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Activation of rat heart phosphofructokinase-2 by insulin in vivo.

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Rider, Mark H. [UCL] Hue, Louis [UCL]

Fifteen minutes after the intravenous injection of overnight starved, anaesthetized rats with insulin, the concentration of fructose 2,6-biphosphate was increased more than 2-fold in the hearts of these animals. Insulin injection also caused a 2-3 fold increase in the Vmax of phosphofructokinase-2 with no detectable change in Km values. The effect persisted after precipitation of the enzyme with polyethylene glycol or after gel filtration through Sephadex G-25.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 1984
Journal information "FEBS letters" - Vol. 176, no. 2, p. 484-8 (1984)
Peer reviewed yes
issn 0014-5793
Publication status Publié
Affiliation UCL - MD/BICL - Département de biochimie et de biologie cellulaire
MESH Subject Animals ; Enzyme Activation ; Fructosediphosphates - metabolism ; Heart - drug effects ; Insulin - pharmacology ; Isoenzymes - metabolism ; Kinetics ; Male ; Myocardium - enzymology ; Phosphofructokinase-1 - metabolism ; Polyethylene Glycols - pharmacology ; Rats ; Rats, Inbred Strains
Links
  1. Hers H G, Hue L, Gluconeogenesis and Related Aspects of Glycolysis, 10.1146/annurev.bi.52.070183.003153
  2. Hue, Biochem. J. (1984)
  3. Hue, J. Biol. Chem., 257, 4308 (1982)
  4. Sochor Milena, Gonzalez Ana-Maria, McLean Patricia, Regulation of alternative pathways of glucose metabolism in rat heart in alloxan diabetes: Changes in the pentose phosphate pathway, 10.1016/0006-291x(84)91074-x
  5. Wollenberger Albert, Ristau Otto, Schoffa Georg, Eine einfache Technik der extrem schnellen Abk�hlung gr��erer Gewebest�cke, 10.1007/bf00362995
  6. Minatogawa Y, Hue L, Fructose 2,6-bisphosphate in rat skeletal muscle during contraction, 10.1042/bj2230073
  7. SCHAFTINGEN Emile, LEDERER Beatrice, BARTRONS Ramon, HERS Henri-Gery, A Kinetic Study of Pyrophosphate: Fructose-6-Phosphate Phosphotransferase from Potato Tubers. Application to a Microassay of Fructose 2,6-Bisphosphate, 10.1111/j.1432-1033.1982.tb07039.x
  8. Saggerson E. David, Lipogenesis in rat and guinea-pig isolated epididymal fat-cells, 10.1042/bj1400211
  9. Barlow, Biodata Handling with Microcomputers, 116 (1983)
  10. CLARK MICHAEL G., PATTEN GLEN S., Adrenergic Control of Phosphofructokinase and Glycolysis in Rat Heart, Current Topics in Cellular Regulation (1984) ISBN:9780121528232 p.127-176, 10.1016/b978-0-12-152823-2.50008-8
  11. Morgan, J. Biol. Chem., 236, 253 (1961)
Bibliographic reference Rider, Mark H. ; Hue, Louis. Activation of rat heart phosphofructokinase-2 by insulin in vivo.. In: FEBS letters, Vol. 176, no. 2, p. 484-8 (1984)
Permanent URL http://hdl.handle.net/2078.1/25947