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Progressive tubulointerstitial nephropathy with hepatic involvement in an infant.

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Henrot, B. Vermylen, Christiane [UCL] Caus, D Cosyns, Jean-Pierre [UCL] Gosseye, Serge [UCL] Verellen, Gaston [UCL] Cornu, Guy [UCL]

We describe an infant with renal and liver disease who died at the age of 10 months from chronic renal failure. Hepatosplenomegaly was present along with biochemical findings of cholestasis and cytolysis. The diagnosis of tubulointerstitial nephropathy with cortical microcysts associated with hepatic fibrosis was based upon laboratory, radiological, and histological data. This rarely described disorder is characterized by an early clinical onset and unfavourable progression to end-stage renal failure before the age of 2.

Document type Article de périodique (Journal article) – Case Reports, Journal Article, Review
Access type Accès restreint
Publication date 1990
Journal information "European journal of pediatrics" - Vol. 149, no. 5, p. 365-7 (1990)
Peer reviewed yes
issn 0340-6199
Publication status Publié
Affiliation UCL - MD/MNOP - Département de morphologie normale et pathologique
MESH Subject Humans ; Infant ; Kidney - abnormalities - pathology ; Kidney Failure, Chronic - complications ; Liver - pathology ; Liver Cirrhosis - complications ; Male ; Nephritis, Interstitial - complications
Links
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Bibliographic reference Henrot, B. ; Vermylen, Christiane ; Caus, D ; Cosyns, Jean-Pierre ; Gosseye, Serge ; et. al. Progressive tubulointerstitial nephropathy with hepatic involvement in an infant.. In: European journal of pediatrics, Vol. 149, no. 5, p. 365-7 (1990)
Permanent URL http://hdl.handle.net/2078.1/26410