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Ferumoxides and Tc-99m sulfur colloid: comparison of the tumor-to-liver uptake in focal nodular hyperplasia

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Grandin, Cécile [UCL] Van Beers, Bernard [UCL] Pauwels, Stanislas [UCL] Demeure, Roger [UCL] Jamart, Jacques [UCL] Pringot, Jacques [UCL]

The tumor-to-liver uptake of two reticuloendothelial agents, namely ferumoxides and technetium-99m (Tc-99m) sulfur colloid, was compared in focal nodular hyperplasia (FNH). Twelve patients with FNH who had undergone ferumoxides-enhanced MR imaging and planar Tc-99m sulfur colloid scintigraphy within 1 year were included from the study. Fourteen patients with FNH with a diameter larger than 3 cm were selected for the comparison. The tumor-to-liver ferumoxides uptake was calculated and the Tc-99m sulfur colloid uptake was assessed visually. Fermuoxides uptake was observed in all but one patient with FNH (mean tumor-to-liver ratio = .36). The six tumors showing normal (n = 5) or increased (n = 1) radiocolloid uptake when compared to the liver accumulated more ferumoxides than the eight tumors showing decreased radiocolloid uptake (P < .01). However, in some tumors, no direct relation was observed between ferumoxides and Tc-99m sulfur colloid uptake. Our observations suggest that ferumoxides uptake might not exactly mimic Tc-99m sulfur colloid uptake in FNH.

Document type Article de périodique (Journal article) – Article de recherche – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 1997
Language Anglais
Journal information "Journal of Magnetic Resonance Imaging" - Vol. 7, no. 1, p. 125-129 (1997)
Peer reviewed yes
Publisher JohnWiley & Sons, Inc. (Hoboken)
issn 1053-1807
e-issn 1522-2586
Publication status Publié
Affiliations UCL - MD/RAIM - Département de radiologie et d'imagerie médicale
UCL - (SLuc) Service de radiologie
UCL - (SLuc) Centre de référence pour l'épilepsie réfractaire
UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service de médecine nucléaire
UCL - (MGD) Unité de support scientifique
MESH Subject Adult ; Contrast Media - pharmacokinetics ; Diagnosis, Differential ; Female ; Humans ; Hyperplasia - diagnosis ; Image Enhancement - methods ; Iron - diagnostic use - pharmacokinetics ; Liver - metabolism ; Liver Diseases - diagnosis - metabolism ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Oxides - diagnostic use - pharmacokinetics ; Sensitivity and Specificity ; Technetium - diagnostic use - pharmacokinetics
Keywords Magnetic resonance (MR) ; Contrast enhancement ; Neoplasms ; Liver ; Focal nodular hyperplasia ; Iron ; Diagnostic use ; Technetium-99m sulfur colloid ; Radionuclide study
Links
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Bibliographic reference Grandin, Cécile ; Van Beers, Bernard ; Pauwels, Stanislas ; Demeure, Roger ; Jamart, Jacques ; et. al. Ferumoxides and Tc-99m sulfur colloid: comparison of the tumor-to-liver uptake in focal nodular hyperplasia. In: Journal of Magnetic Resonance Imaging, Vol. 7, no. 1, p. 125-129 (1997)
Permanent URL http://hdl.handle.net/2078.1/24304