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Regulation of protein kinase D by multisite phosphorylation. Identification of phosphorylation sites by mass spectrometry and characterization by site-directed mutagenesis.

Bibliographic reference Vertommen, Didier ; Rider, Mark ; Ni, Yicheng ; Waelkens, E. ; Merlevede, W ; et. al. Regulation of protein kinase D by multisite phosphorylation. Identification of phosphorylation sites by mass spectrometry and characterization by site-directed mutagenesis.. In: The Journal of biological chemistry, Vol. 275, no. 26, p. 19567-76 (2000)
Permanent URL http://hdl.handle.net/2078.1/26115
  1. Valverde A. M., Sinnett-Smith J., Van Lint J., Rozengurt E., Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain., 10.1073/pnas.91.18.8572
  2. Van Lint Johan, Sinnett-Smith James, Rozengurt Enrique, Expression and Characterization of PKD, a Phorbol Ester and Diacylglycerol-stimulated Serine Protein Kinase, 10.1074/jbc.270.3.1455
  3. Zugaza, EMBO J., 15, 6220 (1996)
  4. Matthews Sharon A., Pettit George R., Rozengurt Enrique, Bryostatin 1 Induces Biphasic Activation of Protein Kinase D in Intact Cells, 10.1074/jbc.272.32.20245
  5. Zugaza José L., Waldron Richard T., Sinnett-Smith James, Rozengurt Enrique, Bombesin, Vasopressin, Endothelin, Bradykinin, and Platelet-derived Growth Factor Rapidly Activate Protein Kinase D through a Protein Kinase C-dependent Signal Transduction Pathway, 10.1074/jbc.272.38.23952
  6. Abedi Husna, Rozengurt Enrique, Zachary Ian, Rapid activation of the novel serine/threonine protein kinase, protein kinase D by phorbol esters, angiotensin II and PDGF-BB in vascular smooth muscle cells, 10.1016/s0014-5793(98)00427-x
  7. Van Lint Johan, Ni Youping, Valius Mindaugas, Merlevede Wilfried, Vandenheede Jackie R., Platelet-derived Growth Factor Stimulates Protein Kinase D through the Activation of Phospholipase Cγ and Protein Kinase C, 10.1074/jbc.273.12.7038
  8. Johannes Franz-Josef, Horn Judith, Link Gisela, Haas Elvira, Siemienski Katrin, Wajant Harald, Pfizenmaier Klaus, Protein kinase Cmu downregulation of tumor-necrosis-factor-induced apoptosis correlates with enhanced expression of nuclear-factor-kappaB-dependent protective genes, 10.1046/j.1432-1327.1998.2570047.x
  9. Jamora Colin, Yamanouye Norma, Van Lint Johan, Laudenslager John, Vandenheede Jackie R., Faulkner D.John, Malhotra Vivek, Gβγ-Mediated Regulation of Golgi Organization Is through the Direct Activation of Protein Kinase D, 10.1016/s0092-8674(00)80606-6
  10. Bowden Emma T, Barth Mara, Thomas Dianne, Glazer Robert I, Mueller Susette C, An invasion-related complex of cortactin, paxillin and PKCμ associates with invadopodia at sites of extracellular matrix degradation, 10.1038/sj.onc.1202827
  11. Rennecke J�rg, Rehberger Petra Andrea, F�rstenberger Gerhard, Johannes Franz-Josef, St�hr Michael, Marks Friedrich, Richter Karl Hartmut, Protein-kinase-C? expression correlates with enhanced keratinocyte proliferation in normal and neoplastic mouse epidermis and in cell culture, 10.1002/(sici)1097-0215(19990105)80:1<98::aid-ijc19>3.0.co;2-d
