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Unconventional roles of lactate along the tumor and immune landscape.

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Ippolito, Luigi Sonveaux, Pierre [UCL] Chiarugi, Paola

The tumor ecosystem evolves with dynamic interactions between cancer and normal cells, and nutrients have emerged as new regulators of cancer hallmarks. Lactate has climbed the rankings as a multifunctional molecule orchestrating many aspects of the disease onset and progression. Here, we patchwork and discuss the main recent findings conferred during the EMBO workshop titled 'Lactate: Unconventional Roles of a Nutrient Along the Tumor Landscape.'

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès mixte
Publication date 2022
Language Anglais
Journal information "Trends in endocrinology and metabolism" - Vol. 33, no.4, p. 231-235 (2022)
Peer reviewed yes
Publisher Elsevier Science Pub. Co. ((United States) New York, NY)
issn 1043-2760
e-issn 1879-3061
Publication status Publié
Affiliation UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique
MESH Subject Ecosystem ; Humans ; Lactic Acid ; Neoplasms
Keywords immunomodulation ; lactate ; monocarboxylate transporters (MCTs) ; tumor metabolism ; tumor microenvironment
Links
Bibliographic reference Ippolito, Luigi ; Sonveaux, Pierre ; Chiarugi, Paola. Unconventional roles of lactate along the tumor and immune landscape.. In: Trends in endocrinology and metabolism, Vol. 33, no.4, p. 231-235 (2022)
Permanent URL http://hdl.handle.net/2078.1/280416