Pulmonary tumor thrombotic microangiopathy in a patient with a metastatic urothelial carcinoma.

Pinto Pereira, Joao [UCL] Lelotte, Julie [UCL] Ghaye, Benoît [UCL] Laterre, Pierre-François [UCL] Hantson, Philippe [UCL]

A 78-year-old woman was admitted for acute dyspnoea. One year before, she had been treated with cisplatin and gemcitabine for a high grade urothelial carcinoma. Immunotherapy was discussed 9 months later due the progression of bone metastases but could not be administered before this episode of respiratory distress. There was a major discrepancy between the findings of a limited pulmonary embolism at thoracic tomodensitometry and the severity of a recently developed pulmonary hypertension at echocardiography. The patient presented cardiac arrest on day 6 and post-mortem findings were consistent with diffuse pulmonary tumor thrombotic microangiopathy, a rare complication of urothelial carcinoma.