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Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors.

Bibliographic reference Azzi, Mounia ; Charest, Pascale G ; Angers, Stéphane ; Rousseau, Guy ; Kohout, Trudy ; et. al. Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors.. In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, no. 20, p. 11406-11 (2003)
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  1. Science Signaling, 40, RE1 (2000)
  2. Schmitt John M., Stork Philip J. S., β2-Adrenergic Receptor Activates Extracellular Signal-regulated Kinases (ERKs) via the Small G Protein Rap1 and the Serine/Threonine Kinase B-Raf, 10.1074/jbc.m003213200
  3. Luttrell L. M., Ferguson S. S. G., Daaka Y., Miller W. E., Maudsley S., Della Rocca G. J., Lin F.-T., Kawakatsu H., Owada K., Luttrell D. K., Caron M. G., Lefkowitz R. J., β-Arrestin-Dependent Formation of β2Adrenergic Receptor-Src Protein Kinase Complexes, 10.1126/science.283.5402.655
  4. DeFea K.A., Zalevsky J., Thoma M.S., Déry O., Mullins R.D., Bunnett N.W., β-Arrestin–Dependent Endocytosis of Proteinase-Activated Receptor 2 Is Required for Intracellular Targeting of Activated Erk1/2, 10.1083/jcb.148.6.1267
  5. McDonald P. H., beta -Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3, 10.1126/science.290.5496.1574
  6. Luttrell L. M., Roudabush F. L., Choy E. W., Miller W. E., Field M. E., Pierce K. L., Lefkowitz R. J., Activation and targeting of extracellular signal-regulated kinases by  -arrestin scaffolds, 10.1073/pnas.041604898
  7. KENAKIN T., Inverse, protean, and ligand-selective agonism: matters of receptor conformation, 10.1096/fj.00-0438rev
  8. Adam Lynda, Bouvier Michel, Jones Teresa L. Z., Nitric Oxide Modulates β2-Adrenergic Receptor Palmitoylation and Signaling, 10.1074/jbc.274.37.26337
  9. Mercier Jean-François, Salahpour Ali, Angers Stéphane, Breit Andreas, Bouvier Michel, Quantitative Assessment of β1- and β2-Adrenergic Receptor Homo- and Heterodimerization by Bioluminescence Resonance Energy Transfer, 10.1074/jbc.m205767200
  10. Angers S., Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET), 10.1073/pnas.060590697
  11. American Journal of Physiology -- Legacy Content, 80, R355 (2001)
  12. LAEMMLI U. K., Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4, 10.1038/227680a0
  13. Blaukat Andree, Pizard Anne, Rajerison Rabary M., Alhenc-Gelas François, Müller-Esterl Werner, Dikic Ivan, Activation of mitogen-activated protein kinase by the bradykinin B2receptor is independent of receptor phosphorylation and phosphorylation-triggered internalization, 10.1016/s0014-5793(99)00613-4
  14. Chidiac, Molecular Pharmacology, 45, 490 (1994)
  15. Lefkowitz Robert J., Daaka Yehia, Luttrell Louis M., 10.1038/36362
  16. MURRAY DAVID R., DUGAN JENNIFER, Overview of Recent Clinical Trials in Heart Failure: What Is the Current Standard of Care? : , 10.1097/00045415-200008060-00007
  17. Wan Yong, Huang Xin-Yun, Analysis of the Gs/Mitogen-activated Protein Kinase Pathway in Mutant S49 Cells, 10.1074/jbc.273.23.14533
  18. Zamah A. Musa, Delahunty Martha, Luttrell Louis M., Lefkowitz Robert J., Protein Kinase A-mediated Phosphorylation of the β2-Adrenergic Receptor Regulates Its Coupling to Gsand Gi : DEMONSTRATION IN A RECONSTITUTED SYSTEM, 10.1074/jbc.m202753200
  19. SALOMON, Molecular Pharmacology, 19, 109 (1981)
  20. Luttrell Louis M., van Biesen Tim, Hawes Brian E., Koch Walter J., Touhara Kazushige, Lefkowitz Robert J., GβγSubunits Mediate Mitogen-activated Protein Kinase Activation by the Tyrosine Kinase Insulin-like Growth Factor 1 Receptor, 10.1074/jbc.270.28.16495
