A novel synthetic strategy toward N-acyl sulfamates was developed. Interestingly, fluorosulfates, a new emerging class of electrophiles, were used to construct the sulfamate core. This precludes handling of chlorosulfonyl isocyanate and sulfamoyl chloride. In combination with amides, a wide and diverse set of N-acyl sulfamates was synthesized, including functionalized bioactive compounds. Furthermore, initial results showed that this method is also amenable to access N-thioacyl sulfamates.
Gilles, Philippe ; Vangrunderbeeck, Sarah ; et. al. Synthesis of N-Acyl Sulfamates from Fluorosulfates and Amides. In: Synthesis of N-Acyl Sulfamates from Fluorosulfates and Amides, Vol. 84, no.2, p. 8 (2018)
