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Interleukin 9 and its receptor: an overview of structure and function.

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Demoulin, Jean-Baptiste [UCL] Renauld, Jean-Christophe [UCL]

Interleukin-9 (IL-9) is a multifunctional cytokine produced by activated TH2 clones in vitro and during TH2-like T cell responses in vivo. Although IL-9 was initially described as a T cell growth factor, its role in T cell responses is still unclear. While freshly isolated normal T cells do not respond to IL-9, this cytokine induces the proliferation of murine T cell lymphomas in vitro, and in vivo overexpression of IL-9 results in the development of thymic lymphomas. In the human, the existence of an IL-9 mediated autocrine loop has been suggested for some malignancies such as Hodgkin's disease. Various observations indicate that IL-9 is actively involved in mast cells responses by inducing the proliferation and differentiation of these cells. Other potential biological targets for IL-9 include B lymphocytes, and hematopoietic progenitors, for which higher responses were observed with foetal or transformed cells as compared to normal adult progenitors. The IL-9 receptor is a member of the hemopoietin receptor superfamily and interacts with the gamma chain of the IL-2 receptor for signaling. Signal transduction studies have stressed the role of the Jak-STAT pathway in various IL-9 bioactivities, whereas the 4PS/IRS2 adaptor protein might also play a significant role in IL-9 signaling.

Document type Article de périodique (Journal article) – Journal Article, Review
Publication date 1998
Journal information "International reviews of immunology" - Vol. 16, no. 3-4, p. 345-64 (1998)
Peer reviewed yes
issn 0883-0185
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Animals ; Humans ; Interleukin-9 - chemistry - physiology ; Mice ; Molecular Structure ; Receptors, Interleukin - chemistry - physiology ; Receptors, Interleukin-9
Links
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Bibliographic reference Demoulin, Jean-Baptiste ; Renauld, Jean-Christophe. Interleukin 9 and its receptor: an overview of structure and function.. In: International reviews of immunology, Vol. 16, no. 3-4, p. 345-64 (1998)
Permanent URL http://hdl.handle.net/2078.1/24223