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Muconic acid in urine: a reliable indicator of occupational exposure to benzene

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Lauwerys, Robert [UCL] Buchet, Jean-Pierre [UCL] Andrien, Fabian

In male subjects not occupationally exposed to benzene, the concentration of muconic acid (MA) in urine is usually below 0.5 mg/g creatinine. At ambient levels of benzene exposure (below 0.01 ppm), the mean MA level was greater in 21 smokers than in 14 nonsmokers. In 38 male subjects employed in garages and coke ovens, a statistically significant correlation was found between the airborne concentration of benzene measured with passive monitors and MA in postshift urine. The mean postshift MA concentrations corresponding to a benzene 8-hour time-weighted average exposure (TWA) of 0.5 and 1 ppm were 0.8 and 1.4 mg/g creatinine, respectively.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1994
Journal information "American Journal of Industrial Medicine" - Vol. 25, no. 2, p. 297-300 (1994)
Peer reviewed yes
Publisher JohnWiley & Sons, Inc. (Hoboken)
issn 0271-3586
e-issn 1097-0274
Publication status Publié
Affiliations UCL - MD/ESP - Ecole de santé publique
UCL - (SLuc) Service d'anatomie pathologique
UCL - (SLuc) Centre de toxicologie clinique
MESH Subject Adult ; Air Pollutants, Occupational - analysis - metabolism ; Benzene - analysis - metabolism ; Biological Markers - urine ; Humans ; Male ; Occupational Exposure - analysis ; Smoking - urine ; Sorbic Acid - analogs & derivatives - analysis - metabolism ; Urine - chemistry
Keywords Benzene exposure ; Biological monitoring ; Smoking exposures ; Biological markers
Links
  1. Bechtold W.E., Lucier G., Birnbaum L.S., Yin S.N., Li G.L., Henderson R.F., MUCONIC ACID DETERMINATIONS IN URINE AS A BIOLOGICAL EXPOSURE INDEX FOR WORKERS OCCUPATIONALLY EXPOSED TO BENZENE, 10.1080/15298669191365072
  2. Ducos, Int Arch Occup Environ Health, 62, 529 (1990)
  3. Ducos, Int Arch Occup Environ Health, 64, 309 (1992)
  4. Johnson, Am J Ind Med, 21, 749 (1992)
Bibliographic reference Lauwerys, Robert ; Buchet, Jean-Pierre ; Andrien, Fabian. Muconic acid in urine: a reliable indicator of occupational exposure to benzene. In: American Journal of Industrial Medicine, Vol. 25, no. 2, p. 297-300 (1994)
Permanent URL http://hdl.handle.net/2078.1/24582