.03.033
  103. Gautam Ajay, Densmore Charles L., Waldrep J.Clifford, Inhibition of Experimental Lung Metastasis by Aerosol Delivery of PEI–p53 Complexes, 10.1006/mthe.2000.0138
  104. Rozlog Leigh A., Kiecolt-Glaser Janice K., Marucha Phillip T., Sheridan John F., Glaser Ronald, Stress and Immunity: Implications for Viral Disease and Wound Healing, 10.1902/jop.1999.70.7.786
  105. Jacob ST, Gene Expr, 7, 301 (1999)
  106. Pauluhn Jürgen, Thiel Achim, A simple approach to validation of directed-flow nose-only inhalation chambers, 10.1002/jat.1188
  107. Verma R. K., Kaur J., Kumar K., Yadav A. B., Misra A., Intracellular Time Course, Pharmacokinetics, and Biodistribution of Isoniazid and Rifabutin following Pulmonary Delivery of Inhalable Microparticles to Mice, 10.1128/aac.00153-08
  108. Lombry Catherine, Marteleur Aline, Arras Mohammed, Lison Dominique, Louahed Jamila, Renauld Jean-Christophe, Préat Véronique, Vanbever Rita, Local and Systemic Immune Responses to Intratracheal Instillation of Antigen and DNA Vaccines in Mice, 10.1023/b:pham.0000012160.00222.55
  109. Deshpande Deepa S., Blanchard James D., Schuster Jeffrey, Fairbanks Dallas, Hobbs Charles, Beihn Robert, Densmore Charles, Farr Stephen, Gonda Igor, Gamma Scintigraphic Evaluation of a Miniaturized AERx® Pulmonary Delivery System for Aerosol Delivery to Anesthetized Animals Using a Positive Pressure Ventilation System, 10.1089/jam.2005.18.34
  110. Rich Preston B, Douillet Christelle D, Hurd Harry, Boucher Richard C, Effect of ventilatory rate on airway cytokine levels and lung injury, 10.1016/s0022-4804(03)00195-1
  111. Minne A., Jaworska J., Gerhold K., Ahrens B., Avagyan A., Vanbever R., Matricardi P. M., Schmidt A. C., Hamelmann E., Intranasal delivery of whole influenza vaccine prevents subsequent allergen-induced sensitization and airway hyper-reactivity in mice, 10.1111/j.1365-2222.2007.02767.x
  112. Courrier H.M., Pons F., Lessinger J.M., Frossard N., Krafft M.P., Vandamme Th.F., In vivo evaluation of a reverse water-in-fluorocarbon emulsion stabilized with a semifluorinated amphiphile as a drug delivery system through the pulmonary route, 10.1016/j.ijpharm.2004.06.011
  113. Massaro D., Noninvasive delivery of small inhibitory RNA and other reagents to pulmonary alveoli in mice, 10.1152/ajplung.00067.2004
  114. Bolognin M., Kirschvink N., Leemans J., De Buscher V., Snaps F., Gustin P., Peeters D., Clercx C., Characterisation of the acute and reversible airway inflammation induced by cadmium chloride inhalation in healthy dogs and evaluation of the effects of salbutamol and prednisolone, 10.1016/j.tvjl.2007.10.004
  115. Youn Yu Seok, Kwon Min Jung, Na Dong Hee, Chae Su Young, Lee Seulki, Lee Kang Choon, Improved intrapulmonary delivery of site-specific PEGylated salmon calcitonin: Optimization by PEG size selection, 10.1016/j.jconrel.2007.10.008
  116. Codrons Valérie, Vanderbist Francis, Verbeeck Roger K., Arras Mohammed, Lison Dominique, Préat Véronique, Vanbever Rita, Systemic delivery of parathyroid hormone (1-34) using inhalation dry powders in rats, 10.1002/jps.10346
  117. Chatziioannou A. F., Instrumentation for Molecular Imaging in Preclinical Research: Micro-PET and Micro-SPECT, 10.1513/pats.200508-079ds
  118. FOK TAI F., AL-ESSA MAZAN, KIRPALANI HARESH, MONKMAN SHELLY, BOWEN BARRY, COATES GEOFFREY, DOLOVICH MYRNA, Estimation of Pulmonary Deposition of Aerosol Using Gamma Scintigraphy, 10.1089/jam.1999.12.9
  119. Martorana Piero A., Cavarra Eleonora, Lucattelli Monica, Lungarella Giuseppe, Models for COPD involving cigarette smoke, 10.1016/j.ddmod.2006.09.004
  120. Matute-Bello G., Frevert C. W., Martin T. R., Animal models of acute lung injury, 10.1152/ajplung.00010.2008
  121. Zosky G. R., Sly P. D., Animal models of asthma, 10.1111/j.1365-2222.2007.02740.x
  122. Ehrhardt Carsten, Collnot Eva-Maria, Baldes Christiane, Becker Ulrich, Laue Michael, Kim Kwang-Jin, Lehr Claus-Michael, Towards an in vitro model of cystic fibrosis small airway epithelium: characterisation of the human bronchial epithelial cell line CFBE41o-, 10.1007/s00441-005-0062-7
  123. Wall Doris A., Pulmonary Absorption of Peptides and Proteins, 10.3109/10717549509031346
  124. Derelanko MJ, Hollinger MA. Handbook of toxicology, CRC Press, Boca Raton 2002.
  125. Rennard SI, J Appl Physiol, 60, 532 (1986)
  126. BAYAT SAM, MENAOUAR AHMED, ANGLADE DANIEL, ETTINGER HENRY, FRANÇOIS-JOUBERT ANNE, BENCHETRIT GILA, GRIMBERT FRANCIS A., In VivoQuantitation of Epithelial Lining Fluid in Dog Lung, 10.1164/ajrccm.158.6.9803016
  127. Ghofrani HA, Am J Physiol Lung Cell Mol Physiol, 280, L896 (2001)
  128. Icard P, Am J Physiol, 277, L1232 (1999)
  129. Kimoto Takahiro, Takanashi Masashi, Mukai Hironori, Ogawara Ken-ichi, Kimura Toshikiro, Higaki Kazutaka, Effect of adrenergic stimulation on drug absorption via passive diffusion in Caco-2 cells, 10.1016/j.ijpharm.2008.09.050
  130. Rothen-Rutishauser Barbara M., Kiama Stephen G., Gehr Peter, A Three-Dimensional Cellular Model of the Human Respiratory Tract to Study the Interaction with Particles, 10.1165/rcmb.2004-0187oc
  131. Davies Brian, Morris Tim, 10.1023/a:1018943613122
  132. Lai Y-L. Comparative ventilation of the normal lung. In: Parent RA, editors, Treatise on pulmonary toxicology - comparative biology of the normal lung; Parent RA editors, Boca Raton, FL. 1992. p. 217-39
  133. Asgharian B., Respiratory Deposition and Inhalability of Monodisperse Aerosols in Long-Evans Rats, 10.1093/toxsci/71.1.104
Bibliographic reference Fernandes, Cláudia A. ; Vanbever, Rita. Preclinical models for pulmonary drug delivery. In: Expert Opinion on Drug Delivery, Vol. 6, no. 11, p. 1231-1245 (2009)
Permanent URL