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Antacid-induced osteomalacia.

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Boutsen, Yves [UCL] Devogelaer, Jean-Pierre [UCL] Malghem, Jacques [UCL] Noël, Henri [UCL] Nagant de Deuxchaisnes, C

The case of a 49-year-old woman suffering from generalized skeletal pain and multiple fractures accompanied by severe hypophosphataemia and low urinary phosphorus excretion is reported. She had been taking large amounts of antacids containing aluminum hydroxide for many years. A diagnosis of antacid-induced osteomalacia was made. It was confirmed by biological work-up, radiographs and bone biopsy. A dramatic biological, osteodensitometric, and clinical improvement was achieved by withdrawal of antacids and phosphorus administration. The literature concerning this unusual condition has been reviewed.

Document type Article de périodique (Journal article) – Case Reports, Journal Article, Review
Access type Accès restreint
Publication date 1996
Journal information "Clinical rheumatology" - Vol. 15, no. 1, p. 75-80 (1996)
Peer reviewed yes
issn 0770-3198
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - MD/RAIM - Département de radiologie et d'imagerie médicale
MESH Subject Adult ; Aged ; Antacids - adverse effects - therapeutic use ; Biopsy, Needle ; Bone Density ; Female ; Heartburn - drug therapy ; Humans ; Hypophosphatemia - chemically induced ; Male ; Middle Aged ; Osteomalacia - chemically induced - diagnosis - physiopathology - therapy ; Phosphorus - administration & dosage - therapeutic use ; Tomography, X-Ray Computed
Links
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Bibliographic reference Boutsen, Yves ; Devogelaer, Jean-Pierre ; Malghem, Jacques ; Noël, Henri ; Nagant de Deuxchaisnes, C. Antacid-induced osteomalacia.. In: Clinical rheumatology, Vol. 15, no. 1, p. 75-80 (1996)
Permanent URL http://hdl.handle.net/2078.1/26371