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The mutagenicity of nitrite in the Salmonella/microsome test system.

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Balimandawa, M. De Meester, Conrad [UCL] Léonard, Albert [UCL]

The bacterial strains of Salmonella typhimurium used for detection of base-pair substitutions (TA1530, TA1535, TA100 and TA102) and various types of frameshift mutations (YG1024, DJ400 and DJ460) were exposed to nitrites in the Salmonella/microsome test system. In agreement with published data, nitrites exhibited mutagenic activity in standard strains TA1530, TA1535 and TA100. The TA102 strain was insensitive as were the frameshift tester strains despite their genetically manipulated genome increasing their sensitivity.

Document type Article de périodique (Journal article) – Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
Publication date 1994
Journal information "Mutation research" - Vol. 321, no. 1-2, p. 7-11 (1994)
issn 0027-5107
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Biotransformation ; Frameshift Mutation ; Microsomes, Liver - enzymology ; Mutagenicity Tests ; Point Mutation ; Regression Analysis ; Salmonella typhimurium - drug effects - genetics ; Sodium Nitrite - toxicity ; Species Specificity
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Bibliographic reference Balimandawa, M. ; De Meester, Conrad ; Léonard, Albert. The mutagenicity of nitrite in the Salmonella/microsome test system.. In: Mutation research, Vol. 321, no. 1-2, p. 7-11 (1994)
Permanent URL http://hdl.handle.net/2078.1/24576