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Outbreak of infection by carbapenem-resistant Acinetobacter baumannii producing the carbapenemase OXA-58 in Belgium.

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Bogaerts, Pierre Naas, Thierry Wybo, Ingrid Bauraing, Caroline Soetens, Oriane Glupczynski, Gerald [UCL]

Carbapenem-resistant Acinetobacter baumannii isolates were obtained from 17 patients between September 2004 and August 2005 at the Academisch Ziekenhuis Vrije Universiteit Brussel, Brussels, Belgium. These multidrug-resistant isolates, which belonged to a single clone, remained susceptible to colistin and tigecycline only and produced the carbapenem-hydrolyzing oxacillinase OXA-58. This study highlights the importance of the intercountry spread of this beta-lactamase-mediated resistance mechanism and its epidemic evolution.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès libre
Publication date 2006
Journal information "Journal of clinical microbiology" - Vol. 44, no. 11, p. 4189-92 (2006)
Peer reviewed yes
issn 0095-1137
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Acinetobacter Infections - epidemiology ; Acinetobacter baumannii - drug effects - enzymology - genetics ; Adult ; Aged ; Belgium - epidemiology ; Carbapenems - pharmacology ; Disease Outbreaks ; Drug Resistance, Bacterial ; Female ; Humans ; Male ; Microbial Sensitivity Tests ; Middle Aged ; beta-Lactamases - biosynthesis
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Bibliographic reference Bogaerts, Pierre ; Naas, Thierry ; Wybo, Ingrid ; Bauraing, Caroline ; Soetens, Oriane ; et. al. Outbreak of infection by carbapenem-resistant Acinetobacter baumannii producing the carbapenemase OXA-58 in Belgium.. In: Journal of clinical microbiology, Vol. 44, no. 11, p. 4189-92 (2006)
Permanent URL http://hdl.handle.net/2078.1/27394