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Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase.

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Van Schaftingen, Emile [UCL] Hue, Louis [UCL] Hers, H G

The low-molecular-weight stimulator of phosphofructokinase [Van Schaftingen, Hue & Hers (1980) Biochem. J. 192, 887-895] has been purified from rat liver. It was completely destroyed upon incubation with 0.01 M-HCl for 10 min at 20 degrees C and fructose 6-phosphate and a reducing power equivalent in amount to the acid-labile organic phosphate were formed. It was therefore tentatively identified as fructose 2,6-bisphosphate.

Document type Article de périodique (Journal article) – In Vitro, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
Access type Accès libre
Publication date 1980
Journal information "The Biochemical journal" - Vol. 192, no. 3, p. 897-901 (1980)
Peer reviewed yes
issn 0264-6021
Publication status Publié
Affiliation UCL
MESH Subject Animals ; Chemical Phenomena ; Chemistry ; Chromatography, Ion Exchange ; Fructosediphosphates - isolation & purification - pharmacology ; Glucagon - pharmacology ; Glucose - pharmacology ; Hexosediphosphates - isolation & purification ; Liver - analysis - drug effects - enzymology ; Male ; Phosphofructokinase-1 - metabolism ; Rats ; Stimulation, Chemical
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Bibliographic reference Van Schaftingen, Emile ; Hue, Louis ; Hers, H G. Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase.. In: The Biochemical journal, Vol. 192, no. 3, p. 897-901 (1980)
Permanent URL http://hdl.handle.net/2078.1/25966