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Fatal Idiopathic Hyperammonemia after Induction Chemotherapy for Acute Myeloid Leukemia.

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Angelo, Christophe [UCL] Vincent, Marie-Françoise [UCL] Komuta, Mina [UCL] Hantson, Philippe [UCL] Straetmans, Nicole [UCL] Boulet, Edwige [UCL]

Idiopathic hyperammonemia is a rare but potentially fatal complication occurring in patients with acute leukemia or bone marrow transplantation. The role of some specific anticancer drugs may be discussed, but the etiology of hyperammonemia is often multifactorial. We report the case of a 40-year-old woman who developed fatal idiopathic hyperammonemia two weeks after induction chemotherapy with idarubicin-aracytine for acute myeloid leukemia. Despite intensive care management and extrarenal epuration, the patient was declared brain dead two days after hyperammonemia onset.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2020
Language Anglais
Journal information "Case reports in hematology" - Vol. 2020, p. 3136074 [1-4] (2020)
Peer reviewed yes
Publisher Hindawi Pub. Corp. ((United States) New York, NY)
issn 2090-6560
e-issn 2090-6560
Publication status Publié
Affiliations UCL - SSS/DDUV - Institut de Duve
UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie
UCL - SSS/IREC/MEDA - Pôle de médecine aiguë
UCL - SSS/IREC/SLUC - Pôle St.-Luc
UCL - (SLuc) Service de soins intensifs
UCL - (SLuc) Service de biochimie médicale
UCL - (SLuc) Service d'anatomie pathologique
UCL - (SLuc) Service d'hématologie
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Bibliographic reference Angelo, Christophe ; Vincent, Marie-Françoise ; Komuta, Mina ; Hantson, Philippe ; Straetmans, Nicole ; et. al. Fatal Idiopathic Hyperammonemia after Induction Chemotherapy for Acute Myeloid Leukemia.. In: Case reports in hematology, Vol. 2020, p. 3136074 [1-4] (2020)
Permanent URL http://hdl.handle.net/2078.1/241904