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ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin

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Andrade, Nuno Komnenovic, Vukoslav Blake, Sophia M. Jossin, Yves [UCL] Howell, Brian Goffinet, André [UCL] Nimpf, Johannes

Postnatal migration of interneuron precursors from the subventricular zone to the olfactory bulb occurs in chains that form the substrate for the rostral migratory stream. Reelin is suggested to induce detachment of neuroblasts from the chains when they arrive at the olfactory bulb. Here we show that ApoER2 and possibly very-low-density lipoprotein receptor (VLDLR) and their intracellular adapter protein Dab1 are involved in chain formation most likely independent of Reelin. F-spondin, which is present in the stream, may act as ligand for ApoER2 and VLDLR. In mice lacking either both receptors or Dab1 chain formation is severely compromised, and as a consequence the rostral migratory stream is virtually absent and neuroblasts accumulate in the subventricular zone. The mutant animals exhibit severe neuroanatomical defects in the subventricular zone and in the olfactory bulb. These data demonstrate a cell-autonomous function of ApoER2, and most likely VLDLR and Dab1, in postnatal migration of neuroblasts in the forebrain, which is suggested to depend on ligands other than Reelin.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2007
Journal information "Proceedings of the National academy of sciences of the United States of America" - Vol. 104, no. 20, p. 8508-8513 (2007)
Peer reviewed yes
Publisher National academy of sciences
issn 0027-8424
e-issn 1091-6490
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Animals ; Animals, Newborn ; Brain - cytology ; Cell Adhesion Molecules, Neuronal - deficiency - metabolism ; Cell Movement ; Extracellular Matrix Proteins - deficiency - metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Nerve Tissue Proteins - deficiency - metabolism ; Neurons - cytology ; Olfactory Bulb - cytology ; Receptors, LDL - metabolism ; Receptors, Lipoprotein - deficiency - metabolism ; Serine Endopeptidases - deficiency - metabolism
Keywords Reelin signaling ; Postnatal neurogenesis ; Tangential neuronal migration
Links
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Bibliographic reference Andrade, Nuno ; Komnenovic, Vukoslav ; Blake, Sophia M. ; Jossin, Yves ; Howell, Brian ; et. al. ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin. In: Proceedings of the National academy of sciences of the United States of America, Vol. 104, no. 20, p. 8508-8513 (2007)
Permanent URL http://hdl.handle.net/2078.1/25777