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Microstructural alterations in the white matter of children with dyslexia assessed by multi-fascicle diffusion compartment imaging

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Delinte, Nicolas [UCL] Gosse, Claire [UCL] Dricot, Laurence [UCL] Dessain, Quentin [UCL] Simon, Mathieu [UCL] Macq, Benoît [UCL] Van Reybroeck, Marie [UCL] Rensonnet, Gaëtan [UCL]

Dyslexia is a deviant development of both reading and spelling abilities aecting 5-12 % of children, yet the microstructural changes it induces in the white matter (WM) remain incompletely understood. This study analyzed multi-shell diusion MRI on a population of 17 dyslexic children and 18 controls. Advanced models (Diamond & Microstructure Fingerprinting), able to separately characterize intersecting fascicles within a voxel, obtained stronger correlations with children's reading and spelling performances than traditional DTI and showed increased sensitivity. The novel indices, obtained from these models, suggested rened interpretations of the microstructural characteristics of dyslexia in WM pathways.

Document type Communication à un colloque (Conference Paper) – Poster
Access type Accès libre
Publication date 2021
Language Anglais
Conference "29th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM)" (du 15/05/2021 au 20/05/2021)
Journal information "Proc. Intl. Soc. Mag. Reson. Med." - Vol. 29 (2021)
issn 1545-4428
Affiliation UCL - SST/ICTM/ELEN - Pôle en ingénierie électrique
Keywords diffusion ; microstructure ; brain ; MRI
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Bibliographic reference Delinte, Nicolas ; Gosse, Claire ; Dricot, Laurence ; Dessain, Quentin ; Simon, Mathieu ; et. al. Microstructural alterations in the white matter of children with dyslexia assessed by multi-fascicle diffusion compartment imaging.29th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM) (du 15/05/2021 au 20/05/2021). In: Proc. Intl. Soc. Mag. Reson. Med., Vol. 29 (2021)
Permanent URL http://hdl.handle.net/2078.1/244512