  12. Dieterich Sabine, Herget Thomas, Link Gisela, Böttinger Heiner, Pfizenmaier Klaus, Johannes Franz-Josef, In vitro activation and substrates of recombinant, baculovirus expressed human protein kinase Cμ, 10.1016/0014-5793(96)00116-0
  13. Johannes, J. Biol. Chem., 269, 6140 (1994)
  14. Rozengurt E., Sinnett-Smith J., Zugaza J. L., Protein kinase D: a novel target for diacylglycerol and phorbol esters, 10.1042/bst0250565
  15. Waldron Richard T., Iglesias Teresa, Rozengurt Enrique, The Pleckstrin Homology Domain of Protein Kinase D Interacts Preferentially with the η Isoform of Protein Kinase C, 10.1074/jbc.274.14.9224
  16. Iglesias Teresa, Waldron Richard T., Rozengurt Enrique, Identification ofin VivoPhosphorylation Sites Required for Protein Kinase D Activation, 10.1074/jbc.273.42.27662
  17. Matthews Sharon A., Rozengurt Enrique, Cantrell Doreen, Characterization of Serine 916 as anin VivoAutophosphorylation Site for Protein Kinase D/Protein Kinase Cμ, 10.1074/jbc.274.37.26543
  18. Alessi Dario R., Barry Caudwell F., Andjelkovic Mirjana, Hemmings Brian A., Cohen Philip, Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase, 10.1016/s0014-5793(96)01370-1
  19. Bradford Marion M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, 10.1016/0003-2697(76)90527-3
  20. Allen G. (1989) in Sequencing of Proteins and Peptides, eds Work T. S. Burdon R. H. (Elsevier Science Publishers B.V. Amsterdam), pp 140–141.
  21. LAEMMLI U. K., Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4, 10.1038/227680a0
  22. Matthews Sharon, Iglesias Teresa, Cantrell Doreen, Rozengurt Enrique, Dynamic re-distribution of protein kinase D (PKD) as revealed by a GFP-PKD fusion protein: dissociation from PKD activation, 10.1016/s0014-5793(99)01090-x
  23. Iglesias Teresa, Rozengurt Enrique, Protein Kinase D Activation by Mutations within Its Pleckstrin Homology Domain, 10.1074/jbc.273.1.410
  24. Tan, J. Biol. Chem., 265, 13818 (1990)
  25. DeGnore Jon P., Qin Jun, Fragmentation of phosphopeptides in an ion trap mass spectrometer, 10.1016/s1044-0305(98)00088-9
  26. Bornancin Frédéric, Parker Peter J., Phosphorylation of Protein Kinase C-α on Serine 657 Controls the Accumulation of Active Enzyme and Contributes to Its Phosphatase-resistant State, 10.1074/jbc.272.6.3544
  27. Edwards Amelia S., Newton Alexandra C., Phosphorylation at Conserved Carboxyl-terminal Hydrophobic Motif Regulates the Catalytic and Regulatory Domains of Protein Kinase C, 10.1074/jbc.272.29.18382
  28. Newton, J. Biol. Chem., 264, 14909 (1989)
  29. Newton A C, Interaction of Proteins With Lipid Headgroups: Lessons from Protein Kinase C, 10.1146/annurev.bb.22.060193.000245
  30. Johannes Franz-Josef, Prestle Jurgen, Dieterich Sabine, Oberhagemann Petra, Link Gisela, Pfizenmaier Klaus, Characterization of Activators and Inhibitors of Protein Kinase Cmu, 10.1111/j.1432-1033.1995.tb20389.x
  31. Behn-Krappa Annett, Newton Alexander C., The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation, 10.1016/s0960-9822(99)80332-7
