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In vitro immunosuppressive activity of tacrolimus dihydrodiol precursors obtained by chemical oxidation and identification of a new metabolite of SDZ-RAD by electrospray and electrospray-linked scan mass spectrometry.

Bibliographic reference Lhoëst, Georges ; Hertsens, R ; Verbeeck, Roger-K. ; Maton, Nicole ; Wallemacq, Pierre ; et. al. In vitro immunosuppressive activity of tacrolimus dihydrodiol precursors obtained by chemical oxidation and identification of a new metabolite of SDZ-RAD by electrospray and electrospray-linked scan mass spectrometry.. In: Journal of mass spectrometry : JMS, Vol. 36, no. 8, p. 889-901 (2001)
Permanent URL http://hdl.handle.net/2078.1/26226
  1. Goto, Transplant. Proc., 19, 4 (1987)
  2. Peters David H., Fitton Andrew, Plosker Greg L., Faulds Diana, Tacrolimus : A Review of its Pharmacology, and Therapeutic Potential in Hepatic and Renal Transplantation, 10.2165/00003495-199346040-00009
  3. Hooks Michael A., Tacrolimus, a New Immunosuppressant—A Review of the Literature, 10.1177/106002809402800414
  4. Hong, Semin-Nephrol., 20, 108 (2000)
  5. Shimizu, Clin-Transplant., 13, 48 (1999)
  6. Kumano, Transplant. Proc., 23, 512 (1991)
  7. Tanaka Hirokazu, Kuroda Akio, Marusawa Hiroshi, Hatanaka Hiroshi, Kino Toru, Goto Toshio, Hashimoto Masashi, Taga Toru, Structure of FK506, a novel immunosuppressant isolated from Streptomyces, 10.1021/ja00250a050
  8. Taga T., Tanaka H., Goto T., Tada S., Structure of a new macrocyclic antibiotic, 10.1107/s0108270187094253
  9. Vincent Styliani H., Karanam Bindhu V., Painter Susan K., Chiu Shuet-Hing L., In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: Identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism, 10.1016/0003-9861(92)90711-5
  10. Iwasaki, Drug Metab. Disp., 21, 971 (1993)
  11. Lhoëst, J. Pharmacol. Exp. Ther., 274, 622 (1995)
  12. Lhoest G., Maton N., Laurent A., Verbeeck R.K., Isolation and identification of a FK-506 C36–C37 dihydrodiol from erythromycin-induced rabbit liver microsomes, 10.1016/0731-7085(94)90034-5
  13. Lhoëst, J. Pharmacol. Exp. Ther., 284, 1074 (1998)
  14. Calne R.Y., Lim Susan, Samaan A., Collier D.ST.J., Pollard S.G., White D.J.G., Thiru Sathia, RAPAMYCIN FOR IMMUNOSUPPRESSION IN ORGAN ALLOGRAFTING, 10.1016/s0140-6736(89)90417-0
  15. Sedrani R, Cottens S, Kallen J, Schuler W, Chemical modification of rapamycin: the discovery of SDZ RAD, 10.1016/s0041-1345(98)00587-9
  16. Morris Randall Ellis, Rapamycins: Antifungal, antitumor, antiproliferative, and immunosuppressive macrolides, 10.1016/s0955-470x(10)80014-x
  17. Sattler, Drug Metab. Dispos., 20, 753 (1992)
  18. Dannecker R, Vickers A.E.M, Ubeaud G, Hauck Ch, In vitro biotransformation of SDZ RAD: a new immunosuppressive macrolide in human liver microsomal preparations, 10.1016/s0041-1345(98)00592-2
  19. Lhoëst, J. Mass Spectrom., 34, 28 (1999)
  20. NICKMILDER M. J. M., LATINNE D., VERBEECK R. K., JANSSENS W., SVOBODA D., LHOEST* G. J. J., Isolation and identification of new rapamycin dihydrodiol metabolites from dexamethasoneinduced rat liver microsomes, 10.1080/004982597240055
  21. Lho�st G. J. J., Gougnard T. Y. R., Verbeeck R. K., Maton N., Dehoux J. P., Wallemacq P., Sch�ler W., Latinne D., Isolation from pig liver microsomes, identification by tandem mass spectrometry andin vitro immunosuppressive activity of an SDZ-RAD 17,18,19,20,21,22-tris-epoxide, 10.1002/(sici)1096-9888(200003)35:3<454::aid-jms959>3.0.co;2-k
  22. Kon G. A. R., Linstead R. P., Wright J. M., 125. Investigations of the olefinic acids. Part XII. β-Phenylhexenoic and β-methylpentenoic acids, 10.1039/jr9340000599
  23. Amar-Costesec A., ANALYTICAL STUDY OF MICROSOMES AND ISOLATED SUBCELLULAR MEMBRANES FROM RAT LIVER: II. Preparation and Composition of the Microsomal Fraction, 10.1083/jcb.61.1.201
  24. Lowry, J. Biol. Chem., 193, 265 (1951)
  25. Omura, J. Biol. Chem., 239, 2370 (1964)
  26. Lhoëst, Mass Spectrometry in Cancer Research, 164 (1994)
  27. KAY John E., Structure-function relationships in the FK506-binding protein (FKBP) family of peptidylprolylcis-transisomerases, 10.1042/bj3140361