  21. Seta Koichi, Nanamori Masakatsu, Modrall J. Gregory, Neubig Richard R., Sadoshima Junichi, AT1 Receptor Mutant Lacking Heterotrimeric G Protein Coupling Activates the Src-Ras-ERK Pathway without Nuclear Translocation of ERKs, 10.1074/jbc.m109221200
  22. Maudsley Stuart, Pierce Kristen L., Zamah A. Musa, Miller William E., Ahn Seungkirl, Daaka Yehia, Lefkowitz Robert J., Luttrell Louis M., The β2-Adrenergic Receptor Mediates Extracellular Signal-regulated Kinase Activation via Assembly of a Multi-receptor Complex with the Epidermal Growth Factor Receptor, 10.1074/jbc.275.13.9572
  23. DeFea K. A., Vaughn Z. D., O'Bryan E. M., Nishijima D., Dery O., Bunnett N. W., The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex, 10.1073/pnas.190276697
  24. Pierce K. L., Maudsley S., Daaka Y., Luttrell L. M., Lefkowitz R. J., Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors, 10.1073/pnas.97.4.1489
  25. Kohout T. A., beta -Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking, 10.1073/pnas.041608198
  26. Pierce Kristen L., Lefkowitz Robert J., Classical and new roles of β-arrestins in the regulation of G-PROTEIN-COUPLED receptors, 10.1038/35094577
  27. Benovic Jeffrey L., Bouvier Michel, Caron Marc G., Lefkowitz Robert J., Regulation of Adenylyl Cyclase-Coupled beta-Adrenergic Receptors, 10.1146/annurev.cb.04.110188.002201
  28. Scott Mark G. H., Benmerah Alexandre, Muntaner Olivier, Marullo Stefano, Recruitment of Activated G Protein-coupled Receptors to Pre-existing Clathrin-coated Pits in Living Cells, 10.1074/jbc.m106586200
  29. Zhang Jie, Ferguson Stephen S. G., Barak Larry S., Ménard Luc, Caron Marc G., Dynamin and β-Arrestin Reveal Distinct Mechanisms for G Protein-coupled Receptor Internalization, 10.1074/jbc.271.31.18302
  30. Goodman Oscar B., Krupnick Jason G., Santini Francesca, Gurevich Vsevolod V., Penn Raymond B., Gagnon Alison W., Keen James H., Benovic Jeffrey L., β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor, 10.1038/383447a0
  31. Oakley Robert H., Laporte Stéphane A., Holt Jason A., Barak Larry S., Caron Marc G., , Association of β-Arrestin with G Protein-coupled Receptors during Clathrin-mediated Endocytosis Dictates the Profile of Receptor Resensitization, 10.1074/jbc.274.45.32248
  32. Ghanouni Pejman, Gryczynski Zygmunt, Steenhuis Jacqueline J., Lee Tae Weon, Farrens David L., Lakowicz Joseph R., Kobilka Brian K., Functionally Different Agonists Induce Distinct Conformations in the G Protein Coupling Domain of the β2Adrenergic Receptor, 10.1074/jbc.c100162200
  33. Berg, Molecular Pharmacology, 54, 94 (1998)
  34. Zhang J., Ferguson S. S. G., Barak L. S., Bodduluri S. R., Laporte S. A., Law P.-Y., Caron M. G., Role for G protein-coupled receptor kinase in agonist-specific regulation of  -opioid receptor responsiveness, 10.1073/pnas.95.12.7157
  35. Whistler J. L., von Zastrow M., Morphine-activated opioid receptors elude desensitization by  -arrestin, 10.1073/pnas.95.17.9914
  36. J MOL PHARMACOL, 51, 357 (1997)
  37. Bhowmick N., The Endothelin Subtype A Receptor Undergoes Agonist- and Antagonist-Mediated Internalization in the Absence of Signaling, 10.1210/en.139.7.3185
  38. Gurevich Vsevolod V., Pals-Rylaarsdam Robin, Benovic Jeffrey L., Hosey M. Marlene, Onorato James J., Agonist-Receptor-Arrestin, an Alternative Ternary Complex with High Agonist Affinity, 10.1074/jbc.272.46.28849
  39. Martini L., NK1 Receptor Fused to beta -Arrestin Displays a Single-Component, High-Affinity Molecular Phenotype, 10.1124/mol.62.1.30
  40. Molecular Pharmacology, 58, 1230 (2000)