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Thrombopoietin. A review.

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Baatout, S.

The regulator of platelet count is believed to be thrombopoietin (mpl ligand). It is thought to act on the megakaryocytic lineage affecting the proliferation of committed cells, the maturation of megakaryocytes and the blood platelet levels by activation of its receptor (the c-mpl). Recently, it has been purified and sequenced. Thrombopoietin offers potential applications for treatment of thrombocytopenia.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't, Review
Publication date 1997
Journal information "Haemostasis" - Vol. 27, no. 1, p. 1-8 (1997)
issn 0301-0147
Publication status Publié
Affiliation UCL
MESH Subject Animals ; Gene Expression Regulation ; Humans ; Megakaryocytes - metabolism - physiology ; Neoplasm Proteins ; Platelet Count ; Proto-Oncogene Proteins - genetics - metabolism ; Receptors, Cytokine ; Receptors, Thrombopoietin ; Thrombopoietin - drug effects - genetics - metabolism - physiology
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Bibliographic reference Baatout, S.. Thrombopoietin. A review.. In: Haemostasis, Vol. 27, no. 1, p. 1-8 (1997)
Permanent URL http://hdl.handle.net/2078.1/24301