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First epileptic seizure induced by occupational nickel poisoning.

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Denays, Roger Kumba, Claudine Lison, Dominique [UCL] De Bels, David

Toxic causes of seizures are numerous: alcohol and other substances of abuse, drugs, and industrial and household products. However, in the absence of a clearly suggestive history and/or associated symptoms and signs, identification of the toxic origin of new-onset seizures may be extremely difficult. We report here the case of a patient admitted in our hospital after a single generalized tonic-clonic seizure. The remarkable coincidence that a colleague of his, with whom he was working to clean the same workshop, had been admitted 1 week earlier for respiratory distress, coma, and de novo nonconvulsive focal status epilepticus, led us to consider a possible toxicologic etiology. Urine analysis revealed a high nickel concentration, suggestive of acute nickel poisoning.

Document type Article de périodique (Journal article) – Case Reports, Journal Article
Access type Accès libre
Publication date 2005
Journal information "Epilepsia" - Vol. 46, no. 6, p. 961-2 (2005)
Peer reviewed yes
issn 0013-9580
Publication status Publié
Affiliations UCL - MD/ESP - Ecole de santé publique
UCL - (SLuc) Service de biochimie médicale
MESH Subject Acute Disease ; Adult ; Epilepsy - chemically induced - urine ; Humans ; Male ; Nickel - poisoning ; Occupational Diseases - chemically induced - diagnosis - urine ; Occupational Exposure - adverse effects ; Poisoning - diagnosis - urine
Links
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Bibliographic reference Denays, Roger ; Kumba, Claudine ; Lison, Dominique ; De Bels, David. First epileptic seizure induced by occupational nickel poisoning.. In: Epilepsia, Vol. 46, no. 6, p. 961-2 (2005)
Permanent URL http://hdl.handle.net/2078.1/25864