  32. Inoue, J. Biol. Chem., 252, 7610 (1977)
  33. Parker P. J. Dekker L. V. (1997) Protein Kinase C (R. G. Landes Company, Georgetown, TX).
  34. Cardone Michael H, Salvesen Guy S, Widmann Christian, Johnson Gary, Frisch Steven M, The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases, 10.1016/s0092-8674(00)80339-6
  35. Nishikawa Kiyotaka, Toker Alex, Johannes Franz-Josef, Songyang Zhou, Cantley Lewis C., Determination of the Specific Substrate Sequence Motifs of Protein Kinase C Isozymes, 10.1074/jbc.272.2.952
  36. Lee N., MacDonald H., Reinhard C., Halenbeck R., Roulston A., Shi T., Williams L. T., Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis, 10.1073/pnas.94.25.13642
  37. Emoto, EMBO J., 14, 6148 (1995)
  38. Takahashi M., Mukai H., Toshimori M., Miyamoto M., Ono Y., Proteolytic activation of PKN by caspase-3 or related protease during apoptosis, 10.1073/pnas.95.20.11566
  39. Alessi Dario R., James Stephen R., Downes C.Peter, Holmes Andrew B., Gaffney Piers R.J., Reese Colin B., Cohen Philip, Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα, 10.1016/s0960-9822(06)00122-9
  40. Pullen N., Phosphorylation and Activation of p70s6k by PDK1, 10.1126/science.279.5351.707
  41. Yonemoto W., McGlone M. L., Grant B., Taylor S. S., Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli, 10.1093/protein/10.8.915
  42. Peterson Randall T., Schreiber Stuart L., Kinase phosphorylation: Keeping it all in the family, 10.1016/s0960-9822(99)80326-1
  43. Meier R., Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha ) promoted by hyperosmotic stress, 10.1093/emboj/17.24.7294
  44. Delhase M., Positive and Negative Regulation of IB Kinase Activity Through IKK Subunit Phosphorylation, 10.1126/science.284.5412.309
  45. Hanks, FASEB J., 9, 576 (1995)
  46. Hausser Angelika, Storz Peter, Link Gisela, Stoll Hartmut, Liu Yun-Cai, Altman Amnon, Pfizenmaier Klaus, Johannes Franz-Josef, Protein Kinase C μ Is Negatively Regulated by 14-3-3 Signal Transduction Proteins, 10.1074/jbc.274.14.9258
  47. Ben-Levy, EMBO J., 14, 5920 (1995)
  48. Hu Shu-Hong, Parker Michael W., Yi Lei Jun, Wilce Matthew C. J., Benian Guy M., Kemp Bruce E., Insights into autoregulation from the crystal structure of twitchin kinase, 10.1038/369581a0
  49. Häussermann Sabine, Kittstein Walter, Rincke Gabriele, Johannes Franz-Josef, Marks Friedrich, Gschwendt Michael, Proteolytic cleavage of protein kinase Cμ upon induction of apoptosis in U937 cells : Identification of the cleavage site and characterization of the fragment, 10.1016/s0014-5793(99)01577-x
  50. Nishikawa Kiyotaka, Toker Alex, Wong Karen, Marignani Paola A., Johannes Franz-Josef, Cantley Lewis C., Association of Protein Kinase Cμ with Type II Phosphatidylinositol 4-Kinase and Type I Phosphatidylinositol-4-phosphate 5-Kinase, 10.1074/jbc.273.36.23126
  51. Johannes Franz-Josef, Hausser Angelika, Storz Peter, Truckenmüller Lars, Link Gisela, Kawakami Toshiaki, Pfizenmaier Klaus, Bruton's tyrosine kinase (Btk) associates with protein kinase C μ, 10.1016/s0014-5793(99)01424-6
  52. Iglesias Teresa, Rozengurt Enrique, Protein kinase D activation by deletion of its cysteine-rich motifs, 10.1016/s0014-5793(99)00772-3
  53. Johnson Louise N, Lowe Edward D, Noble Martin E.M, Owen David J, The structural basis for substrate recognition and control by protein kinases1, 10.1016/s0014-5793(98)00606-1
  54. Johnson Louise N, Noble Martin E.M, Owen David J, Active and Inactive Protein Kinases: Structural Basis for Regulation, 10.1016/s0092-8674(00)81092-2
  55. Edwards Amelia S., Faux Maree C., Scott John D., Newton Alexandra C., Carboxyl-terminal Phosphorylation Regulates the Function and Subcellular Localization of Protein Kinase C βII, 10.1074/jbc.274.10.6461