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B lymphocyte and macrophage expression of carcinoembryonic antigen-related adhesion molecules that serve as receptors for murine coronavirus

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Coutelier, Jean-Paul [UCL] Godfraind, Catherine [UCL] Dveksler, Gabriela S. Wysocka, Maria Cardellichio, Christine B. Noël, Henri [UCL] Holmes, Katheryn V.

The expression of carcinoembryonic antigen (CEA)-related glycoproteins that have been associated with intercellular adhesion and that serve as receptors for mouse hepatitis virus (MHV) was analyzed in cells from the immune system of BALB/c mice using immunolabeling and RNA polymerase chain reaction amplification of receptor transcripts. These glycoproteins, which are called biliary glycoproteins, were highly expressed in B lymphocytes, including cells of the B-1a (CD5+) lineage, and in macrophages, but were not detectable in resting T lymphocytes. Similarly, murine cell lines of B cell and macrophage origin expressed messenger RNA encoding CEA-related molecules, while the corresponding mRNA was only slightly detectable in a T cell line. These CEA-related cell adhesion glycoproteins were also expressed in endothelial cells. Therefore, their specific interaction with their so far unknown ligand may be of functional importance in cellular interactions in the immune response. Monoclonal antibody directed against these glycoproteins blocked MHV-A59 infection of the B cell-derived SP20 cell line. Thus, the functional receptors for MHV on B lymphocytes, like those on murine fibroblasts, are isoforms of CEA-related glycoproteins. Treatment of B cells with anti-receptor antibody also blocked B cell-mediated cytotoxicity against MHV-A59-infected fibroblasts, indicating that this phenomenon is mediated by interaction of viral attachment protein on the infected target cells with specific CEA-related receptor glycoproteins on the effector B cells.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1994
Journal information "European Journal of Immunology" - Vol. 24, no. 6, p. 1383-1390 (1994)
Peer reviewed yes
Publisher Wiley - V C H Verlag GmbH & Co. KGaA (Weinheim)
issn 0014-2980
e-issn 1521-4141
Publication status Publié
Affiliations UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
UCL - MD/MNOP - Département de morphologie normale et pathologique
UCL - (SLuc) Service d'anatomie pathologique
UCL - (SLuc) Centre de malformations vasculaires congénitales
MESH Subject Animals ; Antibodies, Viral - immunology ; B-Lymphocytes - immunology ; Base Sequence ; Cell Adhesion Molecules - biosynthesis ; Cell Line ; Cytotoxicity, Immunologic ; Female ; Macrophages - immunology ; Mice ; Mice, Inbred BALB C ; Molecular Sequence Data ; Murine hepatitis virus - immunology ; Polymerase Chain Reaction ; Receptors, Virus - biosynthesis
Keywords Mouse hepatitis virus receptor ; Adhesion molecule ; B lymphocyte ; Carcinoembryonic antigen
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Bibliographic reference Coutelier, Jean-Paul ; Godfraind, Catherine ; Dveksler, Gabriela S. ; Wysocka, Maria ; Cardellichio, Christine B. ; et. al. B lymphocyte and macrophage expression of carcinoembryonic antigen-related adhesion molecules that serve as receptors for murine coronavirus. In: European Journal of Immunology, Vol. 24, no. 6, p. 1383-1390 (1994)
Permanent URL http://hdl.handle.net/2078.1